Abstract: A scalable method for producing DNA/polycation particles having an optimal, defined particle size with multiple virus assembly plasmids for efficient transfection of viral production cells in suspension cultures. The presently disclosed DNA/polycation particles yield superior and reproducible transfection activity and shelf stability in the suspension form and can be used as an off-the-shelf product. The presently disclosed DNA/polycation particle formulation can potentially simplify and streamline the viral manufacturing process and improve production quality and consistency.

Abstract: Methods for preparing nucleic acid/lipid particles of an optimum particle size for efficient transfection of cells in vitro and in vivo local transfection are provided. The method is based on kinetic control of the nucleic acid/lipid nanoparticle assembly to prepare shelf-stable particles with defined sizes between about 50 nm and 1200 nm. The size-dependent characteristics of the nucleic acid/lipid particle-mediated transfection for the size range between 50 nm and 1200 nm also is provided.

Abstract: Disclosed in the present application are a concrete protection material, and a preparation method and a construction method therefor. The concrete protection material consists of 50%-90% of a component A and 10%-50% of a component B in percentage by weight, where the component A is prepared from 30%-65% of organic silicon, 2%-5% of nano-silicon dioxide and the balance of an organic solvent in percentage by weight; and the component B is prepared from 20%-50% of an organic base and the balance of water in percentage by weight. The present application not only can form nano-particles having a strengthening effect in capillary channels of a concrete surface layer, but also can achieve a technical effect of superhydrophobicity on the concrete surface layer.

Abstract: The present invention relates to the technical field of acetonitrile refining, and in particular, to an improved acetonitrile purification process for an ultrahigh performance liquid chromatography-mass spectrometer. The present invention provides an acetonitrile purification process. A high-purity finished product may be obtained by performing operations of oxidation, rectification adsorption, drying, reflux rectification and filtration on industrial acetonitrile and controlling related parameters such as temperature, flow and the like, continuous production is ensured, a light transmittance of the finished product in ultraviolet rays of 200 to 260 nm is greater than or equal to 95%, water and impurities in the industrial acetonitrile are removed, and the requirements of the ultrahigh performance liquid chromatography-mass spectrometer are met; moreover, by controlling process parameters and equipment.

Abstract: This disclosure may provide a system and a method. The method may include obtaining one or more sets of reference signals collected by a coil of a magnetic resonance imaging (MRI) device in a pre-scan. The pre-scan may be performed on a subject before an MRI scan of the subject. The method may also include obtaining a first fault detection model. The first fault detection model may be a trained machine learning model. The method may further include determining whether the coil has a failure based on the one or more sets of reference signals and the first fault detection model.

Abstract: The embodiment of the present disclosure provides an imaging method for a dispersion energy spectrum of surface waves, an electronic device, and a storage medium. The imaging method includes: obtaining first surface wave data, and the first surface wave data corresponding to a space-time domain representation; processing the first surface wave data to obtain the second surface wave data, and the second surface wave data corresponding to a space-frequency domain representation; and processing the second surface wave data based on a preset algorithm to obtain a first imaging result, the first imaging result corresponding to a slowness-frequency domain representation.

Abstract: Disclosed are the optimal composition and size of DNA/polycation particles for efficient transfection of viral production cells in both adherent and suspension cultures. The size-dependent feature of DNA/polycation particle-mediated transfection for particles between 50 nm and 1000 nm also is disclosed. A new scalable method based on kinetic control of DNA/polycation nanoparticle assembly to prepare shelf-stable particles with defined sizes between 50 nm and 1000 nm also is disclosed. The presently disclosed DNA/polycation particles yield superior and reproducible transfection activity and shelf stability and can be used as an off-the-shelf product.

Abstract: The present invention discloses a polypeptide compound, a pharmaceutical composition, and a preparation method and use thereof. The structural formula of the polypeptide compound is shown in general formula (I): Such polypeptide compounds as ?-opioid receptor agonists have the advantages of better activity and the potential to become clinical candidate compounds.

Abstract: Satellite communication methods and payloads are described. The payload and methods are designed to enable effective use of carrier signals in the guard band region of a channelized band of spectrum. An on-board digital channelizer may implement a band edge power monitor for measuring power spectral density in the band edges of a channel and, if it exceeds a preset threshold level, downscaling the signal amplitude in the band edges to prevent hardware damage to the payload. The channelizer may further implement a band edge gain adjustment filter for shaping the overall frequency response to flatten the response across adjacent channels, including through the guard band region between the passbands of the adjacent channels.

Abstract: Satellite communication methods and payloads are described. The payload and methods are designed to enable effective use of carrier signals in the guard band region of a channelized band of spectrum. An on-board digital channelizer may implement a band edge power monitor for measuring power spectral density in the band edges of a channel and, if it exceeds a preset threshold level, downscaling the signal amplitude in the band edges to prevent hardware damage to the payload. The channelizer may further implement a band edge gain adjustment filter for shaping the overall frequency response to flatten the response across adjacent channels, including through the guard band region between the passbands of the adjacent channels.

Abstract: The present invention relates to protein markers for ER-positive-like and ER-negative-like breast cancer. Methods for differentiating ER-positive-like and ER-negative-like breast cancer in a subject having breast cancer are provided, such methods including the detection of levels of a variety of biomarkers for ER-positive-like and ER-negative-like breast cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Abstract: The application relates to an aircraft, a method, an apparatus and a computer readable storage medium for controlling the aircraft with at least one sensor arranged thereon, the method including detecting a motor state of the aircraft, acquiring at least one sensing data of the at least one sensor, and controlling the aircraft to perform a startup operation or a shutdown operation according to the motor state and the at least one sensing data, so that the aircraft can be autonomously controlled to perform the startup operation or the shutdown operation, and the user experience is improved.

Abstract: Provided are methods for cancer therapy. The method comprises inhibiting the expression and/or activity of ATF7IP and/or SETDB1 in cancer cells. Also provided is a method for identifying individuals for cancer therapy that includes using ATF7IP and/or SETDB1 inhibition.

Abstract: The present disclosure provides gene expression profiles that are associated with cancer, including certain gene expression profiles that differentiate between cancer that is at a high risk of recurrence. The gene expression profiles can be measured at the nucleic acid or protein level. The gene expression profiles can also be used to identify a subject for cancer treatment. Also provided are kits for use in predicting cancer recurrence and/or prognosing cancer and an array comprising probes for detecting the unique gene expression profiles associated with cancer.

Abstract: The present invention discloses a polypeptide compound, a pharmaceutical composition, and a preparation method and use thereof. The structural formula of the polypeptide compound is shown in general formula (I): Such polypeptide compounds as ?-opioid receptor agonists have the advantages of better activity and the potential to become clinical candidate compounds.

Abstract: A high throughput satellite (HTS) and a method of operating the HTS for relaying data between a low earth orbit (LEO) satellite and a target ground station, where the HTS provides spot beams for a spot beam coverage area. The method of operating the HTS includes: determining an estimated trajectory of an orbiting LEO satellite; assigning a plurality of assigned spot beams having a matching color re-use polarization; and transmitting assignments of the plurality of assigned spot beams to the high throughput satellite to cause the high throughput satellite to maintain the inter-satellite link via a first spot beam and one or more assigned subsequent spot beams having the matching color re-use polarization.

Abstract: A geolocation method and system for locating the source of interference to a high throughput satellite. The method involves determining relative power level differences between interference signals received by the victim spot beam and co-colored nearby spot beams on the same satellite. Using beam pattern data, the relative power levels for a pair of beams determines contour lines of possible location the correspond to the relative power difference in the signals received by the two beams in the pair. A point of intersection of contour lines from multiple pairs of spot beams indicates the location of the source of interference.

Abstract: The application relates to an aircraft, a method, an apparatus and a computer readable storage medium for controlling the aircraft with at least one sensor arranged thereon, the method including detecting a motor state of the aircraft, acquiring at least one sensing data of the at least one sensor, and controlling the aircraft to perform a startup operation or a shutdown operation according to the motor state and the at least one sensing data, so that the aircraft can be autonomously controlled to perform the startup operation or the shutdown operation, and the user experience is improved.

Abstract: A high throughput satellite (HTS) and a method of operating the HTS for relaying data between a low earth orbit (LEO) satellite and a target ground station, where the HTS provides spot beams for a spot beam coverage area. The method of operating the HTS includes: determining an estimated trajectory of an orbiting LEO satellite; assigning a plurality of assigned spot beams having a matching color re-use polarization; and transmitting assignments of the plurality of assigned spot beams to the high throughput satellite to cause the high throughput satellite to maintain the inter-satellite link via a first spot beam and one or more assigned subsequent spot beams having the matching color re-use polarization.

Abstract: Dual-band satellite communication systems and methods are described. A dual-band satellite communication system is described with an array of feeds. The array includes single band feeds and one or more multi-band feeds. The multi-band feeds provide dual-band spot beams. Dual-band spot beams include a first frequency band spot beam and a second frequency band spot beam. A spot beam layout may be provided when a shared reflector for the array of feeds is provided. The first frequency band beamwidth may be smaller than a second frequency band beamwidth and the number of multi-band feeds in the array of feeds may be less than the number of single band feeds.