Abstract: The present disclosure provides a method of predicting basal-like breast cancer recurrence in a patient comprising (a) determining the phosphorylation status of at least one protein in a biological sample obtained from the patient; (b) identifying the patient as having a high risk of basal-like breast cancer recurrence if the phosphorylation status of the at least one protein is over-phosphorylated or under-phosphorylated as compared to a control; and (c) optionally administering to the patient a therapeutically effective amount of a chemotherapeutic if the patient is classified as having a high risk of basal-like breast cancer recurrence. Also disclosed herein are methods of treating a patient wherein the patient has been identified as having a high risk of basal-like breast cancer recurrence and kits for use in predicting basal-like breast cancer recurrence and/or prognosing basal-like breast cancer.

Abstract: The present invention relates to protein markers for luminal A (LA)-like and luminal B1 (LB 1)-like breast cancer. Methods for differentiating LA-like and LB 1-like breast cancer in a ER-positive breast cancer subject are provided, such methods including the detection of levels of a variety of biomarkers for LA-like and LB 1-like breast cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Abstract: Methods for prognosing the risk of progression in a ER-positive breast cancer (e.g., luminal B 1 breast cancer) subject are provided, such methods including the detection of levels of a variety of biomarkers prognostic of progression. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Abstract: Provided herein include a method, kit and system capable of detecting one or multiple human cancers with high accuracy. After an expression profile of an miRNA biomarker set comprising one or more miRNAs is determined based on a liquid biopsy sample from a subject, a diagnostic index is calculated, based on which the subject can be classified as having cancer or not. In the miRNA biomarker set, each miRNA is picked from a 500-miRNA set. A 4-miRNA biomarker model demonstrates exceptionally high sensitivities of 99.0-100% for lung and gastric cancers, 83.0-99.0% for biliary tract, bladder, colorectal, esophageal, glioma, liver, pancreatic, and prostate cancers, and 68.2-72.0% for ovarian cancer and sarcoma, while maintaining 99.3% specificity.

Abstract: The present invention discloses a polypeptide compound, a pharmaceutical composition, and a preparation method and use thereof. The structural formula of the polypeptide compound is shown in general formula (I): Such polypeptide compounds as ?-opioid receptor agonists have the advantages of better activity and the potential to become clinical candidate compounds.

Abstract: Satellite communication methods and payloads are described. The payload and methods are designed to enable effective use of carrier signals in the guard band region of a channelized band of spectrum. An on-board digital channelizer may implement a band edge power monitor for measuring power spectral density in the band edges of a channel and, if it exceeds a preset threshold level, downscaling the signal amplitude in the band edges to prevent hardware damage to the payload. The channelizer may further implement a band edge gain adjustment filter for shaping the overall frequency response to flatten the response across adjacent channels, including through the guard band region between the passbands of the adjacent channels.

Abstract: Satellite communication methods and payloads are described. The payload and methods are designed to enable effective use of carrier signals in the guard band region of a channelized band of spectrum. An on-board digital channelizer may implement a band edge power monitor for measuring power spectral density in the band edges of a channel and, if it exceeds a preset threshold level, downscaling the signal amplitude in the band edges to prevent hardware damage to the payload. The channelizer may further implement a band edge gain adjustment filter for shaping the overall frequency response to flatten the response across adjacent channels, including through the guard band region between the passbands of the adjacent channels.

Abstract: The present invention relates to protein markers for ER-positive-like and ER-negative-like breast cancer. Methods for differentiating ER-positive-like and ER-negative-like breast cancer in a subject having breast cancer are provided, such methods including the detection of levels of a variety of biomarkers for ER-positive-like and ER-negative-like breast cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Abstract: The application relates to an aircraft, a method, an apparatus and a computer readable storage medium for controlling the aircraft with at least one sensor arranged thereon, the method including detecting a motor state of the aircraft, acquiring at least one sensing data of the at least one sensor, and controlling the aircraft to perform a startup operation or a shutdown operation according to the motor state and the at least one sensing data, so that the aircraft can be autonomously controlled to perform the startup operation or the shutdown operation, and the user experience is improved.

Abstract: Provided are methods for cancer therapy. The method comprises inhibiting the expression and/or activity of ATF7IP and/or SETDB1 in cancer cells. Also provided is a method for identifying individuals for cancer therapy that includes using ATF7IP and/or SETDB1 inhibition.

Abstract: The present disclosure provides gene expression profiles that are associated with cancer, including certain gene expression profiles that differentiate between cancer that is at a high risk of recurrence. The gene expression profiles can be measured at the nucleic acid or protein level. The gene expression profiles can also be used to identify a subject for cancer treatment. Also provided are kits for use in predicting cancer recurrence and/or prognosing cancer and an array comprising probes for detecting the unique gene expression profiles associated with cancer.

Abstract: The present invention discloses a polypeptide compound, a pharmaceutical composition, and a preparation method and use thereof. The structural formula of the polypeptide compound is shown in general formula (I): Such polypeptide compounds as ?-opioid receptor agonists have the advantages of better activity and the potential to become clinical candidate compounds.

Abstract: A high throughput satellite (HTS) and a method of operating the HTS for relaying data between a low earth orbit (LEO) satellite and a target ground station, where the HTS provides spot beams for a spot beam coverage area. The method of operating the HTS includes: determining an estimated trajectory of an orbiting LEO satellite; assigning a plurality of assigned spot beams having a matching color re-use polarization; and transmitting assignments of the plurality of assigned spot beams to the high throughput satellite to cause the high throughput satellite to maintain the inter-satellite link via a first spot beam and one or more assigned subsequent spot beams having the matching color re-use polarization.

Abstract: A geolocation method and system for locating the source of interference to a high throughput satellite. The method involves determining relative power level differences between interference signals received by the victim spot beam and co-colored nearby spot beams on the same satellite. Using beam pattern data, the relative power levels for a pair of beams determines contour lines of possible location the correspond to the relative power difference in the signals received by the two beams in the pair. A point of intersection of contour lines from multiple pairs of spot beams indicates the location of the source of interference.

Abstract: The application relates to an aircraft, a method, an apparatus and a computer readable storage medium for controlling the aircraft with at least one sensor arranged thereon, the method including detecting a motor state of the aircraft, acquiring at least one sensing data of the at least one sensor, and controlling the aircraft to perform a startup operation or a shutdown operation according to the motor state and the at least one sensing data, so that the aircraft can be autonomously controlled to perform the startup operation or the shutdown operation, and the user experience is improved.

Abstract: A high throughput satellite (HTS) and a method of operating the HTS for relaying data between a low earth orbit (LEO) satellite and a target ground station, where the HTS provides spot beams for a spot beam coverage area. The method of operating the HTS includes: determining an estimated trajectory of an orbiting LEO satellite; assigning a plurality of assigned spot beams having a matching color re-use polarization; and transmitting assignments of the plurality of assigned spot beams to the high throughput satellite to cause the high throughput satellite to maintain the inter-satellite link via a first spot beam and one or more assigned subsequent spot beams having the matching color re-use polarization.

Abstract: A system for battery current monitoring includes a system power throttle stored in memory and executable by the one or more processors to place a battery of an electronic device into a state of expected zero-drain throughout a time interval while the electronic device remains active, and a battery leakage monitor stored in the memory and executable by the one or more processors to detect a battery charge leak based on a series of time-separated parameter measurements for the battery collected during the time interval.

Abstract: Dual-band satellite communication systems and methods are described. A dual-band satellite communication system is described with an array of feeds. The array includes single band feeds and one or more multi-band feeds. The multi-band feeds provide dual-band spot beams. Dual-band spot beams include a first frequency band spot beam and a second frequency band spot beam. A spot beam layout may be provided when a shared reflector for the array of feeds is provided. The first frequency band beamwidth may be smaller than a second frequency band beamwidth and the number of multi-band feeds in the array of feeds may be less than the number of single band feeds.

Abstract: A high throughput satellite and a method of operating a high throughput satellite. The satellite has multiple modes of operation and transitions between them in response to the spectrum fill rate. Modes of operation may include altering color re-use patterns to increase or reduce number of colors, using intra-beam geographic sub-division, or precoding downlink signals.

Abstract: A high throughput satellite and a method of operating a high throughput satellite. The satellite has multiple modes of operation and transitions between them in response to the spectrum fill rate. Modes of operation may include altering color re-use patterns to increase or reduce number of colors, using intra-beam geographic sub-division, or precoding downlink signals.