Patents by Inventor Hai Quang Tran
Hai Quang Tran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240014179Abstract: A system includes an image sensor structure and a flow cell. The image sensor structure includes an image layer disposed over a base substrate. A device stack is disposed over the image layer. A bond pad is disposed in the device stack. A passivation stack is disposed over the device stack and the bond pad. An array of nanowells is disposed in a top layer of the passivation stack. A through-silicon via (TSV) is in electrical contact with the bond pad. The TSV extends through the base substrate. A redistribution layer (RDL) is disposed on a bottom surface of the base substrate. The RDL is in electrical contact with the TSV. The flow cell is disposed upon the top layer of the passivation stack to form a flow channel therebetween. The flow channel is disposed over the array of nanowells and the bond pad.Type: ApplicationFiled: September 20, 2023Publication date: January 11, 2024Applicant: Illumina, Inc.Inventors: Tracy Helen FUNG, Hai Quang TRAN
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Publication number: 20240001361Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.Type: ApplicationFiled: September 18, 2023Publication date: January 4, 2024Inventors: Sebastian Bohm, Alex Aravanis, Alexander Hsiao, Behnam Javanmardi, Tarun Kumar Khurana, Hai Quang Tran, Majid Aghababazadeh, M. Shane Bowen, Boyan Boyanov, Dale Buermann
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Patent number: 11786898Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.Type: GrantFiled: March 13, 2020Date of Patent: October 17, 2023Assignee: ILLUMINA, INC.Inventors: Sebastian Bohm, Alex Aravanis, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Hai Quang Tran, Majid Aghababazadeh, M. Shane Bowen, Boyan Boyanov, Dale Buermann
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Patent number: 11784161Abstract: A system includes an image sensor structure and a flow cell. The image sensor structure includes an image layer disposed over a base substrate. A device stack is disposed over the image layer. A bond pad is disposed in the device stack. A passivation stack is disposed over the device stack and the bond pad. An array of nanowells is disposed in a top layer of the passivation stack. A through-silicon via (TSV) is in electrical contact with the bond pad. The TSV extends through the base substrate. A redistribution layer (RDL) is disposed on a bottom surface of the base substrate. The RDL is in electrical contact with the TSV. The flow cell is disposed upon the top layer of the passivation stack to form a flow channel therebetween. The flow channel is disposed over the array of nanowells and the bond pad.Type: GrantFiled: November 2, 2020Date of Patent: October 10, 2023Assignee: ILLUMINA, INC.Inventors: Tracy Helen Fung, Hai Quang Tran
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Publication number: 20230272469Abstract: An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.Type: ApplicationFiled: May 9, 2023Publication date: August 31, 2023Inventors: Sean M. Ramirez, Brian D. Mather, Edwin Li, Sojeong Moon, Innsu Daniel Kim, Alexandre Richez, Ludovic Vincent, Xavier von Hatten, Hai Quang Tran, Maxwell Zimmerley, Julia Morrison, Gianluca Andrea Artioli, Krystal Sly, Hayden Black, Lewis J. Kraft, Hong Xie, Wei Wei, Ryan Sanford
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Patent number: 11673319Abstract: A three-dimensional printing system includes a resin vessel, a support plate, a light engine, a build tray, motorized support, and a controller. The resin vessel includes a vessel body defining a central opening and a transparent sheet that closes the central opening. The transparent sheet is at least partially formed from a cast polypropylene (CPP). The support plate is for supporting the resin vessel and includes a rigid transparent central portion for supporting the transparent sheet. The light engine is configured to project pixelated light to a build plane within the resin. The build tray defines a support surface for supporting the three-dimensional article to be at least partially submerged in the resin. The motorized support is configured to align and adjust a vertical position of the build tray. The controller is for controlling the light engine and the motorized support for fabricating the three-dimensional article.Type: GrantFiled: November 13, 2020Date of Patent: June 13, 2023Assignee: 3D SYSTEMS, INC.Inventor: Hai Quang Tran
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Patent number: 11667969Abstract: An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.Type: GrantFiled: May 2, 2018Date of Patent: June 6, 2023Assignees: Illumina, Inc., Illumina Cambridge Limited, Illumina Singapore Pte. Ltd.Inventors: Sean M. Ramirez, Brian D. Mather, Edwin Li, Sojeong Moon, Innsu Daniel Kim, Alexandre Richez, Ludovic Vincent, Xavier von Hatten, Hai Quang Tran, Maxwell Zimmerley, Julia Morrison, Gianluca Andrea Artioli, Krystal Sly, Hayden Black, Lewis J. Kraft, Hong Xie, Wei Wei, Ryan Sanford
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Publication number: 20230145389Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.Type: ApplicationFiled: December 22, 2022Publication date: May 11, 2023Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
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Patent number: 11590494Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.Type: GrantFiled: June 6, 2019Date of Patent: February 28, 2023Assignee: ILLUMINA, INC.Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
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Publication number: 20220250066Abstract: An interposer for a flow cell comprises a base layer having a first surface and a second surface opposite the first surface. The base layer comprises black polyethylene terephthalate (PET). A first adhesive layer is disposed on the first surface of the base layer. The first adhesive layer comprises methyl acrylic adhesive. A second adhesive layer is disposed on the second surface of the base layer. The second adhesive layer comprises methyl acrylic adhesive. A plurality of microfluidic channels extends through each of the base layer, the first adhesive layer, and the second adhesive layer.Type: ApplicationFiled: April 22, 2022Publication date: August 11, 2022Applicant: ILLUMINA, Inc.Inventors: Maxwell Zimmerley, LiangLiang Qiang, M. Shane Bowen, Steven H. Modiano, Dajun Yuan, Randall Smith, Arthur J. Pitera, Hai Quang Tran, Gerald Kreindl
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Publication number: 20210146611Abstract: A three-dimensional printing system includes a resin vessel, a support plate, a light engine, a build tray, motorized support, and a controller. The resin vessel includes a vessel body defining a central opening and a transparent sheet that closes the central opening. The transparent sheet is at least partially formed from a cast polypropylene (CPP). The support plate is for supporting the resin vessel and includes a rigid transparent central portion for supporting the transparent sheet. The light engine is configured to project pixelated light to a build plane within the resin. The build tray defines a support surface for supporting the three-dimensional article to be at least partially submerged in the resin. The motorized support is configured to align and adjust a vertical position of the build tray. The controller is for controlling the light engine and the motorized support for fabricating the three-dimensional article.Type: ApplicationFiled: November 13, 2020Publication date: May 20, 2021Inventor: Hai Quang Tran
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Publication number: 20210050329Abstract: A system includes an image sensor structure and a flow cell. The image sensor structure includes an image layer disposed over a base substrate. A device stack is disposed over the image layer. A bond pad is disposed in the device stack. A passivation stack is disposed over the device stack and the bond pad. An array of nanowells is disposed in a top layer of the passivation stack. A through-silicon via (TSV) is in electrical contact with the bond pad. The TSV extends through the base substrate. A redistribution layer (RDL) is disposed on a bottom surface of the base substrate. The RDL is in electrical contact with the TSV. The flow cell is disposed upon the top layer of the passivation stack to form a flow channel therebetween. The flow channel is disposed over the array of nanowells and the bond pad.Type: ApplicationFiled: November 2, 2020Publication date: February 18, 2021Inventors: Tracy Helen FUNG, Hai Quang TRAN
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Publication number: 20210023786Abstract: A three-dimensional printing system includes a resin vessel, a light engine, a build tray, motorized support, and a controller. The resin vessel includes a vessel body defining a central opening and a transparent sheet that closes the central opening. The transparent sheet is at least partially formed from a cyclic olefin polymer (COP) that is synthesized in part by applying a ring-opening metathesis polymerization (ROMP) to a monomer. The light engine is configured to project pixelated light through the transparent sheet and to a build plane within the resin. The build tray defines a support surface for supporting the three-dimensional article to be at least partially submerged in the resin. The motorized support is configured to align and adjust a vertical position of the build tray. The controller is for controlling the light engine and the motorized support for fabricating the three-dimensional article.Type: ApplicationFiled: July 24, 2020Publication date: January 28, 2021Inventor: Hai Quang Tran
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Patent number: 10861829Abstract: A system includes an image sensor structure and a flow cell. The image sensor structure includes an image layer disposed over a base substrate. A device stack is disposed over the image layer. A bond pad is disposed in the device stack. A passivation stack is disposed over the device stack and the bond pad. An array of nanowells is disposed in a top layer of the passivation stack. A through-silicon via (TSV) is in electrical contact with the bond pad. The TSV extends through the base substrate. A redistribution layer (RDL) is disposed on a bottom surface of the base substrate. The RDL is in electrical contact with the TSV. The flow cell is disposed upon the top layer of the passivation stack to form a flow channel therebetween. The flow channel is disposed over the array of nanowells and the bond pad.Type: GrantFiled: December 26, 2017Date of Patent: December 8, 2020Assignee: ILLUMINA, INC.Inventors: Tracy Helen Fung, Hai Quang Tran
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Publication number: 20200206737Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.Type: ApplicationFiled: March 13, 2020Publication date: July 2, 2020Inventors: Sebastian Bohm, Alex Aravanis, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Hai Quang Tran, Majid Aghababazadeh, M. Shane Bowen, Boyan Boyanov, Dale Buermann
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Patent number: 10596569Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.Type: GrantFiled: June 3, 2015Date of Patent: March 24, 2020Assignee: ILLUMINA, INC.Inventors: Sebastian Bohm, Alex Aravanis, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Hai Quang Tran, Majid Aghababazadeh, M. Shane Bowen, Boyan Boyanov, Dale Buermann
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Publication number: 20200066684Abstract: A system includes an image sensor structure and a flow cell. The image sensor structure includes an image layer disposed over a base substrate. A device stack is disposed over the image layer. A bond pad is disposed in the device stack. A passivation stack is disposed over the device stack and the bond pad. An array of nanowells is disposed in a top layer of the passivation stack. A through-silicon via (TSV) is in electrical contact with the bond pad. The TSV extends through the base substrate. A redistribution layer (RDL) is disposed on a bottom surface of the base substrate. The RDL is in electrical contact with the TSV. The flow cell is disposed upon the top layer of the passivation stack to form a flow channel therebetween. The flow channel is disposed over the array of nanowells and the bond pad.Type: ApplicationFiled: December 26, 2017Publication date: February 27, 2020Applicant: ILLUMINA, INC.Inventors: Tracy Helen FUNG, Hai Quang TRAN
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Publication number: 20200009556Abstract: An interposer for a flow cell comprises a base layer having a first surface and a second surface opposite the first surface. The base layer comprises black polyethylene terephthalate (PET). A first adhesive layer is disposed on the first surface of the base layer. The first adhesive layer comprises methyl acrylic adhesive. A second adhesive layer is disposed on the second surface of the base layer. The second adhesive layer comprises methyl acrylic adhesive. A plurality of microfluidic channels extends through each of the base layer, the first adhesive layer, and the second adhesive layer.Type: ApplicationFiled: June 28, 2019Publication date: January 9, 2020Applicant: ILLUMINA, Inc.Inventors: Maxwell Zimmerley, LiangLiang Qiang, M. Shane Bowen, Steven H. Modiano, Dajun Yuan, Randall Smith, Arthur J. Pitera, Hai Quang Tran, Gerald Kreindl
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Patent number: 10427155Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.Type: GrantFiled: May 27, 2015Date of Patent: October 1, 2019Assignee: Illumina, Inc.Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
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Publication number: 20190283024Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.Type: ApplicationFiled: June 6, 2019Publication date: September 19, 2019Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran