Abstract: The present invention provides an antibody or a functional fragment thereof that specifically binds to IL-17A with high affinity. Also provided are a nucleic acid molecule encoding the antibody or the functional fragment thereof disclosed herein, an expression vector and a host cell for expressing the antibody or the functional fragment thereof disclosed herein, and a method for preparing the antibody or the functional fragment thereof disclosed herein. The present invention also provides a pharmaceutical composition comprising the antibody or the functional fragment thereof disclosed herein, and use of the antibody or the functional fragment thereof disclosed herein for treating an immune dysfunction disease.

Abstract: The present invention relates to an anti-BTLA antibody or an antigen-binding fragment thereof comprising: at least one light chain CDR domain selected from SEQ ID NOs: 7, 8, 9, 10, 11, 12, 16, 17, 18, 22, 23, 24, 31, 32 and 33, and/or at least one heavy chain CDR domain selected from SEQ ID NOs: 1, 2, 3, 4, 5, 6, 13, 14, 15, 19, 20, 21, 25, 26, 27, 28, 29 and 30. The present invention also relates to a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, a corresponding expression vector and a host cell, as well as therapeutic use of the antibody or the antigen-binding fragment thereof, the nucleic acid molecule, the expression vector and the host cell.

Abstract: An pressure regulating valve assembly for a pneumatic spray gun is disclosed. The pressure regulating vale component is configured inside the pressure regulating passage of the gun body, comprising a pressure regulating screw seat, a pressure regulating rod going through the pressure regulating screw seat and in threaded connection with the pressure regulating screw seat. A pressure regulating seal ring is configured between the pressure regulating rod and the pressure regulating screw seat. A clamping check ring is configured in the middle portion of the pressure regulating rod. The clamping check ring is used to limit the position of the pressure regulating rod. The inner end of the pressure regulating rod is provided with a pressure regulating valve. The position of the pressure regulating valve is limited by the split damping ring configured on the end portion of the pressure regulating rod.

Abstract: A humidifier for humidification of air to be delivered to a patient's airways may include a humidification chamber, a reservoir and a water delivery mechanism. The humidification chamber may include a water retention feature such as a wick, a heating element for heating the humidification chamber, and an air flow baffle configured to promote humidification. The humidifier may be further configured to execute one or more algorithms, for example to determine a condition of the humidifier and/or to mitigate any detected faults. In some forms, the humidifier may also comprise algorithms for controlling one or more components of the humidifier.

Abstract: Provided are a CLDN-18.2 specific binding antibody or an antigen binding fragment thereof, and a composition comprising same. Also provided are a nucleic acid molecule coding the antibody or the antigen binding fragment thereof, an expression vector and a host cell for expressing the antibody or the antigen binding fragment thereof, and a therapeutic or diagnostic method and use for the antibody or the antigen binding fragment thereof.

Abstract: An improved amplitude-modulating assembly for pneumatic spray guns. The amplitude-modulating assembly is configured inside the amplitude-modulating passage of the gun body, comprising an amplitude-modulating screw seat fixed with the gun body, and an amplitude-modulating rod going through the amplitude-modulating screw seat and in threaded connection with the amplitude-modulating screw seat. An amplitude-modulating seal ring is configured between the amplitude-modulating rod and the amplitude-modulating screw seat. The middle portion of the amplitude-modulating rod is configured with a clamping check ring. The clamping check ring is used to limit the position of the amplitude-modulating rod. The inner end of the amplitude-modulating rod is the amplitude-modulating portion. The amplitude-modulating portion is formed with a first inclined surface and a second inclined surface tilting toward the axis.

Abstract: A switch valve for comfortable use of pneumatic spray guns. The switch valve is configured inside the switch passage of the gun body, comprising a switch screw seat fixed with the gun body, a switch seat configured on the right side of the switch screw seat, an air valve configured in the middle portion of the switch screw seat and the switch seat, a switch spring configured on the right end of the air valve. The air valve and the switch seat interact to open or close the air passage. The size of the switch spring is smaller than the switch passage. A switch spring pad is configured on the right side of the switch spring.

Abstract: An pressure regulating valve assembly for a pneumatic spray gun is disclosed. The pressure regulating vale component is configured inside the pressure regulating passage of the gun body, comprising a pressure regulating screw seat, a pressure regulating rod going through the pressure regulating screw seat and in threaded connection with the pressure regulating screw seat. A pressure regulating seal ring is configured between the pressure regulating rod and the pressure regulating screw seat. A clamping check ring is configured in the middle portion of the pressure regulating rod. The clamping check ring is used to limit the position of the pressure regulating rod. The inner end of the pressure regulating rod is provided with a pressure regulating valve. The position of the pressure regulating valve is limited by the split damping ring configured on the end portion of the pressure regulating rod.

Abstract: A humidifier for humidification of air to be delivered to a patient's airways may include a humidification chamber, a reservoir and a water delivery mechanism. The humidification chamber may include a water retention feature such as a wick, a heating element for heating the humidification chamber, and an air flow baffle configured to promote humidification. The humidifier may be further configured to execute one or more algorithms, for example to determine a condition of the humidifier and/or to mitigate any detected faults. In some forms, the humidifier may also comprise algorithms for controlling one or more components of the humidifier.

Abstract: An antibody specifically binding to CTLA-4 or an antigen-binding fragment thereof, and a composition comprising same. Also provided are a nucleic acid molecule encoding the antibody or an antigen-binding fragment thereof, a vector and a host cell for expressing the antibody or an antigen-binding fragment thereof, and therapcutic and diagnostic methods and the use of the antibody or an antigen-binding fragment thereof.

Abstract: The present disclosure relates to use of an anti-PD-1 antibody and/or an antigen-binding fragment thereof in the treatment of a neuroendocrine neoplasm. The present disclosure also relates to an agent or a kit for detecting an ARID1A gene mutation or amplification, or a chromosomal gene rearrangement, and use of the detection agent or kit in predicting the therapeutic effect of an anti-PD-1 antibody or an antigen-binding fragment thereof in the treatment of a patient with a neuroendocrine neoplasm.

Abstract: The present invention provides an antibody or a functional fragment thereof that specifically binds to IL-17A with high affinity. Also provided are a nucleic acid molecule encoding the antibody or the functional fragment thereof disclosed herein, an expression vector and a host cell for expressing the antibody or the functional fragment thereof disclosed herein, and a method for preparing the antibody or the functional fragment thereof disclosed herein. The present invention also provides a pharmaceutical composition comprising the antibody or the functional fragment thereof disclosed herein, and use of the antibody or the functional fragment thereof disclosed herein for treating an immune dysfunction disease.

Abstract: The present disclosure relates to use of an anti-PD-1 antibody and/or an antigen-binding fragment thereof in the treatment of a malignancy. In particular, the present disclosure relates to use of an anti-PD-1 antibody and/or an antigen-binding fragment thereof in the treatment of a sarcoma, alveolar soft part sarcoma, angiosarcoma and undifferentiated polymorphic sarcoma, and use of an anti-PD-1 antibody and/or an antigen-binding fragment thereof in the treatment of lymphoma.

Abstract: The present disclosure relates to use of an anti-PD-1 antibody in the treatment of melanoma. The present disclosure also relates to use of an agent for detecting BRAF, NRAS, and CDK4/CCND1 gene mutations in a detection kit for predicting the therapeutic effect of an anti-PD-1 antibody and/or an antigen-binding fragment thereof administered alone to a patient with melanoma.

Abstract: Disclosed are an anti-freezing agent for protecting a biological tissue from being damaged during a freezing treatment and a preparation method therefor. The method for preparing the anti-freezing agent involves mixing ethylene glycol, water and dimethylsulfoxide homogeneously to form a matrix, and then slowly adding sodium polyacrylate. The prepared anti-freezing agent is coated onto biological tissue during a freezing treatment such that damage to the biological tissue is reduced.

Abstract: Disclosed are apparatus, systems and devices for providing modular connectivity to a respiratory therapy device. Certain forms relate to an apparatus for supplying a flow of breathable gas at positive pressure for respiratory therapy comprising a pressure generator in a housing, at least one electrical connector to connect to a connectivity module, and a cavity for receiving the connectivity module. Different forms of connectivity module may be provided. This allows for flexibility of connectivity in a respiratory device while allowing for simple installation and removal of the connectivity module.

Abstract: An apparatus for humidification of air to be delivered to a patient's airways may include a reservoir, and a humidifier chamber. The humidifier chamber may include a humidifier wick and a heating element for heating the humidifier chamber. The humidifier wick may comprise a fibrous sheet material. The humidifier chamber and wick may be vertically oriented in use such that a first end of the wick is above the second end of the wick. A deioniser may be provided to deionise the liquid prior to the humidifier wick. The apparatus may pasteurise liquid to be delivered to the humidification wick.

Abstract: Provided are antibodies that bind specifically to TIGIT or antigen binding fragments of the antibodies and a composition thereof. Also provided are a nucleic acid molecule coding the antibodies or the antigen binding fragments thereof, an expression vector and a host cell for expressing the antibodies or the antigen binding fragments thereof, and therapeutic and diagnostic uses of the antibodies.

Abstract: An apparatus for humidification of air to be delivered to a patient's airways may include a reservoir, and a humidifier chamber. The humidifier chamber may include a humidifier wick and a heating element for heating the humidifier chamber. The humidifier wick may comprise a fibrous sheet material. The humidifier chamber and wick may be vertically oriented in use such that a first end of the wick is above the second end of the wick. A deioniser may be provided to deionise the liquid prior to the humidifier wick. The apparatus may pasteurise liquid to be delivered to the humidification wick.