Abstract: An antibody specifically binding to CTLA-4 or an antigen-binding fragment thereof, and a composition comprising same. Also provided are a nucleic acid molecule encoding the antibody or an antigen-binding fragment thereof, a vector and a host cell for expressing the antibody or an antigen-binding fragment thereof, and therapeutic and diagnostic methods and the use of the antibody or an antigen-binding fragment thereof.

Abstract: A switching device for a pneumatic spray gun, comprising a gun body, a switch rod movably installed back and forth within a switch channel of the gun body, a material adjustment nut screwed onto the rear end of the switch channel, and a material needle inserted into a central hole of the switch rod. The rear end of the switch rod is provided with a rear sealing ring, and the front end of the switch rod is provided with a front sealing ring and a switch sleeve. The switch sleeve presses the front sealing ring tightly. A valve spring is arranged between the material adjustment nut and the switch rod, with the front end of the valve spring abutting against the switch rod, and the rear end connected to the material adjustment nut via a flat washer and an O-shaped sealing ring.

Abstract: The present disclosure relates to communication methods. In one example method, a terminal device determines a first resource based on configuration information from a network device, where the first resource is a resource that cannot be used to transmit a downlink data channel and a demodulation reference signal of the downlink data channel. The terminal device determines a second resource based on downlink control information from the network device, where the second resource includes a resource used to transmit the downlink data channel and the demodulation reference signal of the downlink data channel. The terminal device determines a third resource based on the first resource and the second resource, where the third resource is a resource that is in the second resource and that is used to transmit the downlink data channel and the demodulation reference signal of the downlink data channel.

Abstract: The present invention provides an antibody or a functional fragment thereof that specifically binds to IL-17A with high affinity. Also provided are a nucleic acid molecule encoding the antibody or the functional fragment thereof disclosed herein, an expression vector and a host cell for expressing the antibody or the functional fragment thereof disclosed herein, and a method for preparing the antibody or the functional fragment thereof disclosed herein. The present invention also provides a pharmaceutical composition comprising the antibody or the functional fragment thereof disclosed herein, and use of the antibody or the functional fragment thereof disclosed herein for treating an immune dysfunction disease.

Abstract: The present invention relates to an anti-BTLA antibody or an antigen-binding fragment thereof comprising: at least one light chain CDR domain selected from SEQ ID NOs: 7, 8, 9, 10, 11, 12, 16, 17, 18, 22, 23, 24, 31, 32 and 33, and/or at least one heavy chain CDR domain selected from SEQ ID NOs: 1, 2, 3, 4, 5, 6, 13, 14, 15, 19, 20, 21, 25, 26, 27, 28, 29 and 30. The present invention also relates to a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, a corresponding expression vector and a host cell, as well as therapeutic use of the antibody or the antigen-binding fragment thereof, the nucleic acid molecule, the expression vector and the host cell.

Abstract: An pressure regulating valve assembly for a pneumatic spray gun is disclosed. The pressure regulating vale component is configured inside the pressure regulating passage of the gun body, comprising a pressure regulating screw seat, a pressure regulating rod going through the pressure regulating screw seat and in threaded connection with the pressure regulating screw seat. A pressure regulating seal ring is configured between the pressure regulating rod and the pressure regulating screw seat. A clamping check ring is configured in the middle portion of the pressure regulating rod. The clamping check ring is used to limit the position of the pressure regulating rod. The inner end of the pressure regulating rod is provided with a pressure regulating valve. The position of the pressure regulating valve is limited by the split damping ring configured on the end portion of the pressure regulating rod.

Abstract: Provided are a CLDN-18.2 specific binding antibody or an antigen binding fragment thereof, and a composition comprising same. Also provided are a nucleic acid molecule coding the antibody or the antigen binding fragment thereof, an expression vector and a host cell for expressing the antibody or the antigen binding fragment thereof, and a therapeutic or diagnostic method and use for the antibody or the antigen binding fragment thereof.

Abstract: A switch valve for comfortable use of pneumatic spray guns. The switch valve is configured inside the switch passage of the gun body, comprising a switch screw seat fixed with the gun body, a switch seat configured on the right side of the switch screw seat, an air valve configured in the middle portion of the switch screw seat and the switch seat, a switch spring configured on the right end of the air valve. The air valve and the switch seat interact to open or close the air passage. The size of the switch spring is smaller than the switch passage. A switch spring pad is configured on the right side of the switch spring.

Abstract: An pressure regulating valve assembly for a pneumatic spray gun is disclosed. The pressure regulating vale component is configured inside the pressure regulating passage of the gun body, comprising a pressure regulating screw seat, a pressure regulating rod going through the pressure regulating screw seat and in threaded connection with the pressure regulating screw seat. A pressure regulating seal ring is configured between the pressure regulating rod and the pressure regulating screw seat. A clamping check ring is configured in the middle portion of the pressure regulating rod. The clamping check ring is used to limit the position of the pressure regulating rod. The inner end of the pressure regulating rod is provided with a pressure regulating valve. The position of the pressure regulating valve is limited by the split damping ring configured on the end portion of the pressure regulating rod.

Abstract: An improved amplitude-modulating assembly for pneumatic spray guns. The amplitude-modulating assembly is configured inside the amplitude-modulating passage of the gun body, comprising an amplitude-modulating screw seat fixed with the gun body, and an amplitude-modulating rod going through the amplitude-modulating screw seat and in threaded connection with the amplitude-modulating screw seat. An amplitude-modulating seal ring is configured between the amplitude-modulating rod and the amplitude-modulating screw seat. The middle portion of the amplitude-modulating rod is configured with a clamping check ring. The clamping check ring is used to limit the position of the amplitude-modulating rod. The inner end of the amplitude-modulating rod is the amplitude-modulating portion. The amplitude-modulating portion is formed with a first inclined surface and a second inclined surface tilting toward the axis.

Abstract: An antibody specifically binding to CTLA-4 or an antigen-binding fragment thereof, and a composition comprising same. Also provided are a nucleic acid molecule encoding the antibody or an antigen-binding fragment thereof, a vector and a host cell for expressing the antibody or an antigen-binding fragment thereof, and therapcutic and diagnostic methods and the use of the antibody or an antigen-binding fragment thereof.

Abstract: The present disclosure relates to use of an anti-PD-1 antibody and/or an antigen-binding fragment thereof in the treatment of a neuroendocrine neoplasm. The present disclosure also relates to an agent or a kit for detecting an ARID1A gene mutation or amplification, or a chromosomal gene rearrangement, and use of the detection agent or kit in predicting the therapeutic effect of an anti-PD-1 antibody or an antigen-binding fragment thereof in the treatment of a patient with a neuroendocrine neoplasm.

Abstract: The present invention provides an antibody or a functional fragment thereof that specifically binds to IL-17A with high affinity. Also provided are a nucleic acid molecule encoding the antibody or the functional fragment thereof disclosed herein, an expression vector and a host cell for expressing the antibody or the functional fragment thereof disclosed herein, and a method for preparing the antibody or the functional fragment thereof disclosed herein. The present invention also provides a pharmaceutical composition comprising the antibody or the functional fragment thereof disclosed herein, and use of the antibody or the functional fragment thereof disclosed herein for treating an immune dysfunction disease.

Abstract: The present disclosure relates to use of an anti-PD-1 antibody and/or an antigen-binding fragment thereof in the treatment of a malignancy. In particular, the present disclosure relates to use of an anti-PD-1 antibody and/or an antigen-binding fragment thereof in the treatment of a sarcoma, alveolar soft part sarcoma, angiosarcoma and undifferentiated polymorphic sarcoma, and use of an anti-PD-1 antibody and/or an antigen-binding fragment thereof in the treatment of lymphoma.

Abstract: The present disclosure relates to use of an anti-PD-1 antibody in the treatment of melanoma. The present disclosure also relates to use of an agent for detecting BRAF, NRAS, and CDK4/CCND1 gene mutations in a detection kit for predicting the therapeutic effect of an anti-PD-1 antibody and/or an antigen-binding fragment thereof administered alone to a patient with melanoma.

Abstract: Provided are antibodies that bind specifically to TIGIT or antigen binding fragments of the antibodies and a composition thereof. Also provided are a nucleic acid molecule coding the antibodies or the antigen binding fragments thereof, an expression vector and a host cell for expressing the antibodies or the antigen binding fragments thereof, and therapeutic and diagnostic uses of the antibodies.

Abstract: The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of a humanized anti-DKK2 antibody, methods for providing anti-tumor immunity in a subject, methods of stimulating a T cell mediated immune response to a cell population or a tissue and suppressing tumor in a subject. Additionally, the current invention includes methods of diagnosing a cancer or a predisposition of developing a cancer or a metastasis and methods for determining the use of immunotherapy treatment or cancer vaccine for treating cancer. Furthermore, the invention encompasses a pharmaceutical composition for treating cancer as well as a kit for carrying out the aforementioned methods.

Abstract: The present invention relates to use of an anti-PD-1 antibody in the treatment of a tumor. The present invention also relates to use of a reagent for detecting a gene amplification in the chromosome 11q13 region in a test kit for predicting the therapeutic effect of the anti-PD-1 antibody and/or the antigen-binding fragment thereof on a tumor patient.