Abstract: YAP1 inhibitors and methods of treating a subject with a cancer that include administering a YAP1 inhibitor are disclosed. Also disclosed are methods for determining responsiveness to a YAP1 inhibitor in a subject, methods for diagnosing a tumor in a subject including determining the level of YAP1 expression, compositions that include YAP1 inhibitors, and methods of using those compositions.

Abstract: Devices, systems, and methods provide direct digitization and encoding of a parameter to be sensed or measured. Digitized readings are encoded into binary bits, which are acquired and handled by digital devices. An all-digital sensing device can be implemented in passive, active, or semi-passive forms, and in some embodiments includes a transducer, digitizer/encoder, reader, and transmitter. A transducer converts the parameter to be measured into a digitizable quantity, based on such as mechanical deformation, dielectric properties, or electromagnetic wave or acoustic-wave properties. A piezoelectric material transducer converts stress/pressure into resistance or voltage. A fiber-optic interferometer transducer converts pressure/temperature/PH into irradiation amplitude or wavelength shift in spectrum domain. Encoded binary or quasi-binary states are identified by a reader. Binary states have resolutions arranged according to a 2N format.

Abstract: Devices, systems, and methods provide direct digitization and encoding of a parameter to be sensed or measured. Digitized readings are encoded into binary bits, which are acquired and handled by digital devices. An all-digital sensing device can be implemented in passive, active, or semi-passive forms, and in some embodiments includes a transducer, digitizer/encoder, reader, and transmitter. A transducer converts the parameter to be measured into a digitizable quantity, based on such as mechanical deformation, dielectric properties, or electromagnetic wave or acoustic-wave properties. A piezoelectric material transducer converts stress/pressure into resistance or voltage. A fiber-optic interferometer transducer converts pressure/temperature/PH into irradiation amplitude or wavelength shift in spectrum domain. Encoded binary or quasi-binary states are identified by a reader. Binary states have resolutions arranged according to a 2N format.

Abstract: A global manager computer generates management instructions for a particular managed server within an administrative domain according to a set of rules. A global manager computer identifies a traffic midpoint device through which the provider managed server provides a service to a user device. The global manager determines a relevant rule from the set of rules that is applicable to communication between the provider managed server and the user device and generates a backend rule that is applicable to communication between the provider managed server and the traffic midpoint device. The global managed generates a backend function-level instruction including a reference to an actor-set authorized to communicate with the provider managed server to use the service. The global manager sends the backend function-level instruction to the provider managed server to configure the provider managed server to enforce the backend rule on communication with the actor-set including the traffic midpoint device.

Abstract: A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmuting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned on the tip of the micro-probe. The light signal excites the luminescent material so that the luminescent material emits a luminescent light signal. The luminescent light signal has a property value dependent on the pH or temperature being measured and reflects back through the shaft for being measured by a light signal measuring device. The immuno-based micro-probe includes a reflective material that has an effective refractive index dependent on the number of antigen-antibody bonds present on the reflective material.

Abstract: A global manager computer generates management instructions for a particular managed server within an administrative domain according to a set of rules. A global manager computer identifies a traffic midpoint device through which the provider managed server provides a service to a user device. The global manager determines a relevant rule from the set of rules that is applicable to communication between the provider managed server and the user device and generates a backend rule that is applicable to communication between the provider managed server and the traffic midpoint device. The global managed generates a backend function-level instruction including a reference to an actor-set authorized to communicate with the provider managed server to use the service. The global manager sends the backend function-level instruction to the provider managed server to configure the provider managed server to enforce the backend rule on communication with the actor-set including the traffic midpoint device.

Abstract: An optical carrier based microwave interferometry (OCMI) system for measuring a physical, chemical, or biological property broadly comprises an optical carrier signal source, a waveguide, a microwave envelope signal source, a microwave modulator, an optical interferometer, a detector, and an analyzer. An optical carrier signal is modulated with a microwave envelope signal and transmitted through an optical interferometer. The optical signal is interrogated in microwave domain to obtain interference patterns or absorption/emission spectra corresponding to the physical, chemical, or biological property being measured.

Abstract: A global manager computer generates management instructions for a particular managed server within an administrative domain according to a set of rules. A global manager computer identifies a traffic midpoint device through which the provider managed server provides a service to a user device. The global manager determines a relevant rule from the set of rules that is applicable to communication between the provider managed server and the user device and generates a backend rule that is applicable to communication between the provider managed server and the traffic midpoint device. The global managed generates a backend function-level instruction including a reference to an actor-set authorized to communicate with the provider managed server to use the service. The global manager sends the backend function-level instruction to the provider managed server to configure the provider managed server to enforce the backend rule on communication with the actor-set including the traffic midpoint device.

Abstract: A device and method include a broadband light source in communication with a waveguide to provide a light signal for interrogating each of a plurality for sensors within the waveguide. An analyzer modulates the light signal with a microwave signal and demodulates and evaluates light signals reflected by the sensors. An amplitude and a phase of each reflected signal from each sensor is distinguished in the time domain and the modulated signal is reconstructed in the frequency domain.

Abstract: A global manager computer generates management instructions for a particular managed server within an administrative domain according to a set of rules. A global manager computer identifies a traffic midpoint device through which the provider managed server provides a service to a user device. The global manager determines a relevant rule from the set of rules that is applicable to communication between the provider managed server and the user device and generates a backend rule that is applicable to communication between the provider managed server and the traffic midpoint device. The global managed generates a backend function-level instruction including a reference to an actor-set authorized to communicate with the provider managed server to use the service. The global manager sends the backend function-level instruction to the provider managed server to configure the provider managed server to enforce the backend rule on communication with the actor-set including the traffic midpoint device.

Abstract: A global manager computer generates management instructions for a particular managed server within an administrative domain according to a set of rules. A global manager computer identifies a traffic midpoint device through which the provider managed server provides a service to a user device. The global manager determines a relevant rule from the set of rules that is applicable to communication between the provider managed server and the user device and generates a backend rule that is applicable to communication between the provider managed server and the traffic midpoint device. The global managed generates a backend function-level instruction including a reference to an actor-set authorized to communicate with the provider managed server to use the service. The global manager sends the backend function-level instruction to the provider managed server to configure the provider managed server to enforce the backend rule on communication with the actor-set including the traffic midpoint device.

Abstract: A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmitting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned on the tip of the micro-probe. The light signal excites the luminescent material so that the luminescent material emits a luminescent light signal. The luminescent light signal has a property value dependent on the pH or temperature being measured and reflects back through the shaft for being measured by a light signal measuring device. The immuno-based micro-probe includes a reflective material that has an effective refractive index dependent on the number of antigen-antibody bonds present on the reflective material.

Abstract: A microresonator structure comprises a waveguide and a microsphere. The waveguide is of elongated cylindrical shape and includes a first section of optical transmission material and a cavity section axially aligned with the first section. The cavity section includes a first cavity and a second cavity. The first cavity is adjacent to the first section and includes a first sidewall of optical transmission material with an inner surface that tapers inward to an apex positioned adjacent to the first section. The second cavity is positioned adjacent to the first cavity of hollow cylindrical shape and includes a circumferential second sidewall of optical transmission material that abuts the first sidewall. The microsphere has a spherical outer surface and is positioned within the cavity section such that the outer surface contacts a portion of the first sidewall and a portion of the second sidewall.

Abstract: A coaxial cable sensor device with periodic impedance discontinuities along the length of its cable. The cable comprises an inner conductor, insulating material disposed around the length of the inner conductor, and an outer conductor disposed around the insulating material. The periodic impedance discontinuities are created by physical deformations or material alterations to at least one of the inner conductor, the outer conductor, and the insulating material. The sensor device may be used to measure temperature, pressure, strain, and acoustic waves in building structures, and is well suited for down-hole or underwater applications.

Abstract: A device and method include a broadband light source in communication with a waveguide to provide a light signal for interrogating each of a plurality for sensors within the waveguide. An analyzer modulates the light signal with a microwave signal and demodulates and evaluates light signals reflected by the sensors. An amplitude and a phase of each reflected signal from each sensor is distinguished in the time domain and the modulated signal is reconstructed in the frequency domain.

Abstract: An optical carrier based microwave interferometry (OCMI) system for measuring a physical, chemical, or biological property broadly comprises an optical carrier signal source, a waveguide, a microwave envelope signal source, a microwave modulator, an optical interferometer, a detector, and an analyzer. An optical carrier signal is modulated with a microwave envelope signal and transmitted through an optical interferometer. The optical signal is interrogated in microwave domain to obtain interference patterns or absorption/emission spectra corresponding to the physical, chemical, or biological property being measured.

Abstract: A microresonator structure comprises a waveguide and a microsphere. The waveguide is of elongated cylindrical shape and includes a first section of optical transmission material and a cavity section axially aligned with the first section. The cavity section includes a first cavity and a second cavity. The first cavity is adjacent to the first section and includes a first sidewall of optical transmission material with an inner surface that tapers inward to an apex positioned adjacent to the first section. The second cavity is positioned adjacent to the first cavity of hollow cylindrical shape and includes a circumferential second sidewall of optical transmission material that abuts the first sidewall. The microsphere has a spherical outer surface and is positioned within the cavity section such that the outer surface contacts a portion of the first sidewall and a portion of the second sidewall.

Abstract: A manufacturing apparatus for a backlight unit includes a feed mechanism, a testing mechanism, and an attachment mechanism. The feed mechanism arranges a plurality of light-emitting diodes in a row. The testing mechanism tests the light-emitting diodes. The attachment mechanism positions the light-emitting diodes to a circuit board. The attachment mechanism comprises a support assembly and a laminating device, in which the support assembly receives the light-emitting diodes tested by the at least one testing unit, the support assembly is opposite to the circuit board, and the laminating device laminates the light-emitting diodes to the circuit board. A method for manufacturing the backlight unit is also provided.

Abstract: A sprue device for an injection mold includes a first part and a second part. The sprue device is sealed and water-cooled so as to reduce overall molding time. The connecting section defines spiral grooves. The second part includes a chassis and an extension from the chassis. The chassis is defined with a through hole, and two gates communicated with the through hole respectively. The spiral grooves mate with the wall of the mounting hole to form a spiral runner. The gates, the through hole, and the spiral runner communicate with each other. An injection mold using the sprue device is also described.

Abstract: A sprue device for an injection mold includes a first part and a second part. The sprue device is sealed and water-cooled so as to reduce overall molding time. The connecting section defines spiral grooves. The second part includes a chassis and an extension from the chassis. The chassis is defined with a through hole, and two gates communicated with the through hole respectively. The spiral grooves mate with the wall of the mounting hole to form a spiral runner. The gates, the through hole, and the spiral runner communicate with each other. An injection mold using the sprue device is also described.