Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: A signal decision equalization method and apparatus are provided. The method includes: obtaining an input signal; determining a decision circuit of the input signal; obtaining a first group of decision thresholds and a first group of equalization expectations of the decision circuit; determining a decision value of the input signal based on the first group of equalization expectations, the first group of decision thresholds, and the input signal, and outputting the decision value; updating, based on the decision value and the input signal, a first equalization expectation that is in the first group of equalization expectations and that corresponds to the decision value to a second equalization expectation to obtain a second group of equalization expectations; and updating at least one decision threshold in the first group of decision thresholds based on the second equalization expectation to obtain a second group of decision thresholds.

Abstract: Embodiments of the present disclosure provide a method for recommending a podcast in music application and a device, where the method includes: a terminal device receives a start instruction for a podcast interface the music application; and the terminal device displays a first preset number of recommended podcast programs in the podcast interface in response to the start instruction, where each of the recommended podcast programs is an episode of audio data, and the recommended podcast programs include a podcast program matching with a preference of a user who uses the music application.

Abstract: The present invention discloses a high-entropy soft magnetic alloy with 900 K high-temperature resistance, comprising Fe, Co, Ni, Si and Al, and the atomic percent of the alloy composition is expressed as FexCoyNizSimAln, wherein x=40%-80%, y=20%-60%, z=0-30%, m=0-20%, n=0-20%, and x+y+z+m+n=100%; the atomic percent of other doping elements is p=0-5%, and 0.5?m/n?3; the performance indexes of the material include: at room temperature, saturation magnetization Ms=90-150 emu/g, and coercive force Hc=0.1-15 Oe; and at 900 K, saturation magnetization Ms=70-130 emu/g, and coercive force Hc=0.1-25 Oe.

Abstract: A semiconductor structure includes a substrate that includes a base, a plurality of channel layers on the base, and an isolation layer between each of the channel layers. The semiconductor structure also includes a gate on the substrate, spanning a top and a portion of sidewalls of the channel layers. The semiconductor structure also includes a sidewall structure on sidewalls at two sides of the gate, a source/drain region in the substrate at two sides of the gate and the sidewall structure, a source/drain electrical connection layer on the source/drain region, and an isolation structure between the source/drain electrical connection layer and the gate. The isolation structure includes a cavity, including a first cavity region and a second cavity region located on the first cavity region. A width of the second cavity region is smaller than a width of the first cavity region.

Abstract: A use of a ZmSBP12 gene in the regulation of drought resistance, plant height, and ear height of Zea mays L. is provided. After the ZmSBP12 gene is over-expressed in Zea mays L., the resulting Zea mays L. mutant plant exhibits increased drought resistance and decreased plant and ear heights. The overexpression of the ZmSBP12 gene leads to increased drought resistance and decreased plant and ear heights, indicating that the ZmSBP12 gene plays a crucial role in the drought resistance and plant type (plant height) of Zea mays L. The expression abundance of the ZmSBP12 gene is increased to improve the drought resistance of Zea mays L. and reduce the plant and ear heights of Zea mays L., which can be used for the assisted breeding of novel drought-resistant and lodging-resistant Zea mays L. varieties and the breeding of excellent inbred lines and hybrids of Zea mays L.

Abstract: An energetic composition and a method of unzipping polymer binders are disclosed, which includes localizing a heat feedback just near the reaction front by unzipping polymer binders employed to a nanothermite. The energetic composition includes an unzipping polymer binder employed to high load fuel and oxidizer particles.

Abstract: The present disclosure provides for the preparation and use of immunostimulatory conjugate complexes for targeted delivery and activation. In particular, the present disclosure provides compounds represented by the formula MI-S-C-A for use as linker, and drug-linked pharmaceutical compounds represented by the formula MI-S-C-A-D. The pharmaceutical compounds of the present disclosure have improved water solubility, reduced cytotoxicity, and enhanced pharmaceutical activity.

Abstract: Methods for inversion of seismic data to infer subsurface physical property parameters, comprising constructing an inhomogeneous anisotropy model and/or inhomogeneous VS/VP or VP/VS model; and inverting the seismic data in a sequential or simultaneous approach to obtain at least one subsurface physical property parameter using an elastic inversion algorithm and the inhomogeneous anisotropy model and/or inhomogeneous VS/VP or VP/VS model. Constructing an inhomogeneous anisotropy model may comprise deriving geobodies from at least one of seismic facies analysis, regional geologic information, or seismically derived earth models; and adjusting at least one of ?, ?, ?, or parameters of the elastic stiffness tensor matrix in a homogeneous anisotropy model in areas corresponding to the geobodies. Constructing an inhomogeneous VS/VP or VP/VS model may comprise deriving geobodies and adjusting values in a homogeneous VS/VP or VP/VS model in areas corresponding to the geobodies.

Abstract: Disclosed is a method for detecting a block chain abnormal behavior based on graph embedding. The method comprises S100: data collection: acquiring public block chain abnormal behavior node data on the Internet, and acquiring normal nodes in a number equal to that of abnormal behavior nodes at the same time; S200: establishment of abnormal behavior recognition model: extracting features of all nodes, constructing the nodes subjected to feature extraction into a transaction graph, and forming the abnormal behavior recognition model based on a graph embedding technology according to the constructed transaction graph; and S300: transaction detection: determining a transaction risk according to the obtained abnormal behavior recognition model when a transaction occurs, and prompting a user of a risk level. According to the method for detecting the block chain abnormal behavior based on graph embedding, abnormal behaviors possibly existing in block chain transactions can be effectively detected and early warned.

Abstract: Disclosed is a method for detecting a block chain abnormal behavior based on graph embedding. The method comprises S100: data collection: acquiring public block chain abnormal behavior node data on the Internet, and acquiring normal nodes in a number equal to that of abnormal behavior nodes at the same time; S200: establishment of abnormal behavior recognition model: extracting features of all nodes, constructing the nodes subjected to feature extraction into a transaction graph, and forming the abnormal behavior recognition model based on a graph embedding technology according to the constructed transaction graph; and S300: transaction detection: determining a transaction risk according to the obtained abnormal behavior recognition model when a transaction occurs, and prompting a user of a risk level. According to the method for detecting the block chain abnormal behavior based on graph embedding, abnormal behaviors possibly existing in block chain transactions can be effectively detected and early warned.

Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: Disclosed are conjugates of biomolecule and use thereof. The disclosed conjugates of biomolecule contain a biomolecule and a functional moiety covalently linked to the biomolecule. The functional moiety contains a group that prevents the biomolecule from binding to its ligand or receptor, a cleavable linker arm that can be activated by proteolytic enzymes or can be acidically activated in a microenvironment of a disease, a linker arm that will automatically shed after the cleavable linker arm is cleaved, and a group that maintains or promotes the binding capacity of the biomolecule to its ligand or receptor.

Abstract: A use of a ZmSBP12 gene in the regulation of drought resistance, plant height, and ear height of Zea mays L. is provided. After the ZmSBP12 gene is over-expressed in Zea mays L., the resulting Zea mays L. mutant plant exhibits increased drought resistance and decreased plant and ear heights. The overexpression of the ZmSBP12 gene leads to increased drought resistance and decreased plant and ear heights, indicating that the ZmSBP12 gene plays a crucial role in the drought resistance and plant type (plant height) of Zea mays L. The expression abundance of the ZmSBP12 gene is increased to improve the drought resistance of Zea mays L. and reduce the plant and ear heights of Zea mays L., which can be used for the assisted breeding of novel drought-resistant and lodging-resistant Zea mays L. varieties and the breeding of excellent inbred lines and hybrids of Zea mays L.

Abstract: A method may include obtaining an image including a face. The method may further include determining at least one time domain feature related to the face in the image and at least one frequency domain information related to the face in the image. The method may further include evaluating the quality of the image based on the at least one time domain feature and the frequency domain information.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for receiving usage data for a virtual device (or other virtual service), analyzing the usage data to determine a usage bucket characteristic of usage of the virtual device over a period of time, and determining a usage score for the virtual device. The systems described herein further involve causing a deployment of the virtual device to be upgraded, downgraded, or otherwise modified based on the usage bucket and associated usage score. The features and functionalities described herein can provide an efficient mechanism for administrating a tenant deployment as well as implementing a more efficient utilization of cloud computing resources for a variety of virtual services.

Abstract: A key DNA sequence for regulating a maize leaf angle and a mutant thereof are provided, which have polynucleotide sequences shown in SEQ ID No. 1 and SEQ ID No. 2, respectively. The DNA sequence for regulating a maize leaf angle and the mutant thereof provided by present disclosure can regulate the expression of ZmNAC16 gene in a maize pulvinus, and thus can be used for the improvement of maize leaf angle and plant type and further for the cultivation of new maize varieties. The present disclosure further provides specific detection primers for detecting mutations of the DNA key sequence and the mutant, and detection primers for detecting an expression level of ZmNAC16 gene in maize. These detection primers can be used to directionally improve a maize leaf angle and also shows application potential for breeding of dense-planting-tolerant and high-yield maize.

Abstract: The present disclosure discloses melatonin derivatives, a method thereof, and a use thereof. The method comprises: dissolving melatonin in a solvent, adding a catalyst while maintaining the solvent at 0° C. to obtain a first reaction solution, stirring the first reaction solution, adding reactants in the first reaction solution, continually stirring at room temperature or at refluxing reaction temperature until, when analyzing by thin layer chromatography, the first reaction solution is fully reacted, quenching the reaction with ice water, concentrating the first reaction solution to obtain a residue of the first reaction solution, and purifying the residue of the first reaction solution by column chromatography to obtain the melatonin derivatives.