Patents by Inventor Haibin Xia

Haibin Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA interference suppression of neurodegenerative diseases and methods of use
    Patent number: 10072264
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: September 11, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20170335318
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: December 30, 2016
    Publication date: November 23, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20160281084
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: November 3, 2015
    Publication date: September 29, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA interference suppression of neurodegenerative diseases and methods of use thereof
    Patent number: 9260716
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: February 16, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20140287492
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: June 18, 2013
    Publication date: September 25, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA interference suppresion of neurodegenerative diseases and methods of use thereof
    Patent number: 8524879
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: September 3, 2013
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan L. Boudreau, Scott Harper
  • RNA interference suppression of neurodegenerative diseases and methods of use thereof
    Patent number: 8481710
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: July 9, 2013
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20110212520
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: December 9, 2010
    Publication date: September 1, 2011
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
  • RNA INTERFERENCE SUPPRESION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF
    Publication number: 20110111491
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: May 5, 2010
    Publication date: May 12, 2011
    Applicant: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Henry Paulson, Ryan Boudreau, Scott Harper, Haibin Xia, Qinwen Mao
  • siRNA-MEDIATED GENE SILENCING WITH VIRAL VECTORS
    Publication number: 20100190243
    Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
    Type: Application
    Filed: August 24, 2009
    Publication date: July 29, 2010
    Applicant: University of lowa Research Foundation
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao
  • siRNA-mediated gene silencing with viral vectors
    Publication number: 20100144026
    Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
    Type: Application
    Filed: May 27, 2009
    Publication date: June 10, 2010
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao
  • siRNA-Mediated gene silencing with viral vectors
    Publication number: 20060009408
    Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
    Type: Application
    Filed: January 31, 2005
    Publication date: January 12, 2006
    Inventors: Beverly Davidson, Haibin Xia, Qinwen Mao
  • PTD-modified proteins
    Publication number: 20050112640
    Abstract: The present invention provides polynucleotides and expression vectors containing a sequence encoding a soluble lysosomal enzyme and a sequence encoding Tat protein transduction domain (PTD), and the corresponding polypeptides. The present demonstrates the utility of these protein fusions in altering the bioavailability of proteins for use in treating genetic diseases or acquired diseases. The invention further provides cell expression systems, and methods of treating a genetic disease or cancer in a mammal using the polynucleotides, polypeptides, or expression system of the present invention.
    Type: Application
    Filed: September 28, 2004
    Publication date: May 26, 2005
    Inventors: Beverly Davidson, Qinwen Mao, Haibin Xia
  • siRNA-mediated gene silencing with viral vectors
    Publication number: 20050106731
    Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
    Type: Application
    Filed: August 5, 2002
    Publication date: May 19, 2005
    Inventors: Beverly Davidson, Haibin Xia, Qinwen Mao
  • RNA interference suppresion of neurodegenerative diseases and methods of use thereof
    Publication number: 20050042646
    Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
    Type: Application
    Filed: June 2, 2004
    Publication date: February 24, 2005
    Inventors: Beverly Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau
  • Rapid generation of recombinant adenoviral vectors
    Patent number: 6830920
    Abstract: The invention provides a novel Adenovirus backbone plasmid, which when co-transfected with a shuttle vector, allows for production of recombinant viruses quickly and easily. The present invention also provides host cells and a cloning system for generating recombinant adenoviruses.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: December 14, 2004
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, Richard Anderson, Ronald Haskell, Haibin Xia
  • SiRNA-mediated gene silencing with viral vectors
    Publication number: 20040023390
    Abstract: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.
    Type: Application
    Filed: May 5, 2003
    Publication date: February 5, 2004
    Inventors: Beverly L. Davidson, Haibin Xia, Qinwen Mao
  • Receptor-targeted adenoviral vectors
    Publication number: 20030133912
    Abstract: The invention provides adenoviral vectors possessing fibers that do not bind CAR, a receptor-targeting ligand sequence, the non-receptor targeting sequence derived from HIV-TAT, a sequence encoding the HI loop of the non-CAR binding adenovirus fiber, which permits specific receptor-targeted transduction with the recombinant adenovirus vectors. The invention also provides related chimeric proteins, adenovirus particles and mammalian cells.
    Type: Application
    Filed: November 7, 2002
    Publication date: July 17, 2003
    Inventors: Beverly L. Davidson, Haibin Xia, Lane K. Law
  • PTD-modified proteins
    Publication number: 20020142299
    Abstract: The present invention provides polynucleotides and expression vectors containing a sequence encoding a soluble lysosomal enzyme and a sequence encoding Tat protein transduction domain (PTD), and the corresponding polypeptides. The present demonstrates the utility of these protein fusions in altering the bioavailability of proteins for use in treating genetic diseases or acquired diseases. The invention further provides cell expression systems, and methods of treating a genetic disease or cancer in a mammal using the polynucleotides, polypeptides, or expression system of the present invention.
    Type: Application
    Filed: January 9, 2001
    Publication date: October 3, 2002
    Inventors: Beverly L. Davidson, Qinwen Mao, Haibin Xia
  • Rapid generation of recombinant adenoviral vectors
    Publication number: 20020098571
    Abstract: The invention provides a novel Adenovirus backbone plasmid, which when co-transfected with a shuttle vector, allows for production of recombinant viruses quickly and easily. The present invention also provides host cells and a cloning system for generating recombinant adenoviruses.
    Type: Application
    Filed: March 8, 2000
    Publication date: July 25, 2002
    Inventors: Beverly L. Davidson, Richard Anderson, Ronald Haskell, Haibin Xia