Abstract: The present disclosure provides an innovative method for improving the enzyme activity of an NMN biosynthetic enzyme Nampt, and relates to the technical field of genetic engineering. A mutant protein of the present disclosure is obtained by firstly analyzing a target protein Nampt using two softwares FoldX and DeepDDG, and then predicting multiple key sites influencing the enzyme functions and finally performing the semi-rational design of the enzyme. In the examples of the present disclosure, 10 mutant strains are constructed using the designed primers according to the principle of point mutation, and 8 of the mutants have higher activity than a wild-type strain, in which the NMN yield of the mutant Nampt-V365L is increased by 62%, and the NMN yields of the mutants Nampt-S248A, Nampt-N164L, Nampt-S382M, Nampt-A245T and Nampt-A208G are increased by 34%, 27%, 27%, 22% and 17% respectively.

Abstract: A method includes obtaining a first image frame captured using at least one imaging sensor. The method also includes determining that an optical code is contained within the first image frame and determining whether to automatically zoom onto the optical code. The method further includes, in response to determining to automatically zoom onto the optical code, identifying a zoom ratio to be applied. In addition, the method includes controlling the at least one imaging sensor to capture a second image frame that is zoomed onto the optical code using the zoom ratio. Determining whether to automatically zoom onto the optical code includes identifying a distance between the optical code and a nearest edge or a nearest corner in the first image frame and determining to automatically zoom onto the optical code based on the identified distance being greater than a threshold distance.

Abstract: Disclosed in the present disclosure are a transfer reinforcement learning method and apparatus, multi-task reinforcement learning method and apparatus, relating to the field of intelligent control technology. The transfer reinforcement learning method includes determining operational instructions for instructing an agent to perform a first task; determining an inclusion relation between multiple second tasks and the first tasks based on the operational instructions; determining a shared parameter set corresponding to the multiple second tasks based on the inclusion relation between the multiple second tasks and the first task, wherein the shared parameter set includes a plurality of parameters shared by the multiple second tasks; and performing transfer reinforcement learning based on the shared parameter set and the first task to obtain model parameters of a target policy model corresponding to the first task.

Abstract: Disclosed are an analog-to-digital conversion circuit, an analog-to-digital conversion device, and a digital x-ray imaging system. The analog-to-digital conversion circuit includes a first reference voltage source, a second reference voltage source, a first analog-to-digital converter connected to the first reference voltage source, a second analog-to-digital converter connected to the second reference voltage source, a connecting circuit connected to the first analog-to-digital converter and the second analog-to-digital converter, respectively, and a current source having negative temperature coefficient configured to be connected to the first reference voltage source and the second reference voltage source, respectively.

Abstract: A bionic robot is provided, which includes a body; a plurality of sets of wheeled leg devices arranged at intervals in a front-rear direction, each comprising two wheeled leg devices arranged symmetrically in a left-right direction, each comprising a leg assembly and a travel wheel, and a power output shaft connected to the travel wheel; and a suspension device disposed in the body and connected to at least two sets from the plurality of sets of wheeled leg devices. The at least two sets of wheeled leg devices are located at the foremost end and the backmost end respectively. The suspension device comprises a plurality of drive assemblies, each connected to a corresponding leg assembly, which each comprise: an electric cylinder being configured to drive a telescopic rod to extend or retract; a damper connected between the body and the leg assembly; and an elastic member fitted over the damper.

Abstract: Through an intermediate I (a compound having the structural formula as shown in the formula Ia and/or the formula Ib), or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a tautomer Ic of Ib, a bicyclopyrone intermediate II with a high yield can be prepared. Two compounds are docked first under the action of a base to produce an intermediate I, and then the intermediate I is subjected to intramolecular ring closure by an ammonium salt, which can increase the yield of the bicyclopyrone intermediate (II), reduce side reactions, and reduce problems that a reaction of raw materials is easily incomplete due to intramolecular ring closure directly through an ammonium salt. A one-pot method includes producing an intermediate I under the action of a base and then performing a ring-closure reaction to produce a bicyclopyrone intermediate (II) that reduces side reactions, and further increases the yield.

Abstract: In one embodiment, a method includes receiving, at a proxy application on a first computing device, a request from a first application on the first computing device to access a resource. The method further includes transmitting, from the proxy application on the first computing device, a modified version of the request to a proxy application on a second computing device and receiving, from the proxy application on the second computing device, a response comprising data from the requested resource, where the resource is on the second computing device. The method further includes transmitting, to the first application on the first computing device, a response satisfying the first application's request to access the resource.

Abstract: The disclosure belongs to the technical field of photoelectric emission in semiconductors, and discloses an electro-absorption modulated laser chip and a fabrication method thereof, which can solve the problems of signal distortion caused by optical crosstalk between components in an existing electro-absorption modulated laser (EML) integrated with a semiconductor optical amplifier (SOA), and failure in longer-distance transmission.

Abstract: The disclosure belongs to the technical field of photoelectric emission in semiconductors, and discloses an electro-absorption modulated laser chip and a fabrication method thereof, which can solve the problems of signal distortion caused by optical crosstalk between components in an existing electro-absorption modulated laser (EML) integrated with a semiconductor optical amplifier (SOA), and failure in longer-distance transmission.

Abstract: Disclosed in the present disclosure are a method for training a multi-task model through multi-task reinforcement learning, an apparatus, an electronic device and a non-transitory computer readable storage medium. A method for training a multi-task model through multi-task reinforcement learning, including: acquiring observation signals observed for an environment by an agent; receiving T instructions each for instructing the agent to perform one of T tasks, T being a preset positive integer greater than 1; and generating K base policy models by performing training through multi-task reinforcement learning over a neural network based on the observation signals and the T instructions, wherein the K base policy models are combinable for generating respective task policy models for the T tasks to obtain the multi-task model for achieving the T tasks.

Abstract: The present disclosure relates to the technical field of daily necessities, and provides a urinal, a squatting pan and a pedestal pan. The special urinal comprises a urinal, a sewage discharge port, a water inlet and a water outlet hole. The urinal has a first end adjacent to the sewage discharge port and a second end away from the sewage discharge port; the sewage discharge port is provided at the bottom of the urinal, the water outlet hole is communicated with the water inlet, the urinal is internally provided with a protruding portion that is used for being opposite to the anus of a user; one end of the protruding portion extends to the bottom of the urinal; and the water outlet hole is used for flushing the protruding portion. The present disclosure aims to solve the defect in the prior art that a female urinal cannot distinguish stool from urine.

Abstract: The present disclosure relates to the technical field of daily necessities, and provides a urinal, a squatting pan and a pedestal pan. The special urinal comprises a urinal, a sewage discharge port, a water inlet and a water outlet hole. The urinal has a first end adjacent to the sewage discharge port and a second end away from the sewage discharge port; the sewage discharge port is provided at the bottom of the urinal, the water outlet hole is communicated with the water inlet, the urinal is internally provided with a protruding portion that is used for being opposite to the anus of a user; one end of the protruding portion extends to the bottom of the urinal; and the water outlet hole is used for flushing the protruding portion. The present disclosure aims to solve the defect in the prior art that a female urinal cannot distinguish stool from urine.

Abstract: Described herein are embodiments for fast training of adversarially robust models against adversarial attacks. Embodiments for model training by perturbing both the image and the label, which may be referred to as Bilateral Adversarial Training (BAT), are disclosed. To generate the adversarial label, one or more closed-form heuristic solutions are derived. One-step targeted attack is used with the target label being the most confusing class. It is shown in various experiments that random start and the most confusing target attack effectively prevent the label leaking and gradient masking problem. Coupled with the adversarial label part, embodiments of presented models significantly improve the state-of-the-art results. Experiments on one or more computationally challenging dataset also demonstrate the effectiveness of the presented BAT method embodiments.

Abstract: In one embodiment, a method includes receiving, at a proxy application on a first computing device, a request from a first application on the first computing device to access a resource. The method further includes transmitting, from the proxy application on the first computing device, a modified version of the request to a proxy application on a second computing device and receiving, from the proxy application on the second computing device, a response comprising data from the requested resource, where the resource is on the second computing device. The method further includes transmitting, to the first application on the first computing device, a response satisfying the first application’s request to access the resource.

Abstract: Described herein are embodiments for a feature-scattering-based adversarial training approach for improving model robustness against adversarial attacks. Conventional adversarial training approaches leverage a supervised scheme, either targeted or non-targeted in generating attacks for training, which typically suffer from issues such as label leaking as noted in recent works. Embodiments of the disclosed approach generate adversarial images for training through feature scattering in the latent space, which is unsupervised in nature and avoids label leaking. More importantly, the presented approaches generate perturbed images in a collaborative fashion, taking the inter-sample relationships into consideration. Extensive experiments on different datasets compared with state-of-the-art approaches demonstrate the effectiveness of the presented embodiments.

Abstract: A side-open left-right-door arbitrary-opening structure of a refrigerator comprises four hinge shafts are fixedly connected at left and right sides of a refrigerator body in pairs respectively, left and right sides of upper and lower end faces of a refrigerator door are all provided with an opening neck, each hinge shaft is correspondingly placed in one opening neck, four hinge shaft stoppers are slidably arranged on the upper and lower end faces of the refrigerator door in pairs respectively, one spring is arranged between two hinge shaft stoppers in each pair, tail ends of the hinge shaft stoppers on the upper and lower end faces of the refrigerator door extend into the opening necks at the corresponding sides, and the hinge shafts at the corresponding sides are positioned in the opening necks.

Abstract: The present disclosure provides an innovative method for improving the enzyme activity of an NMN biosynthetic enzyme Nampt, and relates to the technical field of genetic engineering. A mutant protein of the present disclosure is obtained by firstly analyzing a target protein Nampt using two softwares FoldX and DeepDDG, and then predicting multiple key sites influencing the enzyme functions and finally performing the semi-rational design of the enzyme. In the examples of the present disclosure, 10 mutant strains are constructed using the designed primers according to the principle of point mutation, and 8 of the mutants have higher activity than a wild-type strain, in which the NMN yield of the mutant Nampt-V365L is increased by 62%, and the NMN yields of the mutants Nampt-S248A, Nampt-N164L, Nampt-S382M, Nampt-A245T and Nampt-A208G are increased by 34%, 27%, 27%, 22% and 17% respectively.

Abstract: The present disclosure provides an innovative method for improving the enzyme activity of an NMN biosynthetic enzyme Nampt, and relates to the technical field of genetic engineering. A mutant protein of the present disclosure is obtained by firstly analyzing a target protein Nampt using two softwares FoldX and DeepDDG, and then predicting multiple key sites influencing the enzyme functions and finally performing the semi-rational design of the enzyme. In the examples of the present disclosure, 10 mutant strains are constructed using the designed primers according to the principle of point mutation, and 8 of the mutants have higher activity than a wild-type strain, in which the NMN yield of the mutant Nampt-V365L is increased by 62%, and the NMN yields of the mutants Nampt-S248A, Nampt-N164L, Nampt-S382M, Nampt-A245T and Nampt-A208G are increased by 34%, 27%, 27%, 22% and 17% respectively.

Abstract: The present disclosure provides an innovative method for improving the enzyme activity of an NMN biosynthetic enzyme Nampt, and relates to the technical field of genetic engineering. A mutant protein of the present disclosure is obtained by firstly analyzing a target protein Nampt using two softwares FoldX and DeepDDG, and then predicting multiple key sites influencing the enzyme functions and finally performing the semi-rational design of the enzyme. In the examples of the present disclosure, 10 mutant strains are constructed using the designed primers according to the principle of point mutation, and 8 of the mutants have higher activity than a wild-type strain, in which the NMN yield of the mutant Nampt-V365L is increased by 62%, and the NMN yields of the mutants Nampt-S248A, Nampt-N164L, Nampt-S382M, Nampt-A245T and Nampt-A208G are increased by 34%, 27%, 27%, 22% and 17% respectively.