Patents by Inventor Haifan Wu

Haifan Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTI-TARGET CROSSLINKERS AND USES THEREOF
    Publication number: 20220107327
    Abstract: Disclosed herein, inter alia, are compositions and methods for cross-linking biomolecules. In an aspect is provided a method of detecting a covalently conjugated molecule, the method including i) contacting a first biomolecule and a second biomolecule with a crosslinking agent to form a covalently conjugated biomolecule; ii) identifying a first point of attachment of the crosslinking agent to the first biomolecule using mass spectroscopy; and iii) identifying a second point of attachment of the crosslinking agent to the second biomolecule using mass spectroscopy; thereby detecting a covalently conjugated molecule.
    Type: Application
    Filed: October 2, 2019
    Publication date: April 7, 2022
    Inventors: Lei Wang, Bing Yang, Haifan Wu, William DeGrado, Jun Liu
  • Gamma-AApeptides with potent and broad-spectrum antimicrobial activity
    Patent number: 10308686
    Abstract: The present invention is directed to a novel class of antimicrobial agents called ?-AApeptides. The current invention provides various categories of ?-AApeptides, for example, linear ?-AApeptides, cyclic ?-AApeptides, and lipidated ?-AApeptides. ?-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. ?-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed ?-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: June 4, 2019
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jianfeng Cai, Youhong Niu, Haifan Wu, Shruti Padhee
  • GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
    Publication number: 20190100559
    Abstract: The present invention is directed to a novel class of antimicrobial agents called ?-AApeptides. The current invention provides various categories of ?-AApeptides, for example, linear ?-AApeptides, cyclic ?-AApeptides, and lipidated ?-AApeptides. ?-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. ?-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed ?-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
    Type: Application
    Filed: November 30, 2018
    Publication date: April 4, 2019
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: JIANFENG CAI, YOUHONG NIU, HAIFAN WU, SHRUTI PADHEE
  • ?-AApeptides with potent and broad-spectrum antimicrobial activity
    Patent number: 10144764
    Abstract: The present invention is directed to a novel class of antimicrobial agents called ?-AApeptides. The current invention provides various categories of ?-AApeptides, for example, linear ?-AApeptides, cyclic ?-AApeptides, and lipidated ?-AApeptides. ?-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. ?-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed ?-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: December 4, 2018
    Assignee: University of South Florida
    Inventors: Jianfeng Cai, Youhong Niu, Haifan Wu, Shruti Padhee
  • Methods of synthesizing ?-AApeptides, ?-AApeptide building blocks, ?-AApeptide libraries, and ?-AApeptide inhibitors of A?aggregates
    Patent number: 10022420
    Abstract: Embodiments of the present disclosure provide for ?-AApeptides, ?-AApeptide building blocks, methods of making ?-AApeptides and libraries of ?-AApeptides, methods of screening the ?-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for ?-AApeptides that are inhibitors of A? peptide aggregation, methods of inhibiting and disassembling A? peptide aggregation, methods of inhibiting the toxicity of A? aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: July 17, 2018
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jianfeng Cai, Chuanhai Cao, Haifan Wu, Yaqiong Li, Ge Bai
  • METHODS OF SYNTHESIZING GAMMA-AAPEPTIDES, GAMMA-AAPEPTIDE BUILDING BLOCKS, GAMMA-AAPEPTIDE LIBRARIES, AND GAMMA-AAPEPTIDE INHIBITORS OF ALPHA-BETA40 AGGREGATES
    Publication number: 20170232055
    Abstract: Embodiments of the present disclosure provide for ?-AApeptides, ?-AApeptide building blocks, methods of making ?-AApeptides and libraries of ?-AApeptides, methods of screening the ?-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for ?-AApeptides that are inhibitors of A? peptide aggregation, methods of inhibiting and disassembling A? peptide aggregation, methods of inhibiting the toxicity of A? aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.
    Type: Application
    Filed: February 22, 2017
    Publication date: August 17, 2017
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jianfeng Cai, Chuanhai Cao, Haifan Wu, Yaqiong Li, Ge Bai
  • Methods of synthesizing ?-aapeptides, ?-aapeptide building blocks, ?-aapeptide libraries, and ?-aapeptide inhibitors of A?aggregates
    Patent number: 9645155
    Abstract: Embodiments of the present disclosure provide for ?-AApeptides, ?-AApeptide building blocks, methods of making ?-AApeptides and libraries of ?-AApeptides, methods of screening the ?-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for ?-AApeptides that are inhibitors of A? peptide aggregation, methods of inhibiting and disassembling A? peptide aggregation, methods of inhibiting the toxicity of A? aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: May 9, 2017
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jianfeng Cai, Chuanhai Cao, Haifan Wu, Yaqiong Li, Ge Bai
  • GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
    Publication number: 20170058002
    Abstract: The present invention is directed to a novel class of antimicrobial agents called ?-AApeptides. The current invention provides various categories of ?-AApeptides, for example, linear ?-AApeptides, cyclic ?-AApeptides, and lipidated ?-AApeptides. ?-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. ?-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed ?-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
    Type: Application
    Filed: October 13, 2016
    Publication date: March 2, 2017
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: JIANFENG CAI, YOUHONG NIU, HAIFAN WU, SHRUTI PADHEE
  • Gamma-AApeptides with potent and broad-spectrum antimicrobial activity
    Patent number: 9499587
    Abstract: The present invention is directed to a novel class of antimicrobial agents called ?-AApeptides. The current invention provides various categories of ?-AApeptides, for example, linear ?-AApeptides, cyclic ?-AApeptides, and lipidated ?-AApeptides. ?-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. ?-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed ?-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: November 22, 2016
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jianfeng Cai, Youhong Niu, Haifan Wu, Shruti Padhee
  • METHODS OF SYNTHESIZING y-AAPEPTIDES, y-AAPEPTIDE BUILDING BLOCKS, y-AAPEPTIDE LIBRARIES, AND y-AAPEPTIDE INHIBITORS OF Ab40 AGGREGATES
    Publication number: 20160209422
    Abstract: Embodiments of the present disclosure provide for ?-AApeptides, ?-AApeptide building blocks, methods of making ?-AApeptides and libraries of ?-AApeptides, methods of screening the ?-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for ?-AApeptides that are inhibitors of A? peptide aggregation, methods of inhibiting and disassembling A? peptide aggregation, methods of inhibiting the toxicity of A? aggregates towards N2a neuroblasotma cells, as well as methods and compounds for treating Alzheimer's disease.
    Type: Application
    Filed: August 18, 2014
    Publication date: July 21, 2016
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jianfeng CAI, Chuanhai CAO, Haifan WU, Yaqiong LI, Ge BAI
  • GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
    Publication number: 20150274782
    Abstract: The present invention is directed to a novel class of antimicrobial agents called ?-AApeptides. The current invention provides various categories of ?-AApeptides, for example, linear ?-AApeptides, cyclic ?-AApeptides, and lipidated ?-AApeptides. ?-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. ?-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed ?-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
    Type: Application
    Filed: January 23, 2013
    Publication date: October 1, 2015
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jianfeng Cai, Youhong Niu, Haifan Wu, Shruti Padhee