Abstract: The present disclosure relates to the field of display technology, and discloses a display substrate, a preparation method thereof, and a display panel, used for improving the structure of the display substrate, improving characteristics of a thin film transistor, and increasing the yield of a display product. The display substrate includes: a base substrate; a thin film transistor on the base substrate; and a flattening layer on a side, away from the base substrate, of the thin film transistor, wherein the flattening layer is provided with a groove around a channel area of the thin film transistor, and an orthographic projection of the groove on the base substrate is not overlapped with an orthographic projection of the channel area on the base substrate.

Abstract: The present invention provides an optical detection module, a method for manufacturing the same and an optical detection substrate. The optical detection module includes: a base substrate; a switch transistor on a side of the base substrate and including a gate electrode, an active layer, a first electrode and a second electrode; a photosensitive device for sensing light, on a side of the switch transistor away from the base substrate and including a power electrode, a photosensitive layer and an output electrode stacked in sequence, the output electrode being electrically connected to the first electrode of the switch transistor; a barrier on a side of the switch transistor away from the base substrate; and an insulation portion on the same layer as the output electrode and the barrier and connected between the output electrode and the barrier.

Abstract: The present invention provides an optical detection module, a method for manufacturing the same and an optical detection substrate. The optical detection module includes: a base substrate; a switch transistor on a side of the base substrate and including a gate electrode, an active layer, a first electrode and a second electrode; a photosensitive device for sensing light, on a side of the switch transistor away from the base substrate and including a power electrode, a photosensitive layer and an output electrode stacked in sequence, the output electrode being electrically connected to the first electrode of the switch transistor; a barrier on a side of the switch transistor away from the base substrate; and an insulation portion on the same layer as the output electrode and the barrier and connected between the output electrode and the barrier.

Abstract: Provided is a display substrate including: a base substrate, and a light-emitting device and an encapsulating structure which are disposed on the base substrate in sequence in a direction away from the base substrate, wherein the encapsulating structure includes an organic scattering layer and an inorganic barrier layer disposed on at least one side of the organic scattering layer, and the organic scattering layer has bubble structures therein. By arranging an organic scattering layer in the encapsulating structure, the optical coupling efficiency of the display substrate is improved while the encapsulating effect of the encapsulating structure is ensured.

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

Abstract: The present disclosure provides an organic light-emitting diode and a method for manufacturing the same, a display substrate and a method for manufacturing the same, and a display device. The organic light-emitting diode comprises a first electrode, a second electrode, and an organic light-emitting layer arranged between the first electrode and the second electrode, in which the second electrode is arranged close to the light-emitting side of the organic light-emitting diode, the first electrode includes a reflective conductive layer, and a surface of the reflective conductive layer close to the second electrode has an uneven structure.

Abstract: Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

Abstract: The present disclosure provides an organic light-emitting diode and a method for manufacturing the same, a display substrate and a method for manufacturing the same, and a display device. The organic light-emitting diode comprises a first electrode, a second electrode, and an organic light-emitting layer arranged between the first electrode and the second electrode, in which the second electrode is arranged close to the light-emitting side of the organic light-emitting diode, the first electrode includes a reflective conductive layer, and a surface of the reflective conductive layer close to the second electrode has an uneven structure.

Abstract: The present invention discloses an enzyme-linked immunosorbent assay kit for detecting dinitolmide and use thereof. The enzyme-linked immunosorbent assay kit of the present invention comprises dinitolmide antibody and coating antigen and enzyme conjugate; wherein, the dinitolmide antibody is dinitolmide monoclonal antibody or dinitolmide polyclonal antibody; when the coating antigen is the conjugate of dinitolmide hapten and carrier protein, the enzyme conjugate is enzyme-labeled secondary antibody, or enzyme-labeled specific anti-dinitolmide monoclonal or polyclonal antibody; when the coating antigen is dinitolmide antibody or secondary antibody, the enzyme conjugate is enzyme-labeled dinitolmide hapten. The enzyme-linked immunosorbent assay kit has a simple structure, and it is convenient for use, cheap and portable. Its detection is high effective, accurate, and convenient. It can be used for on-site monitoring and is suitable for qualitative and quantitative screenings of a great number of samples.

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

Abstract: The present invention discloses an enzyme-linked immunosorbent assay kit for detecting dinitolmide and use thereof. The enzyme-linked immunosorbent assay kit of the present invention comprises dinitolmide antibody and coating antigen and enzyme conjugate; wherein, the dinitolmide antibody is dinitolmide monoclonal antibody or dinitolmide polyclonal antibody; when the coating antigen is the conjugate of dinitolmide hapten and carrier protein, the enzyme conjugate is enzyme-labeled secondary antibody, or enzyme-labeled specific anti-dinitolmide monoclonal or polyclonal antibody; when the coating antigen is dinitolmide antibody or secondary antibody, the enzyme conjugate is enzyme-labeled dinitolmide hapten. The enzyme-linked immunosorbent assay kit has a simple structure, and it is convenient for use, cheap and portable. Its detection is high effective, accurate, and convenient. It can be used for on-site monitoring and is suitable for qualitative and quantitative screenings of a great number of samples.

Abstract: The present invention discloses an Advertisement Platform (ADP), including an ADP Switch Point (ADP-SP), a voice playing unit and a service logic supporting unit; wherein the ADP-SP connects a call from a calling LS or an MS and initiates an advertisement service call to the service logic supporting unit; upon receiving the advertisement service call from the ADP-SP, the service logic supporting unit returns advertisement service instruction to the ADP-SP after parsing the advertisement service call; upon receiving the advertisement service instruction returned by the service logic supporting unit, the ADP-SP instructs the voice playing unit to play a ring back tone which includes advertisement according to the advertisement service instruction and connects a voice channel used for the voice playing unit playing advertisement with the calling voice channel or the MS voice channel. The present invention also discloses a system and method for playing advertisement.

Abstract: Novel inhibitors of Rho-kinases are disclosed.

Abstract: The present invention discloses an Advertisement Platform (ADP), including an ADP Switch Point (ADP-SP), a voice playing unit and a service logic supporting unit; wherein the ADP-SP connects a call from a calling LS or an MS and initiates an advertisement service call to the service logic supporting unit; upon receiving the advertisement service call from the ADP-SP, the service logic supporting unit returns advertisement service instruction to the ADP-SP after parsing the advertisement service call; upon receiving the advertisement service instruction returned by the service logic supporting unit, the ADP-SP instructs the voice playing unit to play a ring back tone which includes advertisement according to the advertisement service instruction and connects a voice channel used for the voice playing unit playing advertisement with the calling voice channel or the MS voice channel. The present invention also discloses a system and method for playing advertisement.

Abstract: Novel inhibitors of Rho-kinases are disclosed.

Abstract: A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.

Abstract: Novel inhibitors of Rho-kinases are disclosed.

Abstract: A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.