Abstract: A capsule for specific drug delivery and a preparation method therefor, relating to a capsule containing a non-liquid filler and a modified release coating. The modified release coating covers a capsule shell, an isolating layer is provided between the capsule shell and the modified release coating, and no sealing film is provided between the body and cap of the capsule. The capsule can be used for delivering a drug to an intestinal track, and exhibits excellent characteristics in mass production of capsules and drug release.

Abstract: A system and method for real-time transmission of a panoramic video, which propose a new grouping method and bitrate decision method specifically for a panoramic 360-degree video. The grouping method takes into account fields of view of different users, thus effectively reducing the bandwidth consumption of repeated video segments, while ensuring user fairness and making full use of network bandwidth resources when allocating resources. The system and method of the invention can maximize the long-term QoE of users under the condition of limited bandwidth, and avoid the problem that the existing schemes are complex and difficult to meet real-time requirements of users.

Abstract: Disclosed are a method and apparatus for task scheduling based on deep reinforcement learning and a device. The method comprises: obtaining multiple target subtasks to be scheduled; building target state data corresponding to the multiple target subtasks, wherein the target state data comprises a first set, a second set, a third set, and a fourth set; inputting the target state data into a pre-trained task scheduling model, to obtain a scheduling result of each target subtask; wherein, the scheduling result of each target subtask comprises a probability that the target subtask is scheduled to each target node; for each target subtask, determining a target node to which the target subtask is to be scheduled based on the scheduling result of the target subtask, and scheduling the target subtask to the determined target node.

Abstract: The multi-turn dialogue system based on retrieval includes the following modules: a representation module, a matching module, an aggregation module and a prediction module; the multi-turn dialogue method based on retrieval includes the following steps: (1) by a representation module, converting each turn of dialogue into a cascade vector of the dialogue, and converting a candidate answer into a cascade vector of the candidate answer; (2) by a matching module, dynamically absorbing context information based on a global attention mechanism, and calculating a matching vector; (3) by aggregation module, obtaining a short-term dependence information sequence and a long-term dependence information sequence; (4) by a prediction module, calculating the matching score of the context and candidate answer involved in the matching; (5) selecting a candidate answer with the highest matching score as a correct answer.

Abstract: The present invention relates to a pyrazine derivative, an application thereof in inhibiting SHP2, and a compound of formula (I) or pharmaceutically acceptable salts, esters, isomers, solvates, prodrugs or isotope labels thereof. The structure of the compound of formula (I) is as follows. The novel pyrazine derivative provided by the present invention has excellent inhibition of SHP2 activity and can be used to prevent and/or treat non-receptor protein tyrosine phosphatase-mediated or dependent diseases or disorders.

Abstract: A system and method for real-time transmission of a panoramic video, which propose a new grouping method and bitrate decision method specifically for a panoramic 360-degree video. The grouping method takes into account fields of view of different users, thus effectively reducing the bandwidth consumption of repeated video segments, while ensuring user fairness and making full use of network bandwidth resources when allocating resources. The system and method of the invention can maximize the long-term QoE of users under the condition of limited bandwidth, and avoid the problem that the existing schemes are complex and difficult to meet real-time requirements of users.

Abstract: The present invention relates to a pyrazine derivative, an application thereof in inhibiting SHP2, and a compound of formula (I) or pharmaceutically acceptable salts, esters, isomers, solvates, prodrugs or isotope labels thereof. The structure of the compound of formula (I) is as follows. The novel pyrazine derivative provided by the present invention has excellent inhibition of SHP2 activity and can be used to prevent and/or treat non-receptor protein tyrosine phosphatase-mediated or dependent diseases or disorders.

Abstract: A method includes providing a semiconductor body, forming a thermosensitive element on or within the semiconductor body, forming a structured laser-reflective mask on the upper surface of the semiconductor body that covers the thermosensitive element and includes first and second openings, and performing a laser thermal annealing process that transmits laser energy through the first and second openings and into the semiconductor body, wherein the thermosensitive element comprises a critical temperature at which the thermosensitive element is irreparably damaged, wherein the laser thermal annealing process brings portions of the semiconductor body that are underneath the first and second openings to above the critical temperature, and wherein during the laser thermal annealing process the thermosensitive element remains below the critical temperature.

Abstract: A semiconductor body having a base carrier portion and a type III-nitride semiconductor portion is provided. The type III-nitride semiconductor portion includes a heterojunction and two-dimensional charge carrier gas. One or more ohmic contacts are formed in the type III-nitride semiconductor portion, the ohmic contacts forming an ohmic connection with the two-dimensional charge carrier gas. A gate structure is configured to control a conductive state of the two-dimensional charge carrier gas. Forming the one or more ohmic contacts comprises forming a structured laser-reflective mask on the upper surface of the type III-nitride semiconductor portion, implanting dopant atoms into the upper surface of the type III-nitride semiconductor portion, and performing a laser thermal anneal that activates the implanted dopant atoms.

Abstract: A network resource scheduling method, apparatus, an electronic device and a storage medium are disclosed. An embodiment of the method includes: upon receipt of a network data stream, determining a traffic type of the network data stream based on the number of data packets of the network data stream received within a specified period of time, lengths of the data packets and reception times of the data packets; for each data packet comprised in the network data stream, determining a target transmission path for the data packet, based on node state parameters of nodes in the network cluster, link state parameters of links in the network cluster, and the traffic type of the network data stream when the data packet is received; and transmitting the data packet via the target transmission path.

Abstract: The present invention relates to a pyrazine derivative, an application thereof in inhibiting SHP2, and a compound of formula (I) or pharmaceutically acceptable salts, esters, isomers, solvates, prodrugs or isotope labels thereof. The structure of the compound of formula (I) is as follows. The novel pyrazine derivative provided by the present invention has excellent inhibition of SHP2 activity and can be used to prevent and/or treat non-receptor protein tyrosine phosphatase-mediated or dependent diseases or disorders.

Abstract: A semiconductor body having a base carrier portion and a type III-nitride semiconductor portion is provided. The type III-nitride semiconductor portion includes a heterojunction and two-dimensional charge carrier gas. One or more ohmic contacts are formed in the type III-nitride semiconductor portion, the ohmic contacts forming an ohmic connection with the two-dimensional charge carrier gas. A gate structure is configured to control a conductive state of the two-dimensional charge carrier gas. Forming the one or more ohmic contacts comprises forming a structured laser-reflective mask on the upper surface of the type III-nitride semiconductor portion, implanting dopant atoms into the upper surface of the type III-nitride semiconductor portion, and performing a laser thermal anneal that activates the implanted dopant atoms.

Abstract: Disclosed are a method and apparatus for task scheduling based on deep reinforcement learning and a device. The method comprises: obtaining multiple target subtasks to be scheduled; building target state data corresponding to the multiple target subtasks, wherein the target state data comprises a first set, a second set, a third set, and a fourth set; inputting the target state data into a pre-trained task scheduling model, to obtain a scheduling result of each target subtask; wherein, the scheduling result of each target subtask comprises a probability that the target subtask is scheduled to each target node; for each target subtask, determining a target node to which the target subtask is to be scheduled based on the scheduling result of the target subtask, and scheduling the target subtask to the determined target node.

Abstract: A network resource scheduling method, apparatus, an electronic device and a storage medium are disclosed. An embodiment of the method includes: upon receipt of a network data stream, determining a traffic type of the network data stream based on the number of data packets of the network data stream received within a specified period of time, lengths of the data packets and reception times of the data packets; for each data packet comprised in the network data stream, determining a target transmission path for the data packet, based on node state parameters of nodes in the network cluster, link state parameters of links in the network cluster, and the traffic type of the network data stream when the data packet is received; and transmitting the data packet via the target transmission path.

Abstract: Provided are a conjugate of memantine and arctigenin, and a pharmaceutical composition comprising the conjugate. The conjugate can treat diseases associated with A? or Tau protein pathways, such as Alzheimer's disease or Parkinson's disease.

Abstract: Provided are a conjugate of memantine and arctigenin, and a pharmaceutical composition comprising the conjugate. The conjugate can treat diseases associated with A? or Tau protein pathways, such as Alzheimer's disease or Parkinson's disease.

Abstract: The present invention relates to a diarylo[a,g]quinolizidine compound of formula (I), enantiomer, diastereoisomer, racemate, mixture, pharmaceutically acceptable salt, crystalline hydrate or solvate thereof; the preparation method thereof, and uses thereof in preparing an experimental model drugs related to dopamine receptors and 5-HT receptors or a medicament for treating or preventing a disease related to dopamine receptors and 5-HT receptors.

Abstract: Use of hexahydro-dibenzo[a,g]quinolizine compounds as shown in formula(I) in preparing a medicine for treating and/or preventing benign prostate hyperplasia diseases.

Abstract: Use of hexahydro-dibenzo[a,g]quinolizine compounds as shown in formula(I) in preparing a medicine for treating and/or preventing benign prostate hyperplasia diseases.

Abstract: The present invention relates to a novel hexahydrodibenzo[a,g]quinoline compound represented by general formula (I) and its derivatives, enantiomer, diastereoisomer, raceme and mixtures thereof, as well as pharmaceutically acceptable salts thereof. The present invention further relates to a method for preparing the compound, and the compound has good prevention and treatment effect on neurological diseases, especially diseases associated with dopamine receptor and 5-hydroxytryptamine receptor. The bioactivity experiment demonstrates that, the compound is expected to be developed into a novel and potent chemical entity for treating diseases associated with dopamine receptor and 5-hydroxytryptamine receptor, especially schizophrenia, Parkinson's disease, drug addiction, migraine and so on.