Patents by Inventor Haihan Xiao

Haihan Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for modifying amino acid attenuator and use of same in production
    Patent number: 11492616
    Abstract: The present invention discloses a method for modifying an amino acid attenuator, a class of amino acid attenuator mutants, engineered bacteria created on the basis of the amino acid attenuator mutants, and use of the engineered bacteria. The present invention protects a method for relieving the attenuation regulation of an amino acid operon gene, which is modification of the amino acid operon gene by: removing a gene coding for a leader peptide and an anterior reverse complementary palindromic sequence in the terminator stem-loop structure, and maintaining a posterior reverse complementary palindromic sequence in the terminator. The amino acid operon particularly can be histidine operon, tryptophan operon, phenylalanine operon, alanine operon, threonine operon and etc. The present invention can be used for the production of amino acids and derivatives thereof in fermentation by bacteria, providing a novel method for improving the production of amino acids in fermentation.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: November 8, 2022
    Assignee: Institute of Microbiology, Chinese Academy of Sciences
    Inventors: Tingyi Wen, Shuwen Liu, Yun Zhang, Xiuling Shang, Haihan Xiao
  • METHOD FOR MODIFYING AMINO ACID ATTENUATOR AND USE OF SAME IN PRODUCTION
    Publication number: 20190338282
    Abstract: The present invention discloses a method for modifying an amino acid attenuator, a class of amino acid attenuator mutants, engineered bacteria created on the basis of the amino acid attenuator mutants, and use of the engineered bacteria. The present invention protects a method for relieving the attenuation regulation of an amino acid operon gene, which is modification of the amino acid operon gene by: removing a gene coding for a leader peptide and an anterior reverse complementary palindromic sequence in the terminator stem-loop structure, and maintaining a posterior reverse complementary palindromic sequence in the terminator. The amino acid operon particularly can be histidine operon, tryptophan operon, phenylalanine operon, alanine operon, threonine operon and etc.
    Type: Application
    Filed: October 24, 2017
    Publication date: November 7, 2019
    Inventors: Tingyi Wen, Shuwen Liu, Yun Zhang, Xiuling Shang, Haihan Xiao