Abstract: The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Abstract: The present disclosure relates to an electromagnetic stamping method and an electromagnetic stamping device. The electromagnetic stamping method includes: dividing a blank holder of a stamping device into a plurality of blank holder areas based on a contour characteristic of a workpiece to be stamped; setting a blank holder force function over time for each blank holder area based on a shape characteristic of the blank holder area; collecting blank holder force data of each blank holder area every cycle period t0, and calculating an error between the blank holder force data and a value of the blank holder force function at a current time; and controlling a blank holder force for each blank holder area based on the error, and obtaining the workpiece to be stamped by stamping sheet material under the blank holder force.

Abstract: Disclosed are an energy service system of a multi-machine production line and a control method thereof, the method includes reorganizing respective machines in the production line into three types of controllable entities: a drive system, an energy supply bus and an execution device, equipping them with a control center, and selecting a sub-drive system that is idle and is capable of completing the work stage with high energy efficiency to supply energy service for the corresponding execution device through the energy supply bus. Further disclosed is a design method of a multi-machine shared drive system of a production line, which increases the number of basic flow units of each drive unit to a maximum value one by one, and coordinates action time to form a variety of scheduling schemes, and selects a configuration scheme whose total time and total energy consumption are less as the shared drive system.

Abstract: The present disclosure relates to an electromagnetic stamping method and an electromagnetic stamping device. The electromagnetic stamping method includes: dividing a blank holder of a stamping device into a plurality of blank holder areas based on a contour characteristic of a workpiece to be stamped; setting a blank holder force function over time for each blank holder area based on a shape characteristic of the blank holder area; collecting blank holder force data of each blank holder area every cycle period t0, and calculating an error between the blank holder force data and a value of the blank holder force function at a current time; and controlling a blank holder force for each blank holder area based on the error, and obtaining the workpiece to be stamped by stamping sheet material under the blank holder force.

Abstract: A press machine is provided. Two vertical hydraulic cylinders are arranged on an upper beam plate of a press machine body, and the two hydraulic cylinders correspond to workbenches at corresponding positions in a one-to-one correspondence, constituting left and right working units, and a common mechanical drive unit and a common hydraulic drive unit are set for the left and right working units. The mechanical driving unit is composed of a driving motor through an electromagnetic clutch, an electromagnetic brake and lead screw nut driving mechanism driven by a gear pair. According to the load profiles during the working process of hydraulic press machine, the mechanical driving unit or the hydraulic driving unit are selected to provide energy for the two working units. A control method for the press machine, a press machine execution system and a control method for the press machine execution system are further involved.

Abstract: A device and a method for fabricating a ceramic reinforced composite coating based on plasma remelting and injection. The device includes a plasma cladding assembly, a powder feeding assembly, a metal-based substrate, and a thermal infrared imager. The plasma cladding assembly comprises a plasma gun and a plasma generator. A plasma arc generated is used to heat the substrate and form a molten pool on the substrate. The powder feeding assembly comprises a powder feeder configured to feed ceramic particles to the molten pool through a powder feeding copper tube. The thermal infrared imager is configured to acquire an infrared image of the molten pool and acquire an optimal injection position of the ceramic particles according to the infrared image. The optimal injection position is a midpoint between a trailing edge of the plasma arc emitted on the substrate and a trailing edge of the molten pool.

Abstract: The present invention discloses a nitrogen-containing heterocyclic substituted benzoxazine oxazolidinone compound, a preparation method and use thereof in the manufacture of a medicament for treating and/or preventing infectious diseases caused by Mycobacterium tuberculosis. Specifically, the present invention relates to a compound represented by formula (I) and stereoisomer thereof, pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the compounds of the present invention, use thereof, a method for preparing the compound, in which X1, X2, R1 and R2 are described in the specification.

Abstract: A press machine is provided. Two vertical hydraulic cylinders are arranged on an upper beam plate of a press machine body, and the two hydraulic cylinders correspond to workbenches at corresponding positions in a one-to-one correspondence, constituting left and right working units, and a common mechanical drive unit and a common hydraulic drive unit are set for the left and right working units. The mechanical driving unit is composed of a driving motor through an electromagnetic clutch, an electromagnetic brake and lead screw nut driving mechanism driven by a gear pair. According to the load profiles during the working process of hydraulic press machine, the mechanical driving unit or the hydraulic driving unit are selected to provide energy for the two working units. A control method for the press machine, a press machine execution system and a control method for the press machine execution system are further involved.

Abstract: Disclosed is a double-motor double-station screw press, comprising two sets of screw pair mechanisms on both sides thereof, i.e., first and second screw pair mechanisms, where in the first screw pair mechanism, a first lead screw is driven by a resultant movement synthesized by first and second motors through a first differential gear train; in the second screw pair mechanism, a second lead screw is driven by a resultant movement synthesized by the first and second motors through a second differential gear train; a first slider and a second slider in the press work symmetrically; a transmission mode between the second motor and the second differential gear train is switched by controlling a steering switching apparatus, such that the second motor can assist the first motor during a single-cylinder pressing process to increase the output pressure, but also it is convenient to adjust a relative positions of two cylinders.

Abstract: A press machine is provided. Two vertical hydraulic cylinders are arranged on an upper beam plate of a press machine body, and the two hydraulic cylinders correspond to workbenches at corresponding positions in a one-to-one correspondence, constituting left and right working units, and a common mechanical drive unit and a common hydraulic drive unit are set for the left and right working units. The mechanical driving unit is composed of a driving motor through an electromagnetic clutch, an electromagnetic brake and lead screw nut driving mechanism driven by a gear pair. According to the load profiles during the working process of hydraulic press machine, the mechanical driving unit or the hydraulic driving unit are selected to provide energy for the two working units. A control method for the press machine, a press machine execution system and a control method for the press machine execution system are further involved.

Abstract: Disclosed are an energy service system of a multi-machine production line and a control method thereof, the method includes reorganizing respective machines in the production line into three types of controllable entities: a drive system, an energy supply bus and an execution device, equipping them with a control center, and selecting a sub-drive system that is idle and is capable of completing the work stage with high energy efficiency to supply energy service for the corresponding execution device through the energy supply bus. Further disclosed is a design method of a multi-machine shared drive system of a production line, which increases the number of basic flow units of each drive unit to a maximum value one by one, and coordinates action time to form a variety of scheduling schemes, and selects a configuration scheme whose total time and total energy consumption are less as the shared drive system.

Abstract: The present invention discloses a nitrogen-containing heterocyclic substituted benzoxazine oxazolidinone compound, a preparation method and use thereof in the manufacture of a medicament for treating and/or preventing infectious diseases caused by Mycobacterium tuberculosis. Specifically, the present invention relates to a compound represented by formula (I) and stereoisomer thereof, pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the compounds of the present invention, use thereof, a method for preparing the compound, in which X1, X2, R1 and R2 are described in the specification.

Abstract: Disclosed is a double-motor double-station screw press, comprising two sets of screw pair mechanisms on both sides thereof, i.e., first and second screw pair mechanisms, where in the first screw pair mechanism, a first lead screw is driven by a resultant movement synthesized by first and second motors through a first differential gear train; in the second screw pair mechanism, a second lead screw is driven by a resultant movement synthesized by the first and second motors through a second differential gear train; a first slider and a second slider in the press work symmetrically; a transmission mode between the second motor and the second differential gear train is switched by controlling a steering switching apparatus, such that the second motor can assist the first motor during a single-cylinder pressing process to increase the output pressure, but also it is convenient to adjust a relative positions of two cylinders.

Abstract: The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Abstract: The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Abstract: A press machine is provided. Two vertical hydraulic cylinders are arranged on an upper beam plate of a press machine body, and the two hydraulic cylinders correspond to workbenches at corresponding positions in a one-to-one correspondence, constituting left and right working units, and a common mechanical drive unit and a common hydraulic drive unit are set for the left and right working units. The mechanical driving unit is composed of a driving motor through an electromagnetic clutch, an electromagnetic brake and lead screw nut driving mechanism driven by a gear pair. According to the load profiles during the working process of hydraulic press machine, the mechanical driving unit or the hydraulic driving unit are selected to provide energy for the two working units. A control method for the press machine, a press machine execution system and a control method for the press machine execution system are further involved.

Abstract: The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Abstract: The present invention relates to compounds of Formula VIII with absolute configuration R or S: as well as pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein the variables are described herein. The present invention further relates to pharmaceutical compositions which comprise the compounds of Formula VIII, and to methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation.

Abstract: The present invention relates to compounds of Formula VIII with absolute configuration R or S: as well as pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein the variables are described herein. The present invention further relates to pharmaceutical compositions which comprise the compounds of Formula VIII, and to methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation.

Abstract: The present invention relates to compounds of Formula I: as well as pharmaceutically acceptable salts, hydrates, isomers, or solvates thereof, wherein the variables are described herein. The present invention further relates to pharmaceutical compositions which comprise the compounds of Formula I, and to methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation.