Patents by Inventor Haihong Jin

Haihong Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULES PROMOTING SYMPATHETIC NERVE REGENERATION
    Publication number: 20230373907
    Abstract: The present invention concerns novel compounds, pharmaceutical compositions, and methods for promoting nerve regeneration, particularly including sympathetic nerve regeneration in the heart following a myocardial infarction and damage to the central nervous system, such as after a cerebrovascular accident, through inhibitory extracellular matrix that includes chondroitin sulfate roteoglycans (CSPG).
    Type: Application
    Filed: August 30, 2021
    Publication date: November 23, 2023
    Inventors: Michael Cohen, Beth Habecker, Haihong Jin, Ryan Gardner
  • Compounds and methods used in assessing mono-PARP activity
    Patent number: 11530235
    Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: December 20, 2022
    Assignee: Oregon Health & Science University
    Inventors: Michael Cohen, Ian Carter-O'Connell, Rory Morgan, Haihong Jin
  • SMALL MOLECULE ACTIVATORS OF INTERFERON REGULATORY FACTOR 3 AND METHODS OF USE THEREOF
    Publication number: 20220395500
    Abstract: Small molecule activators of interferon regulatory factor (IRF), such as IRF3, and methods of use are provided. In particular, compositions and methods for upregulating interferon regulatory factor 3 (IRF3) activity, such as in the brain following stroke to provide potent protection against ischemic brain injury, to improve a therapeutic time window for providing treatments to stroke patients and/or for enhancement of vaccine platforms are disclosed.
    Type: Application
    Filed: May 4, 2021
    Publication date: December 15, 2022
    Inventors: Susan Stevens, Mary Stenzel-Poore, Marie Foss, Aaron Nilsen, Haihong Jin
  • COMPOUNDS AND METHODS USED IN ASSESSING MONO-PARP ACTIVITY
    Publication number: 20200123192
    Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.
    Type: Application
    Filed: December 16, 2019
    Publication date: April 23, 2020
    Applicant: Oregon Health & Science University
    Inventors: Michael Cohen, Ian Carter-O'Connell, Rory Morgan, Haihong Jin
  • Small molecules that bind MR1
    Patent number: 10457682
    Abstract: Disclosed are small molecules and pharmaceutical compositions comprising them that can be used in treating diseases associated with the major histocompatibility complex (MHC) molecule MR1.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: October 29, 2019
    Inventors: David Lewinsohn, Melanie Harriff, Aaron Nilsen, Haihong Jin, Erin Adams, Cara Froyd, Curtis McMurtrey, William Hildebrand
  • SMALL MOLECULES THAT BIND MR1
    Publication number: 20180273536
    Abstract: Disclosed are small molecules and pharmaceutical compositions comprising them that can be used in treating diseases associated with the major histocompatibility complex (MHC) molecule MR1.
    Type: Application
    Filed: October 20, 2017
    Publication date: September 27, 2018
    Applicants: OREGON HEALTH & SCIENCE UNIVERSITY, HE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: David Lewinsohn, Melanie Harriff, Aaron Nilsen, Haihong Jin, Erin Adams, Cara Froyd, Curtis McMurtrey, William Hildebrand
  • COMPOUNDS AND METHODS USED IN ASSESSING MONO-PARP ACTIVITY
    Publication number: 20170146517
    Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.
    Type: Application
    Filed: November 18, 2016
    Publication date: May 25, 2017
    Applicant: OREGON HEALTH AND SCIENCE UNIVERSITY
    Inventors: Michael Cohen, Ian Carter-O'Connell, Rory Morgan, Haihong Jin
  • CELL SPECIFIC LABELING OF NEWLY SYNTHESIZED PROTEINS
    Publication number: 20160176919
    Abstract: Disclosed herein are compositions comprising blocked puromycin analogs that are converted into active puromycin analogs upon the activity of a penicillin acylase. Also disclosed are methods of using blocked puromycin analogs to label proteins in a selected cell type in vivo in a transgenic multicellular organism that expresses a penicillin acylase within the selected cell type. Also disclosed are transgenic mice expressing a penicillin acylase within a selected cell type.
    Type: Application
    Filed: December 22, 2015
    Publication date: June 23, 2016
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Michael Cohen, Ruth Barrett, Haihong Jin
  • 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
    Patent number: 8772482
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: July 8, 2014
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Tryptophan hydroxylase inhibitors
    Patent number: 8629156
    Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: January 14, 2014
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Qingyun Liu, Brett Marinelli, Lakshama Samala, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Wenxue Wu, Chengmin Zhang, Haiming Zhang
  • TRYPTOPHAN HYDROXYLASE INHIBITORS
    Publication number: 20120157484
    Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
    Type: Application
    Filed: November 7, 2011
    Publication date: June 21, 2012
    Inventors: Arokiasamy DEVASAGAYARAJ, Haihong Jin, Qingyun Liu, Brett Marinelli, Lakshama Samala, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Wenxue Wu, Chengmin Zhang, Haiming Zhang
  • 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds and Methods of Their Use
    Publication number: 20120041008
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Application
    Filed: June 17, 2011
    Publication date: February 16, 2012
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Multicyclic amino acid derivatives and methods of their use
    Patent number: 8063057
    Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: November 22, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Brett Marinelli, Lakshama Samala, Zhi Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds
    Patent number: 7968559
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: June 28, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Methods of using 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds
    Publication number: 20100311764
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Application
    Filed: April 5, 2010
    Publication date: December 9, 2010
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE
    Publication number: 20100280054
    Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
    Type: Application
    Filed: March 30, 2010
    Publication date: November 4, 2010
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Qingyun Liu, Brett Marinelli, Lakshama Samala, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Wenxue Wu, Chengmin Zhang, Haiming Zhang
  • Multicyclic amino acid derivatives and methods of their use
    Patent number: 7723345
    Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: May 25, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Brett Marinelli, Lakshama Samala, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
    Patent number: 7709493
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: May 4, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Methods of inhibiting tryptophan hydroxylase
    Publication number: 20100087433
    Abstract: Compounds, compositions and methods of treating serotonin-mediated diseases and disorders are disclosed.
    Type: Application
    Filed: October 1, 2009
    Publication date: April 8, 2010
    Inventors: Catherine Bomont, Arokiasamy Devasagayaraj, Haihong Jin, Brett Marinelli, Lakshama Samala, Zhi-Cai Shi, Ashok Tunoori, Ying Wang
  • 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds and Methods of Their Use
    Publication number: 20090286817
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Application
    Filed: May 20, 2009
    Publication date: November 19, 2009
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang