Patents by Inventor Haihong Li
Haihong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082415Abstract: This disclosure relates to antibody-drug conjugates (ADCs) comprising an anti-Trop-2 antibody. Provided herein are compositions comprising such ADCs, as well as methods of making and using the same.Type: ApplicationFiled: November 2, 2022Publication date: March 14, 2024Applicants: Levena (Suzhou) Biopharma Co., Ltd., Shanghai Escugen Biotechnology Co., Ltd.Inventors: Tong Zhu, Alisher B. Khasanov, Hui Li, Maojun Guo, Haihong Li, Chuanying Xu, Feng He, Qing Zhou
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Publication number: 20220135613Abstract: The disclosure provides a method for preparing drug toxin PNU-159682 (morpholinyl anthracycline derivative) for antibody-conjugated drugs and intermediates involved in the preparation method. The preparation method of the present disclosure improves the stability, practicability and scalability of the process by introducing protecting groups and changing to reagents that are capable to amplify; the preparation method of the present disclosure minimizes the risk and operational difficulty during scale-up production; production and operation is simple and convenient.Type: ApplicationFiled: April 24, 2020Publication date: May 5, 2022Inventors: Lingpei KONG, Zhongquan JIA, Binbin ZHANG, YU CHEN, Deyin XIA, DONG GUI, Haihong LI, Maojun GUO, HUI LI
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Publication number: 20220119441Abstract: The disclosure provides a method for preparing drug-linker MC-MMAF for antibody drug conjugates and intermediates therein. The preparation method of the present disclosure improves the reactivity of the N-terminal, thereby effectively controlling the occurrence of racemization; does not directly use the toxin MMAF, but uses fragmented peptides with lower toxicity, which minimizes the operational difficulty in scale-up production; no reverse phase is required and it is easy to prepare and operate.Type: ApplicationFiled: June 26, 2019Publication date: April 21, 2022Inventors: Zhe Xu, Haihong Li, Maojun Guo, Hui Li
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Patent number: 11166746Abstract: The present invention relates to an integrated device for hair follicle extraction and implanting, comprising a body mechanism and a connecting mechanism, the body mechanism comprising a body supporting frame, a first motor, a transmission frame, a second motor, a clamping component, a transmission mechanism and a pushing needle, the connecting mechanism comprises a connecting head, a fixing head and a cutter head, wherein the first motor of the body mechanism controls the up and down movement of the cutter head through the cooperation of the transmission frame and the transmission mechanism, and the second motor controls the pushing needle by the rotary motion of the clamping unit, simultaneously controls the rotational movement of the cutter head through the transmission mechanism. Compared with the prior art, the invention realizes the integrated operation of hair follicle extracting and implanting, and makes the operation of hair follicle implanting more convenient.Type: GrantFiled: April 24, 2019Date of Patent: November 9, 2021Assignee: Shantou UniversityInventors: Changmin Lin, Shaoke Chen, Keng Huang, Haihong Li, Hanmin Huo, Junwei Huang, Cheng Yang, Zhuoying Yu, Zhiwen Chen, Lingli Kong, Haibin Chen, Shaoqin You, Haixia Ma, Zhenping Li, Xiaoyun Zhang, Xin Chen
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Publication number: 20190247089Abstract: The present invention relates to an integrated device for hair follicle extraction and implanting, comprising a body mechanism and a connecting mechanism, the body mechanism comprising a body supporting frame, a first motor, a transmission frame, a second motor, a clamping component, a transmission mechanism and a pushing needle, the connecting mechanism comprises a connecting head, a fixing head and a cutter head, wherein the first motor of the body mechanism controls the up and down movement of the cutter head through the cooperation of the transmission frame and the transmission mechanism, and the second motor controls the pushing needle by the rotary motion of the clamping unit, simultaneously controls the rotational movement of the cutter head through the transmission mechanism. Compared with the prior art, the invention realizes the integrated operation of hair follicle extracting and implanting, and makes the operation of hair follicle implanting more convenient.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Inventors: Changmin Lin, Shaoke Chen, Keng Huang, Haihong Li, Hanmin Huo, Junwei Huang, Cheng Yang, Zhuoying Yu, Zhiwen Chen, Lingli Kong, Haibin Chen, Shaoqin You, Haixia Ma, Zhenping Li, Xiaoyun Zhang, Xin Chen
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Publication number: 20180021700Abstract: Described herein is combination of flocculants for flocculating fines solids in a suspension thereof. The combination includes: (a) an anionic polymer flocculant, and (b) a charged particle-polymer hybrid flocculant that includes charged core particles having an average size between about 150 nm and about 800 nm and each having a polymer polymerized thereon. The anionic polymer flocculant is to be added before, or at substantially the same time as, the charged particle-polymer hybrid flocculant.Type: ApplicationFiled: October 4, 2017Publication date: January 25, 2018Inventors: Haihong LI, Zhiang (Joe) ZHOU, Ross CHOW, Xinghua MO, Harold Bernard KRENKEL
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Publication number: 20160214037Abstract: Described herein is combination of flocculants for flocculating fines solids in a suspension thereof. The combination includes: (a) an anionic polymer flocculant, and (b) a charged particle-polymer hybrid flocculant that includes charged core particles having an average size between about 150 nm and about 800 nm and each having a polymer polymerized thereon. The anionic polymer flocculant is to be added before, or at substantially the same time as, the charged particle-polymer hybrid flocculant.Type: ApplicationFiled: April 6, 2016Publication date: July 28, 2016Inventors: Haihong LI, Zhiang (Joe) ZHOU, Ross CHOW, Xinghua MO, Harold Bernard KRENKEL
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Publication number: 20150266991Abstract: Described herein is a charged particle-polymer hybrid flocculant that includes charged particles having an average size between about 150 nm and about 800 nm and each having a polymer polymerized thereon. Charged particle-polymer hybrid flocculants are made by forming charged particles having an average size between about 150 nm and about 800 nm; and polymerizing a monomer on the charged particles to form the polymer. Fine solids are separated from a suspension thereof by adding the charged particle polymer hybrid to the suspension to produce floccules and a supernatant, and separating the produced floccules from the supernatant.Type: ApplicationFiled: March 19, 2015Publication date: September 24, 2015Inventors: Haihong LI, Zhiang (Joe) ZHOU, Ross Chow
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Patent number: 8915374Abstract: This invention relates to particulate and/or liquid droplet separation processes from liquids containing the same and the use of specific chemical additives to control surface wetting, hydrophobicity and surface forces in such processes.Type: GrantFiled: September 19, 2008Date of Patent: December 23, 2014Assignee: The University of MelbourneInventors: George Vincent Franks, Haihong Li
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Patent number: 8481741Abstract: The present invention relates to a method for preparing 6-substituted amino-3-cyanoquinoline compounds (compound A for short) and the intermediates thereof, more particularly, to a compound of the following formula (I), the preparation method thereof, the intermediates thereof and use thereof for preparing the compound A. The compound of the formula (I) is cyclized in the presence of an alkali to give a compound of formula A, wherein W is OH; or the compound of the formula (I) is cyclized in the presence of an alkali, and then chlorinated to give a compound of the formula A, wherein W is Cl. Compared with the known methods in the literature, the method for preparing the compound A from the compound of formula (I) according to the present invention can avoid using high-temperature condition and high boiling point solvents, and is safe and environment-friendly, mild in reaction condition, easy in operation with a high yield and high product purity.Type: GrantFiled: October 23, 2009Date of Patent: July 9, 2013Assignees: Topharman Shanghai Co., Ltd., Shanghai Institute of Materia Medica, Chinese Academy of SciencesInventors: Yongjun Mao, Jianfeng Li, Jin Zheng, Zheng Liu, Kai Xie, Haihong Li, Jing Shi, Ye Li, Jingshan Shen
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Patent number: 8242264Abstract: The present invention relates to a process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof. The present invention provides a compound represented by formula I and a compound represented by formula II, and processes for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine by using the compound represented by formula I, the compound represented by formula II and o-nitrobenzaldehyde. The invention has the advantages of the shorter synthesis steps, easily available raw materials and simple operation. Moreover, the process is economic and safe by avoiding the use of expensive and dangerous lithium aluminum hydride.Type: GrantFiled: May 22, 2008Date of Patent: August 14, 2012Assignees: Topharman Shanghai Co., Ltd., Weifang Tehua Chemical Co., Ltd.Inventors: Fuqiang Zhu, Haihong Li, Wenzhong Wang, Hui Zhang, Jingshan Shen
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Publication number: 20120138543Abstract: A charged particle polymer hybrid (CPPH) flocculant is taught, comprising sub-micron size charged particles and a polymer which has been polymerized in the presence of the charged particles wherein the intrinsic viscosity of the hybrid polymer flocculant is less than 930 ml/g. A method is provided for producing freely draining flocculated sediment from a suspension comprising finely divided solids in water. The method comprises dispersing, at increasing concentrations, a charged particle polymer hybrid (CPPH) flocculant into the suspension to determine a starting plateau concentration of CPPH flocculant above which concentration no further increase in the solids loading of the produced floccules is observed. Then, the concentration of dispersed CPPH flocculant in the suspension is maintained at or above the starting plateau concentration. A method is further provided for separating fine solids and water from a suspension comprising finely divided solids in water.Type: ApplicationFiled: June 2, 2011Publication date: June 7, 2012Applicant: ALBERTA INNOVATES - TECHNOLOGY FUTURESInventors: Haihong LI, Zhiang ZHOU, Ross Sam CHOW, Pablo CONTRERAS
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Publication number: 20110263860Abstract: The present invention relates to a method for preparing 6-substituted amino-3-cyanoquinoline compounds (compound A for short) and the intermediates thereof, more particularly, to a compound of the following formula (I), the preparation method thereof, the intermediates thereof and use thereof for preparing the compound A. The compound of the formula (I) is cyclized in the presence of an alkali to give a compound of formula A, wherein W is OH; or the compound of the formula (I) is cyclized in the presence of an alkali, and then chlorinated to give a compound of the formula A, wherein W is Cl. Compared with the known methods in the literature, the method for preparing the compound A from the compound of formula (I) according to the present invention can avoid using high-temperature condition and high boiling point solvents, and is safe and environment-friendly, mild in reaction condition, easy in operation with a high yield and high product purity.Type: ApplicationFiled: October 23, 2009Publication date: October 27, 2011Applicants: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Topharman Shangai Co., Ltd.Inventors: Yongjun Mao, Jianfeng Li, Jin Zheng, Zheng Liu, Kai Xie, Haihong Li, Jing Shi, Ye Li, Jingshan Shen
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Publication number: 20110135797Abstract: A method is taught for producing freely draining flocculated sediment from a suspension comprising finely divided solids in water. The method comprises dispersing, at increasing concentrations, a charged particle hybrid polymer (CPHP) flocculant into the suspension to determine a minimum concentration of CPHP flocculant above which a freely draining flocculated sediment is produced that has a minimum permeability of 1 Darcy. Then, the concentration of dispersed CPHP flocculant in the suspension is maintained at or above the minimum concentration. A method is further provided for separating fine solids and water from a suspension comprising finely divided solids in water. The method involves dispersing, at increasing concentrations, a charged particle hybrid polymer (CPHP) flocculant into the suspension to determine a minimum concentration of CPHP flocculant above which a freely draining flocculated sediment is produced that has a minimum permeability of 1 Darcy.Type: ApplicationFiled: August 18, 2010Publication date: June 9, 2011Applicant: ALBERTA INNOVATES - TECHNOLOGY FUTURESInventors: Haihong LI, Zhiang ZHOU, Ross Sam CHOW, Pablo CONTRERAS
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Publication number: 20110017676Abstract: This invention relates to particulate and/or liquid droplet separation processes from liquids containing the same and the use of specific chemical additives to control surface wetting, hydrophobicity and surface forces in such processes.Type: ApplicationFiled: September 19, 2008Publication date: January 27, 2011Applicant: The University of MelbourneInventors: George Vincent Franks, Haihong Li
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Publication number: 20100256358Abstract: The present invention relates to a process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof. The present invention provides a compound represented by formula I and a compound represented by formula II, and processes for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine by using the compound represented by formula I, the compound represented by formula II and o-nitrobenzaldehyde. The invention has the advantages of the shorter synthesis steps, easily available raw materials and simple operation. Moreover, the process is economic and safe by avoiding the use of expensive and dangerous lithium aluminum hydride.Type: ApplicationFiled: May 22, 2008Publication date: October 7, 2010Applicants: TOPHARMAN SHANGHAI CO., LTD., WEIFANG TEHUA CHEMICAL CO., LTD.Inventors: Fuqiang Zhu, Haihong Li, Wenzhong Wang, Hui Zhang, Jingshan Shen
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Publication number: 20050194292Abstract: A method of improving hydrocarbon recovery from oil sands, oil shale, and petroleum residues includes adding a polymeric or nonpolymeric processing aid capable of sequestering cations, such as the multivalent calcium, magnesium and iron cations. The hydrocarbons are preferably contacted with the processing aid before a primary separation of the hydrocarbons in order to increase bitumen recovery. A processing aid is provided in an effective amount to increase the liberation of the hydrocarbons from inorganic solids, particularly when the source is a poor processing ore. Preferred processing aids include citric acid or a polymeric acid selected from polyacrylic acid, polymethacrylic acid, salts of these acids, partial salts of these acids, and combinations thereof. The processing aids significantly increase the hydrocarbon recovery typically with concentrations less than 50 ppm and the polymeric processing aids can also provide beneficial flocculation of solids in tailings slurry.Type: ApplicationFiled: September 22, 2004Publication date: September 8, 2005Inventors: Jan Beetge, Tshitende Kasongo, Bradley Komishke, Haihong Li, Jun Long, Jacob Masliyah, Petrus Venter, Sanyi Wang, Zhenghe Xu
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Patent number: D619934Type: GrantFiled: December 28, 2009Date of Patent: July 20, 2010Assignee: Kaikai Meiduo Motorcycle Co., Ltd.Inventor: Haihong Li