Abstract: A method and a system for constructing a soil water movement model based on the physical information neural networks are provided. The soil water movement model is constructed by fusing the physical information neural network and a control equation of the soil water movement model, and the model adopts automatic differentiation to replace difference operation of grid scale, so that the calculation error caused by equation discretization in the solving process of numerical differentiation is avoided, and the calculation accuracy is improved; and the automatic differentiation mode is mainly carried out aiming at the output of a neural network, so that the numerical value of gradient calculation is more accurate.

Abstract: A high-efficiency solar multi-layer evaporative seawater desalination device includes a transparent housing. In the device, wedge-shaped recesses are formed on an outer wall of the transparent housing; during seawater desalination, seawater is injected into evaporation trays and sunlight is irradiated on the evaporation trays through the transparent housing; the transparent housing is made of a transparent plastic material, such that sunlight can directly enter the transparent housing and increase a temperature therein to speed up the evaporation; the wedge-shaped recesses are on a shady surface; during desalination, seawater in the evaporation trays absorbs heat and evaporates to form water vapor, such that there is a given temperature difference between the water vapor and the outside; and a lower part of the wedge-shaped recess can serve as a condensation surface, the water vapor condenses on the transparent housing or at the wedge-shaped recess.

Abstract: A high-efficiency solar multi-layer evaporative seawater desalination device includes a transparent housing. In the device, wedge-shaped recesses are formed on an outer wall of the transparent housing; during seawater desalination, seawater is injected into evaporation trays and sunlight is irradiated on the evaporation trays through the transparent housing; the transparent housing is made of a transparent plastic material, such that sunlight can directly enter the transparent housing and increase a temperature therein to speed up the evaporation; the wedge-shaped recesses are on a shady surface; during desalination, seawater in the evaporation trays absorbs heat and evaporates to form water vapor, such that there is a given temperature difference between the water vapor and the outside; and a lower part of the wedge-shaped recess can serve as a condensation surface, the water vapor condenses on the transparent housing or at the wedge-shaped recess.

Abstract: This disclosure relates to antibody-drug conjugates (ADCs) comprising an anti-Trop-2 antibody. Provided herein are compositions comprising such ADCs, as well as methods of making and using the same.

Abstract: The disclosure provides a method for preparing drug toxin PNU-159682 (morpholinyl anthracycline derivative) for antibody-conjugated drugs and intermediates involved in the preparation method. The preparation method of the present disclosure improves the stability, practicability and scalability of the process by introducing protecting groups and changing to reagents that are capable to amplify; the preparation method of the present disclosure minimizes the risk and operational difficulty during scale-up production; production and operation is simple and convenient.

Abstract: The disclosure provides a method for preparing drug-linker MC-MMAF for antibody drug conjugates and intermediates therein. The preparation method of the present disclosure improves the reactivity of the N-terminal, thereby effectively controlling the occurrence of racemization; does not directly use the toxin MMAF, but uses fragmented peptides with lower toxicity, which minimizes the operational difficulty in scale-up production; no reverse phase is required and it is easy to prepare and operate.

Abstract: The present invention relates to an integrated device for hair follicle extraction and implanting, comprising a body mechanism and a connecting mechanism, the body mechanism comprising a body supporting frame, a first motor, a transmission frame, a second motor, a clamping component, a transmission mechanism and a pushing needle, the connecting mechanism comprises a connecting head, a fixing head and a cutter head, wherein the first motor of the body mechanism controls the up and down movement of the cutter head through the cooperation of the transmission frame and the transmission mechanism, and the second motor controls the pushing needle by the rotary motion of the clamping unit, simultaneously controls the rotational movement of the cutter head through the transmission mechanism. Compared with the prior art, the invention realizes the integrated operation of hair follicle extracting and implanting, and makes the operation of hair follicle implanting more convenient.

Abstract: The present invention relates to an integrated device for hair follicle extraction and implanting, comprising a body mechanism and a connecting mechanism, the body mechanism comprising a body supporting frame, a first motor, a transmission frame, a second motor, a clamping component, a transmission mechanism and a pushing needle, the connecting mechanism comprises a connecting head, a fixing head and a cutter head, wherein the first motor of the body mechanism controls the up and down movement of the cutter head through the cooperation of the transmission frame and the transmission mechanism, and the second motor controls the pushing needle by the rotary motion of the clamping unit, simultaneously controls the rotational movement of the cutter head through the transmission mechanism. Compared with the prior art, the invention realizes the integrated operation of hair follicle extracting and implanting, and makes the operation of hair follicle implanting more convenient.

Abstract: Described herein is combination of flocculants for flocculating fines solids in a suspension thereof. The combination includes: (a) an anionic polymer flocculant, and (b) a charged particle-polymer hybrid flocculant that includes charged core particles having an average size between about 150 nm and about 800 nm and each having a polymer polymerized thereon. The anionic polymer flocculant is to be added before, or at substantially the same time as, the charged particle-polymer hybrid flocculant.

Abstract: Described herein is combination of flocculants for flocculating fines solids in a suspension thereof. The combination includes: (a) an anionic polymer flocculant, and (b) a charged particle-polymer hybrid flocculant that includes charged core particles having an average size between about 150 nm and about 800 nm and each having a polymer polymerized thereon. The anionic polymer flocculant is to be added before, or at substantially the same time as, the charged particle-polymer hybrid flocculant.

Abstract: Described herein is a charged particle-polymer hybrid flocculant that includes charged particles having an average size between about 150 nm and about 800 nm and each having a polymer polymerized thereon. Charged particle-polymer hybrid flocculants are made by forming charged particles having an average size between about 150 nm and about 800 nm; and polymerizing a monomer on the charged particles to form the polymer. Fine solids are separated from a suspension thereof by adding the charged particle polymer hybrid to the suspension to produce floccules and a supernatant, and separating the produced floccules from the supernatant.

Abstract: This invention relates to particulate and/or liquid droplet separation processes from liquids containing the same and the use of specific chemical additives to control surface wetting, hydrophobicity and surface forces in such processes.

Abstract: The present invention relates to a method for preparing 6-substituted amino-3-cyanoquinoline compounds (compound A for short) and the intermediates thereof, more particularly, to a compound of the following formula (I), the preparation method thereof, the intermediates thereof and use thereof for preparing the compound A. The compound of the formula (I) is cyclized in the presence of an alkali to give a compound of formula A, wherein W is OH; or the compound of the formula (I) is cyclized in the presence of an alkali, and then chlorinated to give a compound of the formula A, wherein W is Cl. Compared with the known methods in the literature, the method for preparing the compound A from the compound of formula (I) according to the present invention can avoid using high-temperature condition and high boiling point solvents, and is safe and environment-friendly, mild in reaction condition, easy in operation with a high yield and high product purity.

Abstract: The present invention relates to a process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof. The present invention provides a compound represented by formula I and a compound represented by formula II, and processes for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine by using the compound represented by formula I, the compound represented by formula II and o-nitrobenzaldehyde. The invention has the advantages of the shorter synthesis steps, easily available raw materials and simple operation. Moreover, the process is economic and safe by avoiding the use of expensive and dangerous lithium aluminum hydride.

Abstract: A charged particle polymer hybrid (CPPH) flocculant is taught, comprising sub-micron size charged particles and a polymer which has been polymerized in the presence of the charged particles wherein the intrinsic viscosity of the hybrid polymer flocculant is less than 930 ml/g. A method is provided for producing freely draining flocculated sediment from a suspension comprising finely divided solids in water. The method comprises dispersing, at increasing concentrations, a charged particle polymer hybrid (CPPH) flocculant into the suspension to determine a starting plateau concentration of CPPH flocculant above which concentration no further increase in the solids loading of the produced floccules is observed. Then, the concentration of dispersed CPPH flocculant in the suspension is maintained at or above the starting plateau concentration. A method is further provided for separating fine solids and water from a suspension comprising finely divided solids in water.

Abstract: The present invention relates to a method for preparing 6-substituted amino-3-cyanoquinoline compounds (compound A for short) and the intermediates thereof, more particularly, to a compound of the following formula (I), the preparation method thereof, the intermediates thereof and use thereof for preparing the compound A. The compound of the formula (I) is cyclized in the presence of an alkali to give a compound of formula A, wherein W is OH; or the compound of the formula (I) is cyclized in the presence of an alkali, and then chlorinated to give a compound of the formula A, wherein W is Cl. Compared with the known methods in the literature, the method for preparing the compound A from the compound of formula (I) according to the present invention can avoid using high-temperature condition and high boiling point solvents, and is safe and environment-friendly, mild in reaction condition, easy in operation with a high yield and high product purity.

Abstract: A method is taught for producing freely draining flocculated sediment from a suspension comprising finely divided solids in water. The method comprises dispersing, at increasing concentrations, a charged particle hybrid polymer (CPHP) flocculant into the suspension to determine a minimum concentration of CPHP flocculant above which a freely draining flocculated sediment is produced that has a minimum permeability of 1 Darcy. Then, the concentration of dispersed CPHP flocculant in the suspension is maintained at or above the minimum concentration. A method is further provided for separating fine solids and water from a suspension comprising finely divided solids in water. The method involves dispersing, at increasing concentrations, a charged particle hybrid polymer (CPHP) flocculant into the suspension to determine a minimum concentration of CPHP flocculant above which a freely draining flocculated sediment is produced that has a minimum permeability of 1 Darcy.

Abstract: This invention relates to particulate and/or liquid droplet separation processes from liquids containing the same and the use of specific chemical additives to control surface wetting, hydrophobicity and surface forces in such processes.

Abstract: The present invention relates to a process for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and the intermediates thereof. The present invention provides a compound represented by formula I and a compound represented by formula II, and processes for preparing 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine by using the compound represented by formula I, the compound represented by formula II and o-nitrobenzaldehyde. The invention has the advantages of the shorter synthesis steps, easily available raw materials and simple operation. Moreover, the process is economic and safe by avoiding the use of expensive and dangerous lithium aluminum hydride.