Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.

Abstract: The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates. The disclosure further provides methods of using the BCMA binding molecules to treat cancers that express cell surface BCMA. The disclosure yet further provides recombinant host cells engineered to express the BCMA binding molecules and methods of producing the BCMA binding molecules by culturing the host cells under conditions in which the BCMA binding molecules are expressed.

Abstract: For Direct Current (DC) bus voltage control, a method generates a q-axis reference current from a DC voltage error that includes a DC voltage input modified by a DC bus voltage in a closed outer loop. The method further generates a d-axis reference current from the DC voltage error, wherein the second-order harmonic in the d-axis reference current is delayed from that in q-axis reference current by 90 degrees. The method generates a q-axis current from the q-axis reference current. The method generates a d-axis current from the d-axis reference current. The second-order harmonic in d-axis current is offset from the second-order harmonic in q-axis current by 90 degrees. The method controls the DC bus voltage of a voltage control plant to mitigate a second-order harmonic in the DC bus voltage with the second-order harmonics in the q-axis current and the d-axis current.

Abstract: The present disclosure provides multispecific binding molecules that specifically bind to BCMA, a component of a human T-cell receptor complex and either CD2 or a tumor associated antigen, conjugates comprising the multispecific binding molecules, and pharmaceutical compositions comprising the multispecific binding molecules and the conjugates The disclosure further provides methods of using the multispecific binding molecules to treat disease and disorders associated with expression of BCMA. The disclosure yet further provides recombinant host cells engineered to express the multispecific binding molecules and methods of producing the multispecific binding molecules by culturing the host cells under conditions in which the multispecific binding molecules are expressed.

Abstract: The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates. The disclosure further provides methods of using the BCMA binding molecules to treat cancers that express cell surface BCMA. The disclosure yet further provides recombinant host cells engineered to express the BCMA binding molecules and methods of producing the BCMA binding molecules by culturing the host cells under conditions in which the BCMA binding molecules are expressed.

Abstract: The present disclosure relates to dosing regimens, formulations, and combinations comprising a multispecific antibody having at least binding specificity towards B cell maturation antigen (BCMA) and a T-cell engaging arm; and methods of using such multispecific antibodies in the treatment or prevention of disease, such as, cancer.

Abstract: For Direct Current (DC) bus voltage control, a method generates a q-axis reference current from a DC voltage error that includes a DC voltage input modified by a DC bus voltage in a closed outer loop. The method further generates a d-axis reference current from the DC voltage error, wherein the second-order harmonic in the d-axis reference current is delayed from that in q-axis reference current by 90 degrees. The method generates a q-axis current from the q-axis reference current. The method generates a d-axis current from the d-axis reference current. The second-order harmonic in d-axis current is offset from the second-order harmonic in q-axis current by 90 degrees. The method controls the DC bus voltage of a voltage control plant to mitigate a second-order harmonic in the DC bus voltage with the second-order harmonics in the q-axis current and the d-axis current.

Abstract: A system may include an inverter configured to convert a direct current (DC) voltage to an alternating current (AC) voltage. The system may also include a control system communicatively coupled to the inverter. The control system may receive a torque current feedback from a motor and may generate, based on the torque current feedback, a command torque current and a command flux current. The control system may generate, based on the command torque current and the command flux current, a command torque voltage and a command flux voltage and may generate, based on a slip frequency and a rotor frequency, a command frequency. The control system may determine one or more operating parameters for the inverter based on the command frequency, the command torque voltage, and the command flux voltage and may control the inverter based on the one or more operating parameters.

Abstract: A system may include an inverter configured to convert a direct current (DC) voltage to an alternating current (AC) voltage. The system may also include a control system communicatively coupled to the inverter. The control system may receive a torque current feedback from a motor and may generate, based on the torque current feedback, a command torque current and a command flux current. The control system may generate, based on the command torque current and the command flux current, a command torque voltage and a command flux voltage and may generate, based on a slip frequency and a rotor frequency, a command frequency. The control system may determine one or more operating parameters for the inverter based on the command frequency, the command torque voltage, and the command flux voltage and may control the inverter based on the one or more operating parameters.

Abstract: For grid-connected power converter control, a method estimates a d-axis grid voltage from a d-axis reference current modified with a d-axis current and a q-axis current modified with a filter inductive reactance. The method generates a q-axis current error from a direct current (DC) voltage input and a DC bus voltage. The method estimates an observer q-axis grid voltage from a q-axis voltage output. The q-axis grid voltage observer estimates the q-axis grid voltage in a direct/quadrature (dq) reference frame equivalent to an ABC to DQ reference frame transform. The method determines a d-axis voltage output as a function of a d-axis current error and a q-axis current modified with a filter inductive reactance. The method determines a q-axis voltage output as a sum of the q-axis current controller output and the observer q-axis grid voltage.

Abstract: The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.

Abstract: For grid-connected power converter control, a method estimates a d-axis grid voltage from a d-axis reference current modified with a d-axis current and a q-axis current modified with a filter inductive reactance. The method generates a q-axis current error from a direct current (DC) voltage input and a DC bus voltage. The method estimates an observer q-axis grid voltage from a q-axis voltage output. The q-axis grid voltage observer estimates the q-axis grid voltage in a direct/quadrature (dq) reference frame equivalent to an ABC to DQ reference frame transform. The method determines a d-axis voltage output as a function of a d-axis current error and a q-axis current modified with a filter inductive reactance. The method determines a q-axis voltage output as a sum of the q-axis current controller output and the observer q-axis grid voltage.

Abstract: The present disclosure relates to anti-CD32b antibody molecules which selectively bind human CD32b. Also provided herein are compositions comprising anti-CD32b antibody molecules in combination with other compounds, and methods of using the combinations to treat subject with cancer.

Abstract: For grid-connected power converter control, a method estimates a d-axis grid voltage from a d-axis reference current modified with a d-axis current, and a q-axis current modified with a filter inductive reactance. The method generates a q-axis grid voltage from a direct current (DC) voltage input modified with the DC bus voltage modified with a notch filter to balance the voltage input and further reduced with the q-axis current. The method modifies the estimated d-axis grid voltage and the q-axis grid voltage by selectively removing second-order harmonics. The method further determines a d-axis voltage output and a q-axis voltage output as a function of the modified estimated d-axis grid voltage and the modified q-axis grid voltage.

Abstract: For grid-connected power converter control, a method estimates a d-axis grid voltage from a d-axis reference current modified with a d-axis current, and a q-axis current modified with a filter inductive reactance. The method generates a q-axis grid voltage from a direct current (DC) voltage input modified with the DC bus voltage modified with a notch filter to balance the voltage input and further reduced with the q-axis current. The method modifies the estimated d-axis grid voltage and the q-axis grid voltage by selectively removing second-order harmonics. The method further determines a d-axis voltage output and a q-axis voltage output as a function of the modified estimated d-axis grid voltage and the modified q-axis grid voltage.

Abstract: For predicting a load pattern, a method determines a torque error from a torque reference modified by a low pass filter function of the torque reference. The torque reference is one of measured from an induction machine energized by a flux current and a torque current and calculated in an induction machine controller. The method determines a torque increase pulse in response to a torque relative variation calculated from the torque error exceeding an increase threshold. In response to detecting the torque increase pulse, the method determines a change delay time from the torque relative variation and the torque increase pulse. The method further determines a change period from at least two torque increase pulses. The method increases the flux current before a change time that is predicted as a function of the change delay time and the change period.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to a method of administering a BCMA-targeting agent which is an anti-BCMA antibody molecule or a recombinant non-antibody protein that binds to BCMA, and a gamma secretase inhibitor.

Abstract: The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates. The disclosure further provides methods of using the BCMA binding molecules to treat cancers that express cell surface BCMA. The disclosure yet further provides recombinant host cells engineered to express the BCMA binding molecules and methods of producing the BCMA binding molecules by culturing the host cells under conditions in which the BCMA binding molecules are expressed.

Abstract: For reducing volume requirements and magnetic flux leakage, a compact inductor includes a first planar core with a first core thickness along a first axis orthogonal to a plane of the first planar core. In addition, the inductor includes a second planar core disposed parallel to the first planar core with a second core thickness along the first axis. The inductor further includes a plurality of electrical windings disposed between and adjacent to an inside plane of the first planar core and an inside plane of the second planar core. The electrical windings may include insulated electrical wires. No magnetic teeth may be disposed between the first planar core and the second planar core. The first axis is parallel to a magnetic axis of each electrical winding.

Abstract: The present techniques include methods and systems for operating converter to maintain a lifespan of the converter. In some embodiments, the operating frequency of the converter may be increased such that stress may be reduced on the bond wires of the converter. More specifically, embodiments involve calculating the aging parameters for certain operating conditions of the converter operating in a maximum power point tracking (MPPT) mode and determining whether the MPPT operation results in aging the converter to a point which reduces the converter lifespan below a desired lifespan. If the MPPT operation reduces the converter lifespan below the desired lifespan, the frequency of the converter may be increased such that the converter may be controlled to operate at a percentage of MPPT. Thus, in some embodiments, power output may be optimized with respect to maintaining a desired lifespan of the converter.