Abstract: Disclosed are a method for preparing exosomes from bovine placenta, lyophilized powder of the exosomes, as well as a composition containing exosomes from animal placenta and a preparation method and use thereof in anti-wrinkle on skin.

Abstract: The present invention provides a serum-free polypeptide composition for promoting proliferation of mesenchymal stem cells. The composition mainly comprises: 10-100 ?g/L of tripeptide-1; 1-20 ?g/L of tripeptide-2, 1-20 ?g/L of hexapeptide-9, 1-20 ?g/L of palmitoyl hexapeptide-12; and 10-100 ?g/L of a laminin-derived peptide. The serum-free polypeptide composition provided in the present disclosure has clear chemical components without animal origins or serum, can achieve rapid proliferation of the mesenchymal stem cells, and maintains the biological characteristics and immunophenotypic stability of the mesenchymal stem cells while solving the problem of the insufficient quantity of cells.

Abstract: The present invention relates to the field of stem cell technology, and in particular to a stem cell preparation and its application in the preparation of drugs for the treatment of osteoarthritis (OA). The composition provided by the invention can significantly improve the activity of umbilical cord mesenchymal stem cells under cryopreservation conditions, and the stem cell preparation prepared therefrom has a good effect on repairing cartilage injury caused by OA, thereby playing a role in the treatment of OA.