Patents by Inventor Haijia YU

Haijia YU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PD-L1 ANTIGEN BINDING PROTEIN AND USE THEREOF
    Publication number: 20250074988
    Abstract: A PD-L1 antigen binding protein and an application thereof. The antigen binding protein has one or more of the following properties: binding to a PD-L1 protein at an EC50 value of 0.07 ?g/ml or above; blocking binding between the PD-L1 protein and a PD-1 protein; promoting the activation of a T cell; and inhibiting the volume increase of the in vivo tumor. An application of the antigen binding protein in the preparation of a drug for treating tumor.
    Type: Application
    Filed: December 14, 2022
    Publication date: March 6, 2025
    Inventors: Xiaoyue WEI, Xiangyang ZHU, Haijia YU, Shi CHEN, Yanting WANG, Xiaochen REN, Xiaopei CUI, Huifeng JIA
  • CD73-BINDING PROTEIN AND USE THEREOF
    Publication number: 20240067747
    Abstract: Provided is an isolated antigen-binding protein, which can specifically bind to CD73 and includes at least one CDR in a heavy chain variable region VH, wherein the region VH includes an amino acid sequence as represented by SEQ ID NO: 49.
    Type: Application
    Filed: January 12, 2022
    Publication date: February 29, 2024
    Inventors: Jingen XU, Xiangyang ZHU, Haijia YU, Xiaoyue WEI, Lili QU, Xiaochen REN
  • CD73 ANTIGEN-BINDING PROTEIN AND APPLICATION THEREOF
    Publication number: 20240026024
    Abstract: Provided is an isolated antigen-binding protein, capable of binding to CD73. The isolated antigen-binding protein contains HCDR3, and the HCDR3 comprises an amino acid sequences as shown in SEQ ID No.:3. Also provided are a preparation method for the antigen-binding protein, and an application of the antigen-binding protein.
    Type: Application
    Filed: December 10, 2021
    Publication date: January 25, 2024
    Inventors: Jingen XU, Xiangyang ZHU, Haijia YU, Xiaoyue WEI, Ling TONG, Shi CHEN
  • BISPECIFIC ANTIBODY AND USE THEREOF
    Publication number: 20240010730
    Abstract: Provided in the present application is a multispecific antibody, which includes a first targeting moiety capable of specifically binding to the TIGIT protein and a second targeting moiety capable of binding to a tumor-associated antigen, and the multispecific antibody can be used to treat a tumor. Further provided in the present application is the use of the multispecific antibody as a drug.
    Type: Application
    Filed: November 25, 2021
    Publication date: January 11, 2024
    Inventors: Xiangyang ZHU, Xiaopei CUI, Jingen XU, Haijia YU
  • ANTIBODY TARGETING INTERLEUKIN 36R, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Publication number: 20230399409
    Abstract: The present application provides an antibody targeting interleukin 36R, a preparation method therefor, and an application thereof. Specifically, the present application provides an IL-36R antibody having high affinity and high bioactivity. The antibody can bind to IL-36R with high affinity, and can block the binding between an IL-36R ligand (?, ?. ?) and the IL-36R and a signal path activated by the IL-36R ligand, thereby treating and/or preventing IL-36 related diseases.
    Type: Application
    Filed: November 4, 2021
    Publication date: December 14, 2023
    Inventors: Yujie FENG, Haijia YU, Xiaoyue WEI, Guoyuan PENG, Shi CHEN, Lili QU
  • ANTI-TIGIT ANTIBODY AND PREPARATION METHOD AND APPLICATION THEREOF
    Publication number: 20230183345
    Abstract: Provided is a separated antigen-binding protein. The antigen-binding protein comprises at least one CDR in a heavy chain variable region VH, and the VH comprises an amino acid sequence shown in SEQ ID NO: 55. Also provided are an anti-TIGIT antibody, and a preparation method and an application thereof. The antigen-binding protein can specifically bind with a TIGIT antigen to block the binding of TIGIT and a ligand thereof, and can be used for preparing drugs for preventing or treating TIGIT-related diseases.
    Type: Application
    Filed: May 7, 2021
    Publication date: June 15, 2023
    Inventors: Haijia YU, Mingqing CAI, Xiaoyue WEI, Shi CHEN, Jianmei XIE, Xiangyang ZHU
  • BINDER AGAINST PROGRAMMED DEATH-LIGAND AND APPLICATION THEREOF
    Publication number: 20220089741
    Abstract: Provided is an anti-PD-L1 monoclonal antibody. The antibody can be used to prepare a drug for preventing or treating a disease related to PD-L1.
    Type: Application
    Filed: March 10, 2020
    Publication date: March 24, 2022
    Inventors: Haijia YU, Ling YU, Mingqing CAI, Xiangyang ZHU
  • Antibody targeting interleukin 17A and preparation method and application thereof
    Patent number: 10981983
    Abstract: The present invention provides an antibody targeted to interleukin 17A (IL-17A), preparation method and the use thereof. In particular, the invention provides a novel anti-IL-17A monoclonal antibody. The antibody of the present invention is capable of binding IL-17A antigen with high specificity, has high affinity and low immunogenicity, and is used for preparing a medicament for preventing or treating an IL-17A-related disease such as various inflammatory or autoimmune diseases.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: April 20, 2021
    Assignee: Huabo Biopharm (Shanghai) Co., Ltd.
    Inventors: Xiangyang Zhu, Mingqing Cai, Haijia Yu, Huifeng Jia, Ling Yu
  • ANTIBODY TARGETING INTERLEUKIN 17A AND PREPARATION METHOD AND APPLICATION THEREOF
    Publication number: 20200071394
    Abstract: The present invention provides an antibody targeted to interleukin 17A (IL-17A), preparation method and the use thereof. In particular, the invention provides a novel anti-IL-17A monoclonal antibody. The antibody of the present invention is capable of binding IL-17A antigen with high specificity, has high affinity and low immunogenicity, and is used for preparing a medicament for preventing or treating an IL-17A-related disease such as various inflammatory or autoimmune diseases.
    Type: Application
    Filed: January 19, 2018
    Publication date: March 5, 2020
    Inventors: Xiangyang ZHU, Mingqing CAI, Haijia YU, Huifeng JIA, Ling YU