Patents by Inventor Haijian Zhu

Haijian Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Palonosetron oral transmucosal film or patch
    Patent number: 9937122
    Abstract: The present invention provides a pharmaceutical composition for delivering palonosetron through the buccal mucosa or sublingual mucosa. The pharmaceutical composition comprises 0.05-35% (w/w) of palonosetron, 40-90% of a film forming agent, 1-10% (w/w) of a plasticizer, 5-25% (w/v) of an adhesive agent, and 0.1-5% of a penetration enhancing agent. A preferred plasticizer is a polysorbate. A preferred adhesive agent is polyvinylpyrrolidone or carboxymethylcellulose. A preferred penetration enhancing agent is peppermint oil or menthol.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: April 10, 2018
    Assignee: XIAMEN LP PHARMACEUTICAL CO., LTD.
    Inventors: Haijian Zhu, Rongbin Ling, Qing Luo, Ying Ye
  • PALONOSETRON ORAL TRANSMUCOSAL FILM OR PATCH
    Publication number: 20170367969
    Abstract: The present invention provides a pharmaceutical composition for delivering palonosetron through the buccal mucosa or sublingual mucosa. The pharmaceutical composition comprises 0.05-35% (w/w) of palonosetron, 40-90% of a film forming agent, 1-10% (w/w) of a plasticizer, 5-25% (w/v) of an adhesive agent, and 0.1-5% of a penetration enhancing agent. A preferred plasticizer is a polysorbate. A preferred adhesive agent is polyvinylpyrrolidone or carboxymethylcellulose. A preferred penetration enhancing agent is peppermint oil or menthol.
    Type: Application
    Filed: July 12, 2016
    Publication date: December 28, 2017
    Inventors: Haijian Zhu, Rongbin Ling, Qing Luo, Ying Ye
  • Solvate and crystalline forms of carbamoyl-cyclohexane derivatives
    Patent number: 8609665
    Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: December 17, 2013
    Inventors: Xiangmin Liao, Haijian Zhu, Andreas Grill
  • CRYSTALLINE FORM OF LINACLOTIDE
    Publication number: 20120214750
    Abstract: The present invention relates to crystalline forms of linaclotide, as well as to various methods and processes for the preparation and use of the crystalline forms.
    Type: Application
    Filed: April 27, 2012
    Publication date: August 23, 2012
    Applicant: FOREST LABORATORIES HOLDINGS LTD.
    Inventors: Ritesh Sanghvi, Andreas Grill, Rahul Surana, Haijian Zhu
  • Crystalline form of linaclotide
    Patent number: 8222201
    Abstract: The present invention relates to crystalline forms of linaclotide, as well as to various methods and processes for the preparation and use of the crystalline forms.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: July 17, 2012
    Inventors: Ritesh Sanghvi, Andreas Grill, Rahul Surana, Haijian Zhu
  • NOVEL SOLVATE AND CRYSTALLINE FORMS OF CARBAMOYL-CYCLOHEXANE DERIVATIVES
    Publication number: 20110028722
    Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Application
    Filed: October 5, 2010
    Publication date: February 3, 2011
    Inventors: Xiangmin Liao, Haijian Zhu, Andreas Grill
  • Solvate and crystalline forms of carbamoyl-cyclohexane derivatives
    Patent number: 7829569
    Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: November 9, 2010
    Assignee: Forest Laboratories Holdings Limited
    Inventors: Xiangmin Liao, Haijian Zhu, Andreas Grill
  • CRYSTALLINE FORM OF LINACLOTIDE
    Publication number: 20100125056
    Abstract: The present invention relates to crystalline forms of linaclotide, as well as to various methods and processes for the preparation and use of the crystalline forms.
    Type: Application
    Filed: November 18, 2009
    Publication date: May 20, 2010
    Inventors: Ritesh Sanghvi, Andreas Grill, Rahul Surana, Haijian Zhu
  • NOVEL CRYSTALLINE FORM OF 2-[4-(4-FLUORO-BENZYL)-PIPERIDINE-1-YL]-2-OXO-N-(2-OXO-2,3-DIHYDRO-BENZOXAZOL-6-YL)-ACETAMIDE
    Publication number: 20100010044
    Abstract: The present invention relates to a novel crystalline form of 2-[4-(4-fluoro-benzyl)-piperidine-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide. Processes for the preparation of this form, compositions containing the form, and methods of use thereof are also described.
    Type: Application
    Filed: July 8, 2009
    Publication date: January 14, 2010
    Applicant: Forest Laboratories Holdings Limited
    Inventors: Alphonso HIGUERA, Haijian ZHU, Andreas GRILL
  • NOVEL SOLVATE AND CRYSTALLINE FORMS OF CARBAMOYL-CYCLOHEXANE DERIVATIVES
    Publication number: 20090030007
    Abstract: The present invention relates to novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives and, more particularly, to novel solvate and crystalline forms of trans-1{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3,3-dimethyl-urea hydrochloride. Processes for the preparation of these forms, compositions containing these forms, and methods of use thereof are also described.
    Type: Application
    Filed: May 9, 2008
    Publication date: January 29, 2009
    Applicant: FOREST LABORATORIES HOLDINGS LIMITED
    Inventors: Xiangmin Liao, Haijian Zhu, Andreas Grill