Abstract: The present application provides an electric vehicle and a thermal manager thereof. The thermal manager includes a housing, and a plurality of heat transfer tube sets are accommodated in the housing, and each heat transfer tube set is used for connecting a device; a valve assembly is arranged on a front surface of the housing, and the valve assembly is provided with a plurality of valve ports; each valve port is opposite to and communicates with a second end of at least one heat transfer branch tube in a front-and-rear direction, and the two heat transfer branch tubes in a same set are each in communication with a different valve port; the valve assembly is used to selectively communicate with a different valve port when the thermal manager performs mode switching. The electric vehicle includes a motor, a battery, a radiator and the thermal manager as above.

Abstract: A multi-way valve, related to the technical field of control valves, is used to solve the problem of large occupied space, complicated control, and high cost, because of the use of two driving devices for controlling a three-way proportional valve and a two-way proportional valve, where a driving device is connected to a first valve core in a transmission way, and the first valve core is provided with a first matching structure, and a second valve core is provided with a second matching structure that matches the first matching structure. In the first matching state, the first valve core rotates alone and the second valve core remains stationary; in the second matching state, the first valve core rotates to drive the second valve core to rotate synchronously.

Abstract: A multi-way valve includes a valve seat and a valve core. The valve core is rotatably disposed in the valve seat, the valve seat is provided with a plurality of valve port groups, each valve port group includes a plurality of valve ports, the valve core is provided with communication structure groups corresponding to the valve port groups, respectively, and each of the communication structure groups further includes a plurality of communication structures arranged along a circumferential direction of the valve core. When the valve core is rotated to different rotation positions, valve ports in different valve port groups form different communication states. Only one valve core is required to make a two-way proportional valves, three-way proportional valve, and a four-way proportional valve achieve different communication states, with simple control, compact structure and low cost.

Abstract: Aspects of the disclosure relate to compositions and methods for expressing anti-Vascular endothelial cell growth factor (VEGF) agent in a cell or subject. In some embodiments, the disclosure provides rAAVs comprising a capsid protein (e.g., AAV2 variants, AAV2/3 hybrid variants, AAV8 variants, etc.), and a transgene encoding an anti-VEGF agent (e.g., KH902) and one or more regulatory sequences. In some embodiments, compositions described herein are useful for treating subjects having diseases associated with angiogenesis or aberrant VEGF activity/signaling.

Abstract: Aspects of the disclosure relate to compositions and methods for expressing anti-Vascular endothelial cell growth factor (VEGF) agent in a cell or subject. In some embodiments, the disclosure provides rAAVs comprising a capsid protein (e.g., AAV2 variants, AAV2/3 hybrid variants, AAV8 variants, etc.), and a transgene encoding an anti-VEGF agent (e.g., KH902) and one or more regulatory sequences. In some embodiments, compositions described herein are useful for treating subjects having diseases associated with angiogenesis or aberrant VEGF activity/signaling.