Abstract: A piperazine substituted phenol derivative and its applications in pharmaceutical chemistry are provided. The compound, depicted by formula I, exhibits excellent salt formation properties and water solubility, meeting formulation requirements. It also has a low minimum effective anesthetic dose, enabling rapid onset and recovery. This addresses the drawbacks of propofol and ciprofol prodrugs and lipid emulsions. The compound shows promise in developing drugs with sedative, hypnotic, and/or anesthetic effects, as well as in drugs for controlling status epilepticus.

Abstract: Disclosed in the present invention are a substituted nitrogen heterocyclic compound and anesthetic action thereof. Specifically provided a chemical compound as shown in formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug thereof, a metabolite thereof or a deuterated derivative thereof. The substituted nitrogen heterocyclic compound provided in the present application has good central nervous system inhibition effects, capable of generating sedative, hypnotic and/or general anesthetic effects, and capable of controlling status epilepticus; said substituted nitrogen heterocyclic compound is also characterized by rapid onset of action and rapid recovery, while maintaining positive anesthetic activity; in addition, said substituted nitrogen heterocyclic compound has almost no inhibitory effect on adrenocortical function, low side effects, and resolves technical difficulties in the art.

Abstract: The invention provides a steel cord with a construction of n×1, n is the number of the steel filaments of the steel cord, the steel cord has an elongation at 2.5N-50N of less than 1.2% and a twist pitch of greater than 16 mm, each of the steel filaments has a form of helical wave with a wave length L expressed in mm and a wave height H expressed in mm when being unravelled from said steel cord, L is greater than 16 mm, each of the steel filaments has a space volume Vs satisfying that, Vs=L×H2×?/4, and Vs>20 mm3. The invention steel cord is beneficial for the stress distribution.

Abstract: The invention provides a steel cord, the steel cord comprises two or more steel filaments, at least one of the steel filaments has a twist pitch of 6 mm to 40 mm, each of the steel filaments has a tip rise of less than 5 mm with a gauge length of 200 mm after being unravelled out of the steel cord. The invention steel cord has an improved straightness with reduced steel filament fracture risk.

Abstract: The invention provides a steel cord, the steel cord comprises two or more steel filaments, at least one of the steel filaments has a twist pitch of 6 mm to 40 mm, each of the steel filaments has a tip rise of less than 5 mm with a gauge length of 200 mm after being unravelled out of the steel cord. The invention steel cord has an improved straightness with reduced steel filament fracture risk.

Abstract: The invention provides a steel cord with a construction of n×1, n is the number of the steel filaments of the steel cord, the steel cord has an elongation at 2.5N-50N of less than 1.2% and a twist pitch of greater than 16 mm, each of the steel filaments has a form of helical wave with a wave length L expressed in mm and a wave height H expressed in mm when being unravelled from said steel cord, L is greater than 16 mm, each of the steel filaments has a space volume Vs satisfying that, Vs=L×H2×?/4, and Vs>20 mm3. The invention steel cord is beneficial for the stress distribution.

Abstract: Disclosed in the present invention are a substituted nitrogen heterocyclic compound and anesthetic action thereof. Specifically provided a chemical compound as shown in formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug thereof, a metabolite thereof or a deuterated derivative thereof. The substituted nitrogen heterocyclic compound provided in the present application has good central nervous system inhibition effects, capable of generating sedative, hypnotic and/or general anesthetic effects, and capable of controlling status epilepticus; said substituted nitrogen heterocyclic compound is also characterized by rapid onset of action and rapid recovery, while maintaining positive anesthetic activity; in addition, said substituted nitrogen heterocyclic compound has almost no inhibitory effect on adrenocortical function, low side effects, and resolves technical difficulties in the art.

Abstract: A compound is shown in formula (I). The derivatives of the compound include a stereoisomer, a pharmaceutically acceptable salt, a solvate, a prodrug, a metabolite, a deuterated derivative. The compound is a structurally novel substituted imidazole formate derivative. Substituted imidazole formate derivatives are used in preparing a drug with sedative, hypnotic and/or anesthetic effects, as well as a drug that can control the state of epilepsy. The compound has a good inhibitory effect on the central nervous system, and provides a new option for clinical screening of and/or preparation of a drug with sedative, hypnotic and/or anesthetic effects and controlling the state of epilepsy.

Abstract: A high-speed hydraulic forging press is disclosed. The high-speed hydraulic forging press includes a forging hammer, a movable beam, a main hydraulic cylinder, a single-rod elevation hydraulic cylinder, a plurality of main hydraulic pumps, a high-pressure energy accumulator, an intermediate-pressure energy accumulator, an oil tank, a programmable logic controller and a valve-regulation system. During a rolling process, when a rolling resistance applied to the forging hammer increases to cause pressure in the main hydraulic cylinder to reach a predetermined value, the programmable logic controller controls the valve-regulation system so that the high-pressure energy accumulator stops supplying the hydraulic oil to the main hydraulic cylinder, and that the hydraulic oil in the main hydraulic cylinder is supplied by at least one of the plurality of main hydraulic pumps.

Abstract: A compound is shown in formula (I). The derivatives of the compound include a stereoisomer, a pharmaceutically acceptable salt, a solvate, a prodrug, a metabolite, a deuterated derivative. The compound is a structurally novel substituted imidazole formate derivative. Substituted imidazole formate derivatives are used in preparing a drug with sedative, hypnotic and/or anesthetic effects, as well as a drug that can control the state of epilepsy. The compound has a good inhibitory effect on the central nervous system, and provides a new option for clinical screening of and/or preparation of a drug with sedative, hypnotic and/or anesthetic effects and controlling the state of epilepsy.

Abstract: A hydraulic forging machine and a method for replacing an upper anvil block thereof are disclosed. The hydraulic forging machine includes locking hydraulic cylinder that is fixed to a movable beam of the hydraulic forging machine when the hydraulic forging machine is in operation. The locking hydraulic cylinder is configured to provide a locking-unlocking function between an upper anvil block of the hydraulic forging machine and the movable beam. The locking hydraulic cylinder has its hydraulic power source supplied from a main hydraulic cylinder or a return hydraulic cylinder, which is also fixed to the movable beam. The present disclosure not only enables an oil supply circuit for the locking hydraulic cylinder to move together with the movable beam, but also simplifies the oil supply circuit for the locking hydraulic cylinder, resulting in an improved reliability of the hydraulic forging machine.

Abstract: A high-speed hydraulic forging press is disclosed. The high-speed hydraulic forging press includes a forging hammer, a movable beam, a main hydraulic cylinder, a single-rod elevation hydraulic cylinder, a plurality of main hydraulic pumps, a high-pressure energy accumulator, an intermediate-pressure energy accumulator, an oil tank, a programmable logic controller and a valve-regulation system. During a rolling process, when a rolling resistance applied to the forging hammer increases to cause pressure in the main hydraulic cylinder to reach a predetermined value, the programmable logic controller controls the valve-regulation system so that the high-pressure energy accumulator stops supplying the hydraulic oil to the main hydraulic cylinder, and that the hydraulic oil in the main hydraulic cylinder is supplied by at least one of the plurality of main hydraulic pumps.