Patents by Inventor Haile Tecle

Haile Tecle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfohydroxamic acids and sulfohydroxamates and their use as MEK inhibitors
    Patent number: 6835749
    Abstract: Sulfohydroxamic acid diarylamines and derivatives thereof; compositions made from them; and methods of using them.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: December 28, 2004
    Assignee: Warner Lambert Company
    Inventor: Haile Tecle
  • 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
    Patent number: 6821963
    Abstract: Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: November 23, 2004
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Annette Marian Doherty, David Thomas Dudley, Alan Robert Saltiel, Haile Tecle
  • Benzenesulfonamide derivatives and their use as MEK inhibitors
    Patent number: 6750217
    Abstract: Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: June 15, 2004
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Haile Tecle, Richard John Booth
  • Oxygenated esters of 4-lodo phenylamino benzhydroxamic acids
    Publication number: 20040054172
    Abstract: The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystaline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: June 19, 2003
    Publication date: March 18, 2004
    Inventors: Stephen Douglas Barrett, Cathlin Marie Biwersi, Michael Huai Gu Chen, Michael David Kaufman, Haile Tecle, Joseph Scott Warmus
  • N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
    Publication number: 20040006245
    Abstract: The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: January 23, 2003
    Publication date: January 8, 2004
    Inventors: Gordon William Rewcastle, Julie Ann Spicer, Stephen Douglas Barrett, Michael David Kaufman, Jared Bruce John Milbank, Haile Tecle
  • Modified MEK1 and MEK2, crystal of a peptide: ligand: cofactor complex containing such modified MEK1 or MEK2, and methods of use thereof
    Publication number: 20030224500
    Abstract: Modified MEK1 peptides and modified MEK2 peptides, polynucleotides encoding those peptides, and methods for purifying the peptides and crystallizing them as peptide: cofactor: ligand complexes have been discovered. The three-dimensional structures of MEK1 peptide and MEK2 peptide, including the cofactor- and ligand-binding pockets, and uses of this information, for example, in molecular replacement and the modification, design and screening of compounds that may associate with MEK1, MEK2, or peptides structurally related thereto, have also been discovered.
    Type: Application
    Filed: December 20, 2002
    Publication date: December 4, 2003
    Inventors: Jeffrey F. Ohren, Huifen Chen, Amy Marie Delaney, David Thomas Dudley, Charles A. Hasemann, Peter Kuffa, Patrick C. McConnell, Alexander Gregory Pavlovsky, Haile Tecle, Christopher E. Whitehead, Chunhong Yan, Erli Zhang
  • 5-Amide substituted diarylamines as mex inhibitors
    Publication number: 20030225076
    Abstract: Diarylanines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are useful in the treatment of a variety of proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.
    Type: Application
    Filed: September 13, 2002
    Publication date: December 4, 2003
    Inventors: Cathlin Biwersi, Haile Tecle, Joseph Scott Warmus
  • 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives
    Publication number: 20030149015
    Abstract: Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula 1
    Type: Application
    Filed: December 10, 2002
    Publication date: August 7, 2003
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Donna Reynolds Cody, Annette Marian Doherty, David Thomas Dudley, Alan Robert Saltiel, Mel Conrad Schroeder, Haile Tecle
  • Benzenesulfonamide derivatives and their use as MEK inhibitors
    Publication number: 20030092748
    Abstract: 1
    Type: Application
    Filed: July 18, 2002
    Publication date: May 15, 2003
    Inventors: Stephen Douglas Barrett, Haile Tecle, Richard John Booth
  • 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
    Publication number: 20030078428
    Abstract: Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
    Type: Application
    Filed: June 4, 2002
    Publication date: April 24, 2003
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Annette Marian Doherty, David Thomas Dudley, Alan Robert Saltiel, Haile Tecle
  • 1-heterocycle substituted diarylamines
    Patent number: 6545030
    Abstract: 1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: April 8, 2003
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Haile Tecle, Lu-Yan Zhang
  • Sulfohydroxamic acids and sulfohydroxamates and their use as MEK inhibitors
    Publication number: 20030045521
    Abstract: Sulfohydroxamic acid diarylamines and derivatives thereof; compositions made from them; and methods of using them.
    Type: Application
    Filed: September 13, 2002
    Publication date: March 6, 2003
    Inventor: Haile Tecle
  • 4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
    Patent number: 6506798
    Abstract: The invention provides compounds of formula (II), wherein Ar, R3, R4, R5, R6, R7, R8 and W have the meanings given in the description. They are selective MEK inhibitors.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: January 14, 2003
    Assignee: Warner-Lambert Company
    Inventors: Stephen Barrett, Haile Tecle
  • 1-Heterocycle substituted diarylamines
    Publication number: 20030004193
    Abstract: 1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
    Type: Application
    Filed: July 23, 2002
    Publication date: January 2, 2003
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Haile Tecle, Lu-Yan Zhang
  • 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives
    Patent number: 6492363
    Abstract: Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: December 10, 2002
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Donna Reynolds Cody, Annette Marian Doherty, David Thomas Dudley, Alan Robert Saltiel, Mel Conrad Schroeder, Haile Tecle
  • Benzoheterocycles and their uses as MEK inhibitors
    Patent number: 6469004
    Abstract: The invention provides compounds having formula (I), wherein W is OH, or derivatives of the carboxylic acid, and Q is a heterocyclo-condensed ortho-phenylene residue. These compounds are useful as MEK inhibitors, particularly in the treatment of proliferative diseases such as cancer.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: October 22, 2002
    Assignee: Warner-Lambert Company
    Inventors: Stephen Barrett, Haile Tecle, Alexander J. Bridges
  • Sulohydroxamic acids and sulohyroxamates and their use as MEK inhibitors
    Patent number: 6455582
    Abstract: Sulfohydroxamic acid diarylamines of formula (I), in which the variables are as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: September 24, 2002
    Assignee: Warner-Lambert Company
    Inventor: Haile Tecle
  • Benzenesulfonamide derivatives and their use as MEK inhibitors
    Patent number: 6440966
    Abstract: Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: August 27, 2002
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Haile Tecle, Richard John Booth
  • 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives
    Publication number: 20020022647
    Abstract: Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula 1
    Type: Application
    Filed: August 16, 2001
    Publication date: February 21, 2002
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Donna Reynolds Cody, Annette Marian Doherty, David Thomas Dudley, Alan Robert Saltiel, Mel Conrad Schroeder, Haile Tecle
  • 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
    Patent number: 6310060
    Abstract: Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: October 30, 2001
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Donna Reynolds Cody, Annette Marian Doherty, David Thomas Dudley, Alan Robert Saltiel, Mel Conrad Schroeder, Haile Tecle