Patents by Inventor Haim Bar-Simantov
Haim Bar-Simantov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210290985Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: ApplicationFiled: June 7, 2021Publication date: September 23, 2021Applicant: Sol-Gel Technologies Ltd.Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
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Patent number: 11071878Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: GrantFiled: March 19, 2018Date of Patent: July 27, 2021Assignee: Sol-Gel Technologies Ltd.Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
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METHOD FOR PREPARING PARTICLES COMPRISING METAL OXIDE COATING AND PARTICLES WITH METAL OXIDE COATING
Publication number: 20210007996Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.Type: ApplicationFiled: September 10, 2020Publication date: January 14, 2021Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer TOLEDANO, Haim Bar-Simantov, Nissim Bilman, Leora Shapiro, Raed Abu-Reziq, Hanan Sertchook -
Publication number: 20200405665Abstract: The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.Type: ApplicationFiled: September 10, 2020Publication date: December 31, 2020Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Hanan SERTCHOOK, Ofer Toledano, Haim Bar-Simantov
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METHOD FOR PREPARING PARTICLES COMPRISING METAL OXIDE COATING AND PARTICLES WITH METAL OXIDE COATING
Publication number: 20200383927Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.Type: ApplicationFiled: August 25, 2020Publication date: December 10, 2020Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer TOLEDANO, Haim BAR-SIMANTOV, Nissim BILMAN, Leora SHAPIRO, Raed ABU-REZIQ, Hanan SERTCHOOK -
Patent number: 10653899Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: GrantFiled: August 2, 2018Date of Patent: May 19, 2020Assignee: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
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Patent number: 10525433Abstract: A process for preparing nanocapsules having a core-shell structure, comprising: (a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.Type: GrantFiled: December 12, 2007Date of Patent: January 7, 2020Assignee: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Hanan Sertchook, Raed Abu-Reziq, Haim Bar-Simantov, Leora Shapiro
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Patent number: 10512796Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: GrantFiled: December 30, 2010Date of Patent: December 24, 2019Assignee: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco-Dagan
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Publication number: 20180339176Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: ApplicationFiled: August 2, 2018Publication date: November 29, 2018Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer TOLEDANO, Haim BAR-SIMANTOV, Hanan SERTCHOOK, Sharon FIREMAN-SHORESH, Dorit MARCO
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Publication number: 20180207451Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: ApplicationFiled: March 19, 2018Publication date: July 26, 2018Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer TOLEDANO, Haim BAR-SIMANTOV, Hanan SERTCHOOK, Sharon FIREMAN-SHORESH, Dorit MARCO
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Publication number: 20180147165Abstract: The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.Type: ApplicationFiled: January 25, 2018Publication date: May 31, 2018Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Hanan Sertchook, Ofer Toledano, Haim Bar-Simantov
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Publication number: 20180117369Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: ApplicationFiled: December 7, 2017Publication date: May 3, 2018Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
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Patent number: 9868103Abstract: The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer. The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.Type: GrantFiled: August 2, 2006Date of Patent: January 16, 2018Assignee: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Hanan Sertchook, Natalia Loboda, Haim Bar-Simantov
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Publication number: 20170281571Abstract: The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.Type: ApplicationFiled: April 25, 2017Publication date: October 5, 2017Inventors: Hanan SERTCHOOK, Ofer TOLEDANO, Haim BAR-SIMANTOV
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Patent number: 9687465Abstract: The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.Type: GrantFiled: November 27, 2012Date of Patent: June 27, 2017Assignee: SOL-GEL TECHNOLOGIES LTD.Inventors: Hanan Sertchook, Ofer Toledano, Haim Bar-Simantov
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Publication number: 20140147396Abstract: The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.Type: ApplicationFiled: November 27, 2012Publication date: May 29, 2014Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Hanan SERTCHOOK, Ofer TOLEDANO, Haim BAR-SIMANTOV
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Patent number: 8617580Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.Type: GrantFiled: June 13, 2012Date of Patent: December 31, 2013Assignee: Sol-Gel Technologies Ltd.Inventors: Ofer Toledano, Hanan Sertchook, Natalia Loboda, Haim Bar-Simantov, Leora Shapiro, Raed Abu-Reziq
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Publication number: 20130095185Abstract: The present disclosure relates to compositions for topical application, where the compositions comprise microcapsules having a core that comprises benzoyl peroxide and a shell that comprises an inorganic polymer, microcapsules having a core that comprises a retinoid and a shell that comprises an inorganic polymer, and a stabilizing agent. The composition can be in a variety of forms, such as emulsion and gel.Type: ApplicationFiled: June 29, 2012Publication date: April 18, 2013Applicant: MEDICIS PHARAMACEUTICAL CORPORATIONInventors: Ofer TOLEDANO, Haim BAR-SIMANTOV
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Publication number: 20120269874Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.Type: ApplicationFiled: June 13, 2012Publication date: October 25, 2012Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer TOLEDANO, Hanan SERTCHOOK, Natalia LOBODA, Haim BAR-SIMANTOV, Leora SHAPIRO, Raed ABU-REZIQ
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Publication number: 20120202695Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: ApplicationFiled: December 30, 2010Publication date: August 9, 2012Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco-Dagan