Patents by Inventor Haim Leader

Haim Leader has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
    Patent number: 10688330
    Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: June 23, 2020
    Assignees: Yeda Research and Development Co. Ltd., University of Washington
    Inventors: Dan S. Tawfik, Haim Leader, Yaacov Ashani, Izhack Cherny, Moshe Goldsmith, Per Jr. Greisen, Sagar D. Khare, Gustav Oberdorfer, David Baker, Sarel Fleishman, Adi Goldenzweig, Nidhi Aggarwal
  • ISOLATED PHOSPHOTRIESTERASE POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF IN TREATING OR PREVENTING ORGANOPHOSPHATE EXPOSURE ASSOCIATED DAMAGE
    Publication number: 20190083836
    Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.
    Type: Application
    Filed: December 10, 2015
    Publication date: March 21, 2019
    Inventors: Dan S. TAWFIK, Haim LEADER, Yaacov ASHANI, Izhack CHERNY, Moshe GOLDSMITH, Per Jr. GRIESEN, Sagar D KHARE, Gustav Oberdorfer, David Baker, Sarel Fleishman, Adi Goldenzweig, Nidhi Aggarwal
  • Carbaphens: aprophen analogs that are binary antidotes for organophosphate poisoning
    Patent number: 5026897
    Abstract: Novel carbaphens are provided of the formula ##STR1## wherein R is OH, OCON(CH.sub.3).sub.2 or OCONHCH.sub.3, and R' is H, OH or sub.2 OCON(CH.sub.3).sub.2, stereoisomers thereof, pharmaceutically-acceptable salts thereof or mixtures thereof.Compositions comprise the carbaphens with pharmaceutically acceptable carriers, and they may further comprise other drugs as well.Methods of treating patients either prophylactically or therapeutically which suffer from organophosphate poisoning, coronary insufficiency, cerebral vasospasms, spastic cholitis and cholecystitis comprise the administration of the carbaphens of the invention.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: June 25, 1991
    Assignee: The United States of America, as represented by the Secretary of the Army
    Inventors: Peter K. Chiang, Haim Leader, Ruthann M. Smejkal, Richard K. Gordon, Charlotte S. Payne, Bhupendra P. Doctor, Felipe N. Padilla
  • Carbaphens: aprophen analogs that are binary antidotes for organophosphate poisoning
    Patent number: 4973734
    Abstract: Novel carbaphens are provided of the formula ##STR1## wherein R is OH, OCON(CH.sub.3).sub.2 or OCONHCH.sub.3, and R' is H, OH or .sub.2 OCON(CH.sub.3).sub.2, stereoisomers thereof, pharmaceutically-acceptable salts thereof or mixtures thereof.Compositions comprise the carbaphens with pharmaceutically acceptable carriers, and they may further comprise other drugs as well.Methods of treating patients either prophylactically or therapeutically which suffer from organophosphate poisoning, coronary insufficiency, cerebral vasospasms, spastic cholitis and cholecystitis comprise the administration of the carbaphens of the invention.
    Type: Grant
    Filed: March 17, 1989
    Date of Patent: November 27, 1990
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Peter K. Chiang, Haim Leader, Ruthann M. Smeikal, Richard K. Gordon, Charlotte S. Payne, Bhupendra P. Doctor, Felipe N. Padilla
  • Dioxaphosphorinanes
    Patent number: 4472320
    Abstract: There are provided dioxaphosphorinane compounds, a process for the production of these and compositions containing same. These are non-toxic anticholinesterase drugs for the treatment of organophosphorus poisoning, and for the treatment of cholinergic diseases.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: September 18, 1984
    Inventors: Yacov Ashani, Haim Leader, Lily Raveh, Rachel Bruckstein, Michael Spiegelstein