Patents by Inventor Haim Moskowitz
Haim Moskowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240358844Abstract: The present invention is related to a drug delivery composition that includes a thioredoxin homologue protein having an N-terminal monocysteinic active site, with the cysteine residue of the active site in a reduced state and an active agent conjugated to the thioredoxin homologue protein and methods of making and using the composition.Type: ApplicationFiled: June 4, 2024Publication date: October 31, 2024Applicant: ORPRO THERAPEUTICS, INC.Inventors: Peter B. HEIFETZ, Haim MOSKOWITZ
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Publication number: 20230071765Abstract: The present disclosure relates to preparations, formulations and uses of a protein or peptide having thioredoxin action for treating diseases and/or conditions. One aspect of the invention is a method to decrease viscoelasticity of mucus or sputum in a patient that has excessively viscous or cohesive mucus or sputum. The method includes contacting the mucus or sputum of the patient with a composition comprising a protein or peptide comprising a thioredoxin monocysteinic active site, wherein the protein or peptide does not contain any cysteine residues except for a single Cys at the N-terminal position of the thioredoxin monocysteinic active site.Type: ApplicationFiled: January 4, 2021Publication date: March 9, 2023Inventors: Peter B. Heifetz, Haim Moskowitz
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Publication number: 20210213134Abstract: The present invention is related to a drug delivery composition that includes a thioredoxin homologue protein having an N-terminal monocysteinic active site, with the cysteine residue of the active site in a reduced state and an active agent conjugated to the thioredoxin homologue protein and methods of making and using the composition.Type: ApplicationFiled: May 17, 2019Publication date: July 15, 2021Inventors: Peter B. HEIFETZ, Haim MOSKOWITZ
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Publication number: 20190070251Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.Type: ApplicationFiled: April 28, 2017Publication date: March 7, 2019Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
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Patent number: 9763995Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.Type: GrantFiled: August 7, 2015Date of Patent: September 19, 2017Assignee: Nektar TherapeuticsInventors: Yujun Wang, Haim Moskowitz, Xiaofeng Liu, Steven O. Roczniak, Mary J. Bossard
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Patent number: 9682153Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.Type: GrantFiled: March 20, 2015Date of Patent: June 20, 2017Assignee: Nektar TherapeuticsInventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
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Publication number: 20160158311Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.Type: ApplicationFiled: August 7, 2015Publication date: June 9, 2016Inventors: Yujun Wang, Haim Moskowitz, Xiaofeng Liu, Steven O. Roczniak, Mary J. Bossard
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Publication number: 20160022828Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.Type: ApplicationFiled: March 20, 2015Publication date: January 28, 2016Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
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Patent number: 9163227Abstract: The present invention provides a composition of the formula: [FGF21-1st Linker]-[Ab]-[2nd-Linker-Ex4]; wherein FGF21 is an FGF21 homologue; and Ex4 is an Exendin4 homologue; and Ab is an aldolase catalytic antibody or antigen binding portion thereof; and the 1st linker is covalently attached to the side chain of a protein-linking residue in FGF21 and to a combining site of the antibody, and the 2nd linker is covalently attached to the side chain of a peptide-linking residue in Ex4 and to a combining site of the antibody, and wherein the first and second linker are the same or different. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.Type: GrantFiled: December 12, 2012Date of Patent: October 20, 2015Assignee: COVX TECHNOLOGIES IRELAND LIMITEDInventors: Gopinath Vedachalam Annathur, Palani Balu, Rory Francis Finn, Jie Huang, Olivier Alexandre Laurent, Nancy Jane Levin, Nicholas Gary Luksha, Joseph Patrick Martin, Jr., Haim Moskowitz, Moorthy Sitharamaiah Suriyanarayana Palanki, Mark John Pozzo, Gregory Allan Waszak, Jin Xie
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Publication number: 20110171161Abstract: The invention provides protegrin that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention has enhanced half-life and/or reduced clearance.Type: ApplicationFiled: September 17, 2009Publication date: July 14, 2011Applicant: Nektar TherapeuticsInventors: Yujun Wang, Haim Moskowitz, Xiaofeng Liu, Steven O. Roczniak, Mary J. Bossard
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Publication number: 20110166063Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.Type: ApplicationFiled: September 17, 2009Publication date: July 7, 2011Applicant: Nektar TherapeuticsInventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
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Publication number: 20110165112Abstract: The invention provides pro insulin c-peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.Type: ApplicationFiled: September 17, 2009Publication date: July 7, 2011Applicant: Nektar TherapeuticsInventors: Mary J. Bossard, Dennis G. Fry, Steven O. Roczniak, Cherie F. Ali, Haim Moskowitz
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Publication number: 20110165113Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.Type: ApplicationFiled: September 17, 2009Publication date: July 7, 2011Applicant: Nektar TherapeuticsInventors: Steven O. Roczniak, Ping Zhang, Haim Moskowitz
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Publication number: 20050181355Abstract: This application describes a family of nucleic acid sequences and proteins encoded thereby that play a role in viral maturation: the Alternate Viral Maturation Scaffolding Protein, or the AVMSP family of proteins.Type: ApplicationFiled: July 31, 2002Publication date: August 18, 2005Inventors: Tsvika Greener, Haim Moskowitz, Yuval Reiss, Iris Alroy
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Publication number: 20050158708Abstract: This invention relates to methods and reagents for selectively labeling membrane surface proteins using a labeling agent. The label may be used to isolate preparations of membrane surface proteins. Preparations of membrane surface proteins may be analysed by a variety of high-throughput techniques to allow rapid profiling of membrane surface protein composition.Type: ApplicationFiled: June 6, 2002Publication date: July 21, 2005Inventors: Iris Alroy, Haim Moskowitz, Yuval Reiss, Benjamin Shoham
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Publication number: 20030049607Abstract: This application describes a family of nucleic acid sequences and proteins encoded thereby that play a role in viral maturation: the Viral Maturation Scaffolding Protein, or the VMSP family of proteins.Type: ApplicationFiled: March 12, 2002Publication date: March 13, 2003Inventors: Tsvika Greener, Haim Moskowitz, Yuval Reiss, Iris Alroy
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Patent number: 6475763Abstract: Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.Type: GrantFiled: January 19, 2000Date of Patent: November 5, 2002Assignee: Insight Strategy & Marketing Ltd.Inventors: Maty Ayal-Hershkovitz, Haim Moskowitz, Daphna Miron, Ayelet Gilboa, Madlene Mimon, Hanna Ben-Artzi, Oron Yacoby-Zeevi, Iris Pecker, Yoav Peleg, Yinon Shlomi
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Patent number: 6348344Abstract: Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.Type: GrantFiled: March 2, 1999Date of Patent: February 19, 2002Assignee: Insight Strategy & Marketing Ltd.Inventors: Maty Ayal-Hershkovitz, Haim Moskowitz, Daphna Miron, Ayelet Gilboa, Madelene Mimon, Hanna Ben-Artzi, Oron Yacoby-Zeevi, Iris Pecker, Yoav Peleg, Yinon Schlomi
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Patent number: 6162430Abstract: A method is provided that accelerates the rate of kill of pests such as from the order Lepidoptera. The method comprises treating the pests or their loci with at least two different insect toxins which are expressed from at least one recombinant microbe. Pairs of toxins that do not compete with each other on the same binding site and that differ in their pharmacology have been found to provide synergistic control. Preferred insecticidal microbes are baculoviruses.Type: GrantFiled: February 6, 1998Date of Patent: December 19, 2000Assignee: The Regents of the University of CaliforniaInventors: Bruce D. Hammock, Rafael Herrmann, Haim Moskowitz
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Patent number: 5756340Abstract: A method is provided that accelerates the rate of kill of pests such as from the order Lepidoptera. The method comprises treating the pests or their loci with at least two different insect toxins which are expressed from at least one recombinant microbe. Pairs of toxins that do not compete with each other on the same binding site and that differ in their pharmacology have been found to provide synergistic control. Preferred insecticidal microbes are baculoviruses.Type: GrantFiled: May 8, 1995Date of Patent: May 26, 1998Assignee: The Regents of the University of CaliforniaInventors: Bruce D. Hammock, Rafael Herrmann, Haim Moskowitz