Patents by Inventor Haimanti Dorai

Haimanti Dorai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection of human umbilical cord tissue-derived cells
    Patent number: 10724105
    Abstract: The invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hUTC)) in blood. The methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hUTC) and one or more markers positive for human peripheral blood mononuclear cells (PBMC); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hUTC), analyzing the sample using an assay method to detect one or more markers positive for PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC); and distinguishing between the PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC). In one embodiment, the cells are hUTC and the markers positive of hUTC include CD10 and/or CD13 and the one or more markers positive for PBMC includes CD45.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: July 28, 2020
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Haimanti Dorai, Reyna L. Favis, Xiang Yao, Yu Sun, Anthony J. Kihm, Stefanie Rassnick
  • DETECTION OF HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS
    Publication number: 20170335409
    Abstract: The invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hUTC)) in blood. The methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hUTC) and one or more markers positive for human peripheral blood mononuclear cells (PBMC); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hUTC), analyzing the sample using an assay method to detect one or more markers positive for PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC); and distinguishing between the PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC). In one embodiment, the cells are hUTC and the markers positive of hUTC include CD10 and/or CD13 and the one or more markers positive for PBMC includes CD45.
    Type: Application
    Filed: March 31, 2017
    Publication date: November 23, 2017
    Applicant: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Haimanti Dorai, Reyna L. Favis, Xiang Yao, Yu Sun, Anthony J. Kihm, Stefanie Rassnick
  • Detection of human umbilical cord tissue derived cells
    Patent number: 9611513
    Abstract: The invention relates to methods for detecting allogeneic therapeutic cells (such as human umbilical cord tissue-derived cells (hUTC)) in blood. The methods includes the steps of identifying one or more one or more markers positive for allogeneic therapeutic cells (e.g. hUTC) and one or more markers positive for human peripheral blood mononuclear cells (PBMC); providing a blood sample from a patient that has been treated with allogeneic therapeutic cells (e.g. hUTC), analyzing the sample using an assay method to detect one or more markers positive for PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC); and distinguishing between the PBMC and one or more markers positive for allogeneic therapeutic cells (e.g. hUTC). In one embodiment, the cells are hUTC and the markers positive of hUTC include CD10 and/or CD13 and the one or more markers positive for PBMC includes CD45.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: April 4, 2017
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Haimanti Dorai, Reyna L. Favis, Xiang Yao, Yu Sun, Anthony J. Kihm, Stefanie Rassnick
  • Methods for improving viability and productivity in cell culture
    Patent number: 8492144
    Abstract: Methods for increasing viability and production of secreted proteins in fed batch eukaryotic cell culture are disclosed.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: July 23, 2013
    Assignee: Janssen Biotech, Inc.
    Inventors: Haimanti Dorai, Celia Ly, Tina M. Sauerwald McClain
  • Methods for Improving Viability and Productivity in Cell Culture
    Publication number: 20120003735
    Abstract: Methods for increasing viability and production of secreted proteins in fed batch eukaryotic cell culture are disclosed.
    Type: Application
    Filed: September 14, 2011
    Publication date: January 5, 2012
    Inventors: Haimanti Dorai, Celia Ly, Tina M. Sauerwald McClain
  • Selection of high-producing cell lines
    Patent number: 8017325
    Abstract: The invention describes a method for screening antibody producing cell lines for selection of high expressing clones.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: September 13, 2011
    Assignee: Centocor Ortho Biotech Inc.
    Inventor: Haimanti Dorai
  • Human OCT-2 variant peptide chains, nucleic acids, and methods
    Patent number: 7888117
    Abstract: Homo sapiens OCT-2 variant peptide chains are disclosed. Polynucleotides encoding these peptide chains, cells comprising these polynucleotides, and methods of using the forgoing are also disclosed.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: February 15, 2011
    Inventors: Haimanti Dorai, Jin Lu
  • BMP-7 variant compositions, methods and uses
    Patent number: 7659250
    Abstract: Human Bone Morphogenic Protein 7 (hBMP-7) variant peptide chains, nucleic acids encoding these peptide chains, and methods of making and using the foregoing are disclosed.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: February 9, 2010
    Assignee: Centocor, Inc.
    Inventors: Bernard Amegadzie, Mark Cunningham, Haimanti Dorai, Jeffrey Luo, Juliane Mills, Bethany Swencki-Underwood
  • Methods for Improving Viability and Productivity in Cell Culture
    Publication number: 20100028942
    Abstract: Methods for increasing viability and production of secreted proteins in fed batch eukaryotic cell culture are disclosed.
    Type: Application
    Filed: June 12, 2009
    Publication date: February 4, 2010
    Inventor: Haimanti Dorai
  • Methods for Obtaining High Viable Cell Density in Mammalian Cell Culture
    Publication number: 20090325287
    Abstract: Methods for increasing viability in fed batch eukaryotic cell culture are disclosed.
    Type: Application
    Filed: June 12, 2009
    Publication date: December 31, 2009
    Inventors: Haimanti Dorai, Yun Seung Kyung
  • HOST CELL LINES FOR PRODUCTION OF ANTIBODY CONSTANT REGION WITH ENHANCED EFFECTOR FUNCTION
    Publication number: 20090214528
    Abstract: Host cell lines for biopharmaceutical production of antibodies, antibody fragments or antibody-derived fusion proteins are selected as having the capability of inducing improved cellular effector functions, e.g., Fc-medicated effector functions. The host cells are derived from the rat myeloma cell line YB2/0 and are adapted to growth in chemically-defined medium.
    Type: Application
    Filed: August 31, 2006
    Publication date: August 27, 2009
    Inventors: Haimanti Dorai, Yun Seung Kyung, Bernard Scallon
  • Selection of High-Producing Cell Lines
    Publication number: 20090191545
    Abstract: The invention describes a method for screening antibody producing cell lines for selection of high expressing clones.
    Type: Application
    Filed: January 28, 2008
    Publication date: July 30, 2009
    Inventor: Haimanti Dorai
  • Materials and methods to increase peptide chain expression
    Patent number: 7498150
    Abstract: DNA sequences that increase peptide chain expression when operably linked to a gene encoding the peptide chain and methods of generating a peptide chain expression host cell using the foregoing are disclosed. Peptide chain expression host cells are also disclosed.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: March 3, 2009
    Assignee: Centocor, Inc.
    Inventors: Pamela H. Nelson, Gordon Moore, Barry A. Morse, Haimanti Dorai, Bernard Scallon, Linda Hendricks
  • Materials and methods to increase peptide chain expression
    Publication number: 20080213829
    Abstract: DNA sequences that increase peptide chain expression when operably linked to a gene encoding the peptide chain and methods of generating a peptide chain expression host cell using the foregoing are disclosed. Peptide chain expression host cells are also disclosed.
    Type: Application
    Filed: August 11, 2006
    Publication date: September 4, 2008
    Inventors: Pamela H. Nelson, Gordon Moore, Barry A. Morse, Haimanti Dorai, Bernard Scallon, Linda Hendricks
  • BMP-7 Variant Compositions, Methods and Uses
    Publication number: 20080032919
    Abstract: Human Bone Morphogenic Protein 7 (hBMP-7) variant peptide chains, nucleic acids encoding these peptide chains, and methods of making and using the foregoing are disclosed.
    Type: Application
    Filed: June 8, 2007
    Publication date: February 7, 2008
    Inventors: Bernard Amegadzie, Mark Cunningham, Haimanti Dorai, Jeffrey Luo, Juliane Mills, Bethany Swencki-Underwood
  • Human OCT-2 Variant Peptide Chains, Nucleic Acids, and Methods
    Publication number: 20070292915
    Abstract: Homo sapiens OCT-2 variant peptide chains are disclosed. Polynucleotides encoding these peptide chains, cells comprising these polynucleotides, and methods of using the forgoing are also disclosed.
    Type: Application
    Filed: May 17, 2007
    Publication date: December 20, 2007
    Inventors: Haimanti Dorai, Jin Lu
  • Methods for protein production
    Publication number: 20050186187
    Abstract: Methods for altering the cellular secretion rate of a protein, such as an antibody and the altered cells produced by the method are disclosed. The methods and altered cells are useful for producing high levels of proteins for therapeutic, diagnostic or research purposes.
    Type: Application
    Filed: February 11, 2005
    Publication date: August 25, 2005
    Inventor: Haimanti Dorai
  • Methods and compositions for high protein production from non-native DNA
    Patent number: 5733782
    Abstract: Disclosed herein are improved methods and compositions for achieving enhanced protein production expressed from non-native gene constructs, including single chain sFv and derivative sequences. The methods and compositions are particularly useful for creating stably transfected, constitutively expressing immortalized mammalian cell lines that exhibit high recombinant protein productivity while maintaining a low copy number per cell of the non-native recombinant DNA sequence encoding the protein of interest.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 31, 1998
    Assignee: Creative BioMolecules, Inc.
    Inventors: Haimanti Dorai, Hermann Oppermann
  • Methods and compositions for high protein production form recombinant DNA
    Patent number: 5712119
    Abstract: Disclosed herein are improved methods and compositions for achieving enhanced protein production expressed from non-native gene constructs, including single chain sFv and derivative sequences. The methods and compositions are particularly useful for creating stably transfected, contitutively expressing immortalized mammalian cell lines that exhibit high recombinant protein productivity while maintaining a low copy number per cell of the non-native recombinant DNA sequence encoding the protein of interest.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: January 27, 1998
    Assignee: Creative BioMolecules, Inc.
    Inventors: Hermann Oppermann, Haimanti Dorai, Paul Kaplan
  • Methods and compositions for high protein production from non-native DNA
    Patent number: 5658763
    Abstract: Disclosed herein are improved methods and compositions for achieving enhanced protein production expressed from non-native gene constructs, including single chain sFv and derivative sequences. The methods and compositions are particularly useful for creating stably transfected, contitutively expressing immortalized mammalian cell lines that exhibit high recombinant protein productivity while maintaining a low copy number per cell of the non-native recombinant DNA sequence encoding the protein of interest.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 19, 1997
    Assignee: Creative BioMolecules, Inc.
    Inventors: Haimanti Dorai, Hermann Oppermann