Abstract: The invention generally provides improved compositions and methods for detecting, diagnosing, prognosing, and monitoring multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in a subject. In particular, the invention provides methods for detecting BCMA in subjects to reliably diagnose, predict survival, or monitor multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in the subject.

Abstract: A poly(phenylene ether)-based composition exhibiting improved resistance to decomposition after repeated exposure to high voltages is prepared by melt-blending specific amounts of a poly(phenylene ether), an organophosphate ester flame retardant, and a surface energy reducing agent. The composition includes no more than 30 weight percent of mineral filler. Also described is an injection molded article prepared from the composition.

Abstract: The invention relates to aqueous polymer dispersions comprising polymerized units issued from the following monomers with related weight proportions based on 100 parts of weight of a)+b): a) 50 to 90% of a monoethylenically unsaturated non-ionic monomer, b) 10 to 50% of vinyl aromatic monomer or methyl methacrylate, c) 1 to 5% of a hydroxy-containing (meth)acrylate, d) 0.1 to 3% of acid monomer selected from d1) acid monomer selected from monocarboxylic or dicarboxylic acid monomers and d2) acid monomer selected from phosphorous-based or sulfur-based strong acid monomers or/and their salts, or from the mixtures of d1) and d2), e) 0.001 to 0.5% of chain transfer agent, and f) 0 to 1% one of internal crosslinker bearing at least two copolymerisable ethylenic unsaturations, the polymer having a Tg measured by DSC from ?30 to 0° C. and a gel content of 0 to 60%, formed during polymerization.

Abstract: The present invention provides a supramolecular hot melt adhesive. The present application also provides a method for preparing a supramolecular hot melt adhesive, comprising the steps of: A) dissolving a diol oligomer or diamine oligomer in a solvent, and reacting the mixture with diisocyanate under the action of a catalyst to obtain an initial reactant; B) mixing 2-amino-4-hydroxyl-6-methylpyrimidine, the initial reactant and a solvent for reaction; C) reacting the reactant obtained in step B) with a multifunctional crosslinking agent to obtain the supramolecular hot melt adhesive. The preparation method of the present invention constructs a supramolecular material with excellent strength, toughness and self-healing ability by a synergistic effect of multiple hydrogen bonds between carbamate or ureido group and pyrimidine group.

Abstract: A reflective article includes an injection molded thermoplastic substrate, and a reflective metal layer disposed on a surface of the thermoplastic substrate. The injection molded thermoplastic substrate is prepared from a pre-blended composition including specific amounts of two poly(phenylene ether)s having different intrinsic viscosities, an atactic polystyrene, and, optionally, a hydrogenated block copolymer of an alkenyl aromatic compound and a conjugated diene. The reflective article is lighter and less costly than comparable reflective articles based on heat-resistant polycarbonates. Also described are a melt-blended composition derived from the pre-blended composition, and an injection-molded article prepared from the melt-blended composition.

Abstract: The present invention provides a method for preparing a thermoplastic elastomer with excellent resilience and high strength, comprising the steps of: A) adding at least two soft segment monomers into a solvent, and then adding a hard segment monomer to the mixture for reaction under the action of a catalyst to obtain an initial reactant; B) subjecting the initial reactant to react with a chain extending agent to obtain a thermoplastic elastomer. In the thermoplastic elastomer provided by the present application, the multiple hydrogen bonds in the hard segment monomer provide it with high strength and high modulus, and the thermodynamic incompatibility of the soft segment monomers provides it with excellent toughness and high resilience. Therefore, the thermoplastic elastomer provided by the present application has advantages of excellent strength, toughness, rapid resilience and high resilience rate.

Abstract: The invention relates to aqueous polymer dispersions comprising polymerized units issued from the following monomers with related weight proportions based on 100 parts of weight of a)+b): a) 50 to 90% of a monoethylenically unsaturated non-ionic monomer, b) 10 to 50% of vinyl aromatic monomer or methyl methacrylate, c) 1 to 5% of a hydroxy-containing (meth)acrylate, d) 0.1 to 3% of acid monomer selected from d1) acid monomer selected from monocarboxylic or dicarboxylic acid monomers and d2) acid monomer selected from phosphorous-based or sulfur-based strong acid monomers or/and their salts, or from the mixtures of d1) and d2), e) 0.001 to 0.5% of chain transfer agent, and f) 0 to 1% one of internal crosslinker bearing at least two copolymerisable ethylenic unsaturations, the polymer having a Tg measured by DSC from ?30 to 0° C. and a gel content of 0 to 60%, formed during polymerization.

Abstract: A thermoplastic composition comprises particular amounts of a poly(phenylene ether)-poly(siloxane) block copolymer reaction product; a hydrogenated block copolymer of an alkenyl aromatic and a conjugated diene; tricalcium phosphate; and an organophosphate ester flame retardant. The composition can be particularly useful for use in battery pack insulation films or sheets.

Abstract: A package arrangement comprising a structure formed by a plurality of layers including an outer layer formed of a polymer material, one or more interior layers formed of a semi-aromatic polyamide composite material, and an inner layer formed of a polymer material, and an amount of water contained within the structure, the water including an amount of ozone dissolved therein, wherein the interior layer of the structure is configured to absorb oxygen and induce the degradation of the ozone.

Abstract: The present invention provides methods of treating and/or inhibiting cancer by administering a JAK1/2 inhibitor (e.g., ruxolitinib). The JAK1/2 inhibitor decreases expression of (or inhibits increased expression of) the checkpoint proteins PD-1, PD-L1, PD-L2, or B7 H3, and/or enhances T-cell killing of tumor cells, and/or enhances the anti-tumor effects of checkpoint inhibitors. The disclosed methods improve the efficacy of immune-based therapies used in treatment of cancer.

Abstract: A package arrangement comprising a structure formed by a plurality of layers including an outer layer formed of a polymer material, one or more interior layers formed of a semi-aromatic polyamide composite material, and an inner layer formed of a polymer material, and an amount of water contained within the structure, the water including an amount of ozone dissolved therein, wherein the interior layer of the structure is configured to absorb oxygen and induce the degradation of the ozone.

Abstract: The invention relates to aqueous polymer dispersions comprising polymerized units issued from the following monomers with related weight proportions based on 100 parts of weight of a)+b): a) 50 to 90% of a monoethylenically unsaturated non-ionic monomer, b) 10 to 50% of vinyl aromatic monomer or methyl methacrylate, c) 1 to 5% of a hydroxy-containing (meth)acrylate, d) 0.1 to 3% of acid monomer selected from d1) acid monomer selected from monocarboxylic or dicarboxylic acid monomers and d2) acid monomer selected from phosphorous-based or sulfur-based strong acid monomers or/and their salts, or from the mixtures of d1) and d2), e) 0.001 to 0.5% of chain transfer agent, and f) 0 to 1% one of internal crosslinker bearing at least two copolymerisable ethylenic unsaturations, the polymer having a Tg measured by DSC from ?30 to 0° C. and a gel content of 0 to 60%, formed during polymerization.

Abstract: The invention generally provides improved compositions and methods for detecting, diagnosing, prognosing, and monitoring multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in a subject. In particular, the invention provides methods for detecting BCMA in subjects to reliably diagnose, predict survival, or monitor multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in the subject.

Abstract: The invention generally provides improved compositions and methods for detecting, diagnosing, prognosing, and monitoring multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in a subject. In particular, the invention provides methods for detecting BCMA in subjects to reliably diagnose, predict survival, or monitor multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in the subject.

Abstract: Polyamide base resins with improved crystallization dynamics for the production of reinforced polyamide compositions having improved surface, shrink, warpage and mechanical properties such as toughness. The polyamide base resins are copolymers of polyamide 6 and polyamide 66, formed of ratios that are tailored to reduce the crystallization rate and final crystallization extent when used in melt processing to produce glass filled articles. The copolymers demonstrate improved polyamide morphology dynamics that in turn impart improved final properties in reinforced molded articles, such as improved surface finish, improved toughness/impact resistance, reduced warpage, and more symmetrical shrinkage properties.

Abstract: The invention generally provides improved compositions and methods for detecting, diagnosing, prognosing, and monitoring multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in a subject. In particular, the invention provides methods for detecting BCMA in subjects to reliably diagnose, predict survival, or monitor multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in the subject.

Abstract: This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages, wherein the cancer is relates to multiple myeloma, including multiple myeloma precursor diseases. This invention further relates to extracellular domains of TMEM154 proteins and variants, and therapeutic usages thereof.