Patents by Inventor Hainan Chen

Hainan Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene editing method using virus
    Patent number: 11597947
    Abstract: Provided is a method of inserting a polynucleotide sequence into a genome of a cell. The method comprises: generating a double-strand break at a target site of the genome; and introducing into the cell a virus. The virus comprises a nucleic acid comprising the polynucleotide sequence to be inserted or the complementary sequence thereof. The nucleic acid does not comprise a homologous arm or comprises very short (5˜25 bp) homologous arms corresponding to the target site. Also provided herein is a composition for inserting a polynucleotide sequence into a genome of a cell. The composition comprises a site-specific nuclease capable of generating a DNA double-strand break at a target site of the genome and a virus comprising a nucleic acid comprising the polynucleotide sequence or the complementary sequence thereof.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 7, 2023
    Assignee: ASC THERAPEUTICS INC.
    Inventors: Ling-Jie Kong, Mi Shi, Hainan Chen, Ruby Yanru Tsai
  • GENE EDITING METHOD USING VIRUS
    Publication number: 20210198696
    Abstract: Provided is a method of inserting a polynucleotide sequence into a genome of a cell. The method comprises: generating a double-strand break at a target site of the genome; and introducing into the cell a virus. The virus comprises a nucleic acid comprising the polynucleotide sequence to be inserted or the complementary sequence thereof. The nucleic acid does not comprise a homologous arm or comprises very short (5˜25 bp) homologous arms corresponding to the target site. Also provided herein is a composition for inserting a polynucleotide sequence into a genome of a cell. The composition comprises a site-specific nuclease capable of generating a DNA double-strand break at a target site of the genome and a virus comprising a nucleic acid comprising the polynucleotide sequence or the complementary sequence thereof.
    Type: Application
    Filed: December 29, 2017
    Publication date: July 1, 2021
    Inventors: Ling-jie KONG, Mi SHI, Hainan CHEN, Ruby Yanru TSAI
  • Methods and Compositions for Modulating Beta Cell Proliferation
    Publication number: 20150174202
    Abstract: Methods and compositions are provided for modulating pancreatic islet ? cell proliferation. Aspects of the methods include promoting ? cell proliferation by providing agents that promote PDGFR signaling, or inhibiting ? cell proliferation by providing agents that inhibit PDGFR signaling. These methods find a number of uses, including, for example, in the treatment of diabetes and human islet diseases. Also provided are reagents and kits thereof that find use in practicing the subject methods.
    Type: Application
    Filed: September 27, 2012
    Publication date: June 25, 2015
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hainan Chen, Seung K. Kim