Abstract: The present invention belongs to the field of biomedicine and relates to use of VCP (valosin-containing protein, VCP) inhibitor and oncolytic virus in the preparation of an anti-tumor drug. The present invention firstly discovers that VCP inhibitor can be used in the preparation of an anti-tumor synergist for oncolytic virus. Meanwhile, the present invention relates to a pharmaceutical composition comprising VCP inhibitor and oncolytic virus, a pharmaceutical kit comprising VCP inhibitor and oncolytic virus, and use of VCP inhibitor and oncolytic virus for treating tumor, especially a tumor that is not sensitive to oncolytic virus. The present invention also relates to an anti-tumor administration system, characterized in that, comprising oncolytic virus and a reagent for detecting the expression level of VCP.

Abstract: Described herein is use of a Caspase activator and an oncolytic virus in the preparation of an anti-tumor drug. As described, Caspase activator can enhance the anti-tumor effect of oncolytic virus, and the combination of Caspase activator and oncolytic virus produces a significant synergistic anti-tumor effect, and demonstrates an effective therapy for the treatment of tumors that are less sensitive to other pharmaceutical treatments.

Abstract: Disclosed is use of alphavirus in preparation of antitumor drugs. The alphavirus is M1 virus or Getah virus. In addition, the specific tumor types sensitive to abovementioned alphavirus treatment are further determined, so as to provide a safe and effective solution for antitumor drug administering schemes.

Abstract: The disclosure provides a method and device for switching an operating mode of a remote controller so as to address the problem in the prior art of inconvenient operations of switching the mode of the remote controller to thereby improve the experience of a user. The method for switching an operating mode of a remote controller includes: receiving a first pairing instruction transmitted by a first remote controller in an infrared mode, wherein the first pairing instruction carries the first device identifier of the first remote controller; searching a list of stored device identifiers to determine whether the first device identifier is present in the list; if so, then performing a pairing flow, and the remote controller is switched to the radio mode after a successful paring; otherwise, rejecting the first pairing instruction.

Abstract: Expanded beam (EB) connector includes a fiber holder having an alignment channel that is configured to receive an optical fiber. The alignment channel has a channel opening and extends from the channel opening to a channel end face. The EB connector also includes an optical substrate having a three-dimensional (3D) waveguide that includes a waveguide core and a cladding. The optical substrate includes the channel end face. The waveguide core extends lengthwise between first and second coupling faces of the waveguide core. The first coupling face is at least a portion of the channel end face. The first coupling face is configured to optically couple to the optical fiber disposed within the alignment channel. The second coupling face defines an exterior of the optical substrate. The waveguide core is shaped to change a mode field diameter and a numerical aperture of light propagating between the first and second coupling faces.

Abstract: An electrochromic test port provides an actively tunable system for building an optical test port for an optical waveguide with enhanced SNR properties over conventional approaches.

Abstract: Expanded beam (EB) connector includes a fiber holder having an alignment channel that is configured to receive an optical fiber. The alignment channel has a channel opening and extends from the channel opening to a channel end face. The EB connector also includes an optical substrate having a three-dimensional (3D) waveguide that includes a waveguide core and a cladding. The optical substrate includes the channel end face. The waveguide core extends lengthwise between first and second coupling faces of the waveguide core. The first coupling face is at least a portion of the channel end face. The first coupling face is configured to optically couple to the optical fiber disposed within the alignment channel. The second coupling face defines an exterior of the optical substrate. The waveguide core is shaped to change a mode field diameter and a numerical aperture of light propagating between the first and second coupling faces.

Abstract: A drive control apparatus includes a controller which controls a drive unit based on a voltage instruction signal obtained from a target signal and an abnormality detection unit which obtains the voltage instruction signal M times in a detection time period. The abnormality detection unit detects occurrence of an abnormality in response to detecting that the voltage instruction signal is outside predetermined range N times in the detection time period, where M is equal to or more than 2 and N is equal to or more than 1 and N is less than M.

Abstract: One aspect of the invention provides an optoelectronics structure including: a substrate defining a trench on a first surface; and a VCSEL structure mounted vertically within the trench of the substrate such that the VCSEL structure emits a laser beam substantially parallel to the substrate. Another aspect of the invention provides an optoelectronics structure including: an fiber guiding substrate defining a trench on a first surface; a VCSEL structure mounted vertically within the trench of the fiber guiding substrate such that the VCSEL structure emits a laser beam substantially parallel to the substrate; and an optical fiber mounted on the fiber guiding substrate substantially coaxial with the laser beam emitted by the VCSEL structure.

Abstract: One aspect of the invention provides a method of fabricating a mode size converter. The method includes: exposing a photoresist-coated substrate to varying doses of light exposure to produce a profile in the photoresist of a beam mode size converter; and etching the photoresist-coated substrate to remove an equal thickness of the photoresist and substrate. The beam mode sized converter includes: a first surface having a first surface height and a first surface width; a second surface opposite the first surface, the second surface having a second surface height different than the first surface height and a second surface width different than the first surface width; and one or more boundary surfaces connecting the first surface and second surfaces.

Abstract: One aspect of the invention provides a mode size converter having a first end and a second end. The mode size converter includes: a silicon waveguide having an inverse taper from the first end; and a silicon nitride waveguide having an inverse taper relative to the first end. The silicon nitride waveguide is adjacent and substantially parallel to the silicon waveguide. Another aspect of the invention provides an optical assembly including: a mode size converter as described herein; and a fiber optic optically coupled to the silicon nitride waveguide at the second end of the mode size converter.

Abstract: One aspect of the invention provides a method of fabricating a mode size converter. The method includes: exposing a photoresist-coated substrate to varying doses of light exposure to produce a profile in the photoresist of a beam mode size converter; and etching the photoresist-coated substrate to remove an equal thickness of the photoresist and substrate. The beam mode sized converter includes: a first surface having a first surface height and a first surface width; a second surface opposite the first surface, the second surface having a second surface height different than the first surface height and a second surface width different than the first surface width; and one or more boundary surfaces connecting the first surface and second surfaces.

Abstract: One aspect of the invention provides an optoelectronics structure including: a substrate defining a trench on a first surface; and a VCSEL structure mounted vertically within the trench of the substrate such that the VCSEL structure emits a laser beam substantially parallel to the substrate. Another aspect of the invention provides an optoelectronics structure including: an fiber guiding substrate defining a trench on a first surface; a VCSEL structure mounted vertically within the trench of the fiber guiding substrate such that the VCSEL structure emits a laser beam substantially parallel to the substrate; and an optical fiber mounted on the fiber guiding substrate substantially coaxial with the laser beam emitted by the VCSEL structure.

Abstract: An optical assembly comprising: (a) a substrate having a first planar surface; (b) an optical component connected to the substrate and having a second planar surface parallel to the first surface and at least one first optical axis; (c) a plurality of optical fiber stubs having a certain diameter and being disposed at least partially between the substrate and the optical component; (d) at least one of the substrate or the optical component having one or more grooves on the first or second surfaces, respectively, such that each groove is configured to receive one of the plurality of fiber stubs such that each of the fiber stubs protrudes a first distance from the first or second surface to space the first surface the first distance from the second surface; and (e) a least one optical conduit having a second optical axis, the optical conduit being disposed on the first or second surface such that the second optical axis is optically aligned with the first optical axis.

Abstract: Methods, systems, and computer readable media for social grouping are provided to perform social grouping of a user's contacts based on the user's interactions with the contacts. A set of attributes associated with interactions between a user and a set of contacts may be determined by a first device. The set of attributes associated with the interactions may be related to the first device. The set of contacts may be organized into a set of groups based on the set of attributes.

Abstract: A terahertz generation system that emits pulsed THz radiation and incorporates a rapidly oscillating, high voltage bias across electrodes insulated from a photoconductive material. The system includes an ultrafast optical pulse source configured to generate an optical pulse having a duration between about ten picoseconds and ten femtoseconds, the pulse further having a repetition rate of about one megahertz or higher. The system further includes a photoconductor configured to receive the optical pulse from the ultrafast optical pulse source and to generate a terahertz frequency pulse, the photoconductor having insulated electrodes. The system still further includes a radio frequency generator configured to apply an electric field to the photoconductor via the insulated electrodes.

Abstract: A terahertz generation system that emits pulsed THz radiation and incorporates a rapidly oscillating, high voltage bias across electrodes insulated from a photoconductive material. The system includes an ultrafast optical pulse source configured to generate an optical pulse having a duration between about ten picoseconds and ten femtoseconds, the pulse further having a repetition rate of about one megahertz or higher. The system further includes a photoconductor configured to receive the optical pulse from the ultrafast optical pulse source and to generate a terahertz frequency pulse, the photoconductor having insulated electrodes. The system still further includes a radio frequency generator configured to apply an electric field to the photoconductor via the insulated electrodes.