Abstract: The polymeric composition of this invention can be used as a temporary support material in the additive manufacturing of three dimensional articles without compromising ultimate product quality, reducing printing speed, requiring printers of increased complexity, or increasing cost or the incidence of printer jamming. This invention more specifically discloses a polymeric composition which is useful as a temporary support material for utilization in three-dimensional printing, this polymeric composition comprising of a first polymeric component which is suitable for use as a modeling material and a second polymeric component which is immiscible with the first polymeric component, wherein the polymeric composition has a continuous phase which is comprised of the second polymeric component, and wherein the polymeric composition has a Shore A hardness of at least 80.

Abstract: Compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

Abstract: The polymeric composition of this invention can be used as a temporary support material in the additive manufacturing of three dimensional articles without compromising the quality of the ultimate product, reducing printing speed, increasing cost, increasing the incidence of printer jamming, or requiring printers of increased complexity. This invention more specifically discloses a polymeric composition which is particularly useful as a temporary support material for utilization in three-dimensional printing, said polymeric composition being comprised of a first polymeric component which is suitable for use as a modeling material and a second polymeric component which is immiscible with the first polymeric component, wherein the polymeric composition has a continuous phase, wherein the continuous phase is comprised of the second polymeric component, and wherein the polymeric composition has a Shore A hardness of at least 80.

Abstract: This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

Abstract: A floating tunnel shore connecting system, a floating tunnel and a floating tunnel construction method are disclosed, where the design method of the floating tunnel is to apply axial tension along one end or two ends of a tube body respectively; The floating tunnel shore connecting system comprises a joint section located at the end of the tube body, which can move along the axial direction and is connected with a tension device for applying axial tension; The floating tunnel comprises a tube body and a hollow cavity, wherein the tube body comprises a floating section and a shore connecting system at two ends, and both joint sections are provided with tension devices.

Abstract: Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: The polymeric composition of this invention can be used as a temporary support material in the additive manufacturing of three dimensional articles without compromising the quality of the ultimate product, reducing printing speed, increasing cost, increasing the incidence of printer jamming, or requiring printers of increased complexity. This invention more specifically discloses a polymeric composition which is particularly useful as a temporary support material for utilization in three-dimensional printing, said polymeric composition being comprised of a first polymeric component which is suitable for use as a modeling material and a second polymeric component which is immiscible with the first polymeric component, wherein the polymeric composition has a continuous phase, wherein the continuous phase is comprised of the second polymeric component, and wherein the polymeric composition has a Shore A hardness of at least 80.

Abstract: The polymeric composition of this invention can be used as a temporary support material in the additive manufacturing of three dimensional articles without compromising the quality of the ultimate product, reducing printing speed, increasing cost, increasing the incidence of printer jamming, or requiring printers of increased complexity. This invention more specifically discloses a polymeric composition which is particularly useful as a temporary support material for utilization in three-dimensional printing, said polymeric composition being comprised of a first polymeric component which is suitable for use as a modeling material and a second polymeric component which is immiscible with the first polymeric component, wherein the polymeric composition has a continuous phase, wherein the continuous phase is comprised of the second polymeric component, and wherein the polymeric composition has a Shore A hardness of at least 80.

Abstract: The present application discloses a bearing structural member, a support, a joint assembly and a tube section assembly, wherein the maximum counter force provided by the bearing structural member under an external load is an own designed threshold value, namely when the external load is greater than the designed threshold value of the bearing structural member, the bearing structural member deforms, and provides a counter force equal to the designed threshold value; the support includes at least one bearing structural member; and the joint assembly and the tube section assembly are both equipped with the support. When the external load is not high and is less than the designed threshold value, the bearing structural member may effectively suppress the deformation just like a rigid structural member; when the external load exceeds the designed threshold value, the bearing structural member may deform, and provide a stable counter supporting force less than the external load.

Abstract: The polymeric composition of this invention can be used as a temporary support material in the additive manufacturing of three dimensional articles without compromising the quality of the ultimate product, reducing printing speed, increasing cost, increasing the incidence of printer jamming, or requiring printers of increased complexity. This invention more specifically discloses a polymeric composition which is particularly useful as a temporary support material for utilization in three-dimensional printing, said polymeric composition being comprised of a first polymeric component which is suitable for use as a modeling material and a second polymeric component which is immiscible with the first polymeric component, wherein the polymeric composition has a continuous phase, wherein the continuous phase is comprised of the second polymeric component, and wherein the polymeric composition has a Shore A hardness of at least 80.

Abstract: The present application discloses a prestressed tube section structure and a construction method thereof. The prestressed tube section structure includes multiple successively connected segments. A shear-resistant structure and a water stop system are arranged between two segments; multiple prestressing tendons are arranged in the tube section along the circumferential direction of the tube section; and each prestressing tendon is communicated along the longitudinal direction of the tube section, and is partitioned into multiple sections at a position close to a segment joint.

Abstract: The present application discloses a final joint of an immersed tunnel, a prefabrication method and an installation method, wherein the final joint includes two end surfaces connected with installed adjacent tube sections; the two end surfaces are both tilted surfaces, so that the longitudinal profile of the final joint along an installation direction is of an inverted trapezoid structure; and the final joint further may be of a structure with a tube section I and a tube section II which are connected with each other.

Abstract: This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

Abstract: This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: The present application discloses a bearing structural member, a support, a joint assembly and a tube section assembly, wherein the maximum counter force provided by the bearing structural member under an external load is an own designed threshold value, namely when the external load is greater than the designed threshold value of the bearing structural member, the bearing structural member deforms, and provides a counter force equal to the designed threshold value; the support includes at least one bearing structural member; and the joint assembly and the tube section assembly are both equipped with the support. When the external load is not high and is less than the designed threshold value, the bearing structural member may effectively suppress the deformation just like a rigid structural member; when the external load exceeds the designed threshold value, the bearing structural member may deform, and provide a stable counter supporting force less than the external load.

Abstract: The present application discloses a prestressed tube section structure and a construction method thereof. The prestressed tube section structure includes multiple successively connected segments. A shear-resistant structure and a water stop system are arranged between two segments; multiple prestressing tendons are arranged in the tube section along the circumferential direction of the tube section; and each prestressing tendon is communicated along the longitudinal direction of the tube section, and is partitioned into multiple sections at a position close to a segment joint.

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: The present application discloses a final joint of an immersed tunnel, a prefabrication method and an installation method, wherein the final joint includes two end surfaces connected with installed adjacent tube sections; the two end surfaces are both tilted surfaces, so that the longitudinal profile of the final joint along an installation direction is of an inverted trapezoid structure; and the final joint further may be of a structure with a tube section I and a tube section II which are connected with each other.