Patents by Inventor Hairuo Peng

Hairuo Peng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ATX MODULATING AGENTS
    Publication number: 20150210647
    Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
    Type: Application
    Filed: July 26, 2013
    Publication date: July 30, 2015
    Inventors: Kevin Guckian, Gnanasambandam Kumaravel, Bin Ma, Sha Mi, Hairuo Peng, Zhaohui Shao, Lihong Sun, Arthur Taveras, Deping Wang, Zhili Xin, Lei Zhang
  • COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS
    Publication number: 20150203515
    Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
    Type: Application
    Filed: July 26, 2013
    Publication date: July 23, 2015
    Inventors: Kevin Guckian, Gnanasambandam Kumaravel, Bin Ma, Sha Mi, Hairuo Peng, Zhaohui Shao, Lihong Sun, Arthur Taveras, Zhili Xin, Lei Zhang
  • COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
    Publication number: 20150080568
    Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Application
    Filed: July 28, 2014
    Publication date: March 19, 2015
    Inventors: Weirong Chen, Benjamin Lane, Hairuo Peng
  • Compounds useful as Raf kinase inhibitors
    Patent number: 8802657
    Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: August 12, 2014
    Assignees: Millennium Pharmaceuticals, Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Jennifer Cossrow, Bing Guan, John Howard Jones, Gnanasambandam Kumaravel, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • Compounds useful as Raf kinase inhibitors
    Patent number: 8293752
    Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: October 23, 2012
    Assignees: Millennium Pharmaceuticals, Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Weirong Chen, Jennifer Cossrow, Lloyd Franklin, Bing Guan, John Howard Jones, Gnanasambandam Kumaravel, Benjamin Lane, Adam Littke, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
    Publication number: 20120040951
    Abstract: The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Application
    Filed: December 30, 2009
    Publication date: February 16, 2012
    Inventors: Claudio Chuaqui, Jennifer Cossrow, James Dowling, Bing Guan, Michael Hoemann, Alexey Ishchenko, John Howard Jones, Lori Kabigting, Gnanasambandam Kumaravel, Hairuo Peng, Noel Powell, Brian Raimundo, Hiroko Tanaka, Kurt van Vloten, Jeffrey Vessels, Zhili Xin
  • Heterocyclic compounds useful as RAF kinase inhibitors
    Patent number: 7968536
    Abstract: The present invention provides compounds useful as inhibitors of protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: June 28, 2011
    Assignees: Millennium Pharmaceuticals, Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Jennifer Cossrow, Bing Guan, Alexey Ishchenko, John Howard Jones, Gnanasambandam Kumaravel, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • Aadenosine receptor antagonists
    Patent number: 7834014
    Abstract: The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I).
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: November 16, 2010
    Assignee: Biogen Idec MA Inc.
    Inventors: Hairuo Peng, Gang Yao, Russell C. Petter, Gnanasambandam Kumaravel
  • Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment
    Patent number: 7763620
    Abstract: The present invention relates to piperazinone compounds, pharmaceutical compositions containing those compounds and methods of treating tumors and cancer, among other disease states and conditions in mammalian patients, especially including humans.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: July 27, 2010
    Assignees: Yale University, University of South Florida
    Inventors: Andrew D. Hamilton, Said Sebti, Hairuo Peng
  • Triazolopyrazines and methods of making and using the same
    Patent number: 7674791
    Abstract: The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: March 9, 2010
    Assignee: Biogen IDEC MA Inc.
    Inventors: James E. Dowling, Gang Yao, Hexi Chang, Hairuo Peng, Jeffrey Vessels, Russell C. Petter, Gnanasambandam Kumaravel
  • COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
    Publication number: 20090036419
    Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Application
    Filed: June 30, 2008
    Publication date: February 5, 2009
    Applicant: Sunesis Pharmaceuticals, Inc.
    Inventors: Weirong Chen, Jennifer Cossrow, Lloyd Franklin, Bing Guan, John Howard Jones, Gnanasambandam Kumaravel, Benjamin Lane, Adam Littke, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • Heterocyclic Compounds Useful as RAF Kinase Inhibitors
    Publication number: 20090005359
    Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
    Type: Application
    Filed: June 30, 2008
    Publication date: January 1, 2009
    Applicant: Sunesis Pharmaceuticals, Inc
    Inventors: Jennifer Cossrow, Bing Guan, Alexey Ishchenko, John Howard Jones, Gnanasambandam Kumaravel, Alexey Lugovskoy, Hairuo Peng, Noel Powell, Brian C. Raimundo, Hiroko Tanaka, Jeffrey Vessels, Thomas Wynn, Zhili Xin
  • Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and Methods of Treatment
    Publication number: 20080221123
    Abstract: The present invention relates to piperazinone compounds, pharmaceutical compositions containing those compounds and methods of treating tumors and cancer, among other disease states and conditions in mammalian patients, especially including humans.
    Type: Application
    Filed: August 23, 2002
    Publication date: September 11, 2008
    Inventors: Andrew D. Hamilton, Said Sebti, Hairuo Peng
  • A2a adenosine receptor antagonists
    Publication number: 20070173505
    Abstract: The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula (I).
    Type: Application
    Filed: April 9, 2004
    Publication date: July 26, 2007
    Inventors: Hairuo Peng, Gang Yao, Russell Petter, Gnanasambandam Kumaravel
  • Triazolopyrazines and methods of making and using the same
    Publication number: 20070010520
    Abstract: The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease.
    Type: Application
    Filed: April 9, 2004
    Publication date: January 11, 2007
    Inventors: James Dowling, Gang Yao, Hexi Chang, Hairuo Peng, Jeffrey Vessels, Russell Petter, Gnanasambandam Kumaravel
  • Seco-cholestane derivatives and methods of making the same
    Patent number: 6011058
    Abstract: The present invention is directed to novel seco-cholestane derivatives, as well as to pharmaceutical compositions thereof, and methods of making the same. More particularly, the invention relates to C5- and C8-substituted seco-cholestane derivatives. The compounds of the invention can exhibit CDC25 phosphatase inhibition properties and anti-cancer activity.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: January 4, 2000
    Assignee: Georgia Tech Research Corporation
    Inventors: Leon H. Zalkow, Hairuo Peng