Patents by Inventor Haishan LUO

Haishan LUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250215100
    Abstract: Disclosed in the present invention are an antigen binding protein targeting CD40, and the preparation therefor and the use thereof. The antigen binding protein targeting CD40 has the characteristics of a high affinity to CD40 and a strong agonistic activity on signaling pathways, particularly the enhanced agonistic activity after crosslinking, so that the antigen binding protein targeting CD40 has a larger therapeutic window, and is expected to bring about new opportunities for the treatment of various tumors.
    Type: Application
    Filed: March 31, 2023
    Publication date: July 3, 2025
    Applicant: HARBOUR BIOMED (SHANGHAI) CO., LTD
    Inventors: Haishan LUO, He LI, Gang DENG, Yongqiang WANG, Yuandong WANG, Fei CHEN, Yiping RONG
  • Publication number: 20250215089
    Abstract: Disclosed are an antigen-binding protein targeting PD-L1 and CD40, preparation therefor, and use thereof. The antigen-binding protein targeting PD-L1 and CD40, by means of blocking a PD-1/PD-L1 inhibitory signaling pathway, acting on an activated CD40 receptor, and simultaneously activating an antigen-presenting cell and a lymphocyte, achieves a significant synergistic anti-tumor effect; meanwhile, the activation of the antigen-binding protein targeting PD-L1 and CD40 on an immune cell only occurs at a tumor microenvironment site, so that problems of systemic drug toxicity and side effects are significantly solved, which enables the antigen-binding protein targeting PD-L1 and CD40 to exert an excellent anti-tumor efficacy under very safe conditions.
    Type: Application
    Filed: March 31, 2023
    Publication date: July 3, 2025
    Applicant: HARBOUR BIOMED (SHANGHAI) CO., LTD
    Inventors: Haishan LUO, Zihong MENG, Jun RONG, Hongwei CHEN, Yuandong WANG, Yunxing YANG, Fei CHEN, Youhong WANG, Jia LU, Shutao LI, Gang DENG, Xin GAN, Yiping RONG
  • Publication number: 20250154268
    Abstract: Disclosed in the present invention is an antibody targeting CD25 or a variant thereof. A monoclonal antibody targeting CD25 is a naturally occurring antibody, has an activity of binding to human CD25 and cynomolgus monkey CD25, and has a stronger ADCC effect after being modified with Fc. In-vitro experiments show that the antibody has the effect of clearing Treg and lymphoma cells without blocking an IL-2 signaling pathway.
    Type: Application
    Filed: January 16, 2023
    Publication date: May 15, 2025
    Inventors: Qiuming PAN, Chengen WANG, Jinqiu HE, Yan LI, Yuandong WANG, Yongqiang WANG, Chuchu ZHAO, Hongjie PAN, Yiping RONG, Haishan LUO
  • Publication number: 20250052140
    Abstract: A method for performing a polymer flood of a hydrocarbon-bearing, subterranean reservoir (5) includes (a) injecting a polymer solution from an injection well (32) into the subterranean reservoir to form a polymer slug (44) in the subterranean reservoir, wherein the polymer slug has a leading front (46) and a trailing rear (48), and an S-shaped graded viscosity profile which decreases convexly in viscosity from the front of the polymer slug to an inflection point and concavely in viscosity from the inflection point to the rear of the polymer slug, (b) injecting an aqueous solution (50) from the injection well into the subterranean reservoir following (a) to displace the polymer slug through the subterranean reservoir.
    Type: Application
    Filed: December 21, 2022
    Publication date: February 13, 2025
    Applicant: TOTALENERGIES E&P RESEARCH & TECHNOLOGY USA, LLC
    Inventors: Stephane Jouenne, Alexandra Klimenko, Khalid Mateen, Kun Ma, Haishan Luo
  • Publication number: 20240269276
    Abstract: The present invention relates to a specific binding protein targeting PD-L1 and CD73, wherein the specific binding protein is capable of specifically binding to PD-L1 and/or a fragment thereof, and CD73 and/or a fragment thereof. The present invention further relates to use of the specific binding protein in the treatment, prevention and/or diagnosis of diseases such as immune diseases, acute and chronic inflammatory diseases, and tumor diseases.
    Type: Application
    Filed: May 24, 2022
    Publication date: August 15, 2024
    Inventors: Qianqian Shan, Xuekun Zhang, Xin Gan, Haishan Luo, Lei Shi, Yongqiang Wang, Xingxing Jia, Rongchao Wang, Yiping Rong
  • Publication number: 20240034792
    Abstract: Provided are an antigen binding protein capable of binding to PD-1 and a fusion protein thereof, and corresponding preparation method therefor and the use thereof. The fusion protein is capable of targeting PD-1 and CD73.
    Type: Application
    Filed: July 15, 2021
    Publication date: February 1, 2024
    Inventors: Haishan LUO, Qianqian SHAN, Yongqiang WANG, Xuekun ZHANG, Lei SHI, Yun ZHANG, Chuchu ZHAO, Wei ZHOU, Xin GAN
  • Publication number: 20230322953
    Abstract: Disclosed is a binding protein having at least two protein functional regions, the binding protein comprising a protein functional region A and a protein functional region B; the protein functional region A and the protein functional region B target different antigens or epitopes, the protein functional region A is a Fab or a scFv structure, the protein functional region B is a VH structure, and there are one or more of each of the protein functional region A and the protein functional region B. A multi-specific binding protein has a smaller molecular weight, fewer polypeptide chains, and a simpler structure. By means of different structure types, relative positions, binding valence and other parameters, the functional activities for different targets can be adjusted, and then different combinations of activities can be designed so as to meet the needs of different dose combinations of clinical combinations.
    Type: Application
    Filed: June 29, 2021
    Publication date: October 12, 2023
    Applicant: HARBOUR BIOMED (SHANGHAI) CO., LTD
    Inventors: Yun HE, Lei SHI, Haishan LUO, Qiang LV, Jinqiu HE, Zenglin PEI, Yongqiang WANG, Chen ZHONG, Bing HUANG, Jianxun ZHAO, Xingxing JIA, Xuekun ZHANG, Chuchu ZHAO, Fei CHEN, Lei NIU
  • Patent number: 10973915
    Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 13, 2021
    Assignee: SHANGHAI YUNYI HEALTHCARE AND TECHNOLOGY CO., LTD.
    Inventors: Lile Liu, Xinxiu Yang, Haishan Luo, Hu Liu, Zhengrong Shuai, Jian Wang, Qin Zhong, Qing Duan, Hongzhuan Gu, Tatchi Teddy Yang
  • Patent number: 10889648
    Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: January 12, 2021
    Assignee: JIANGSU HYAMAB PHARMACEUTICAL CO., LTD.
    Inventors: Lile Liu, Xinxiu Yang, Haishan Luo, Zhengrong Shuai, Hu Liu, Shaoping Hu, Xiaolan Sun, Hongzhuan Gu, Qing Duan, Tatchi Teddy Yang
  • Publication number: 20190010233
    Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.
    Type: Application
    Filed: December 27, 2016
    Publication date: January 10, 2019
    Inventors: Lile LIU, Xinxiu YANG, Haishan LUO, Zhengrong SHUAI, Hu LIU, Shaoping HU, Xiaolan SUN, Hongzhuan GU, Qing DUAN, Tatchi Teddy YANG
  • Publication number: 20180214548
    Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 2, 2018
    Inventors: Lile LIU, Xinxiu YANG, Haishan LUO, Hu LIU, Zhengrong SHUAI, Jian WANG, Qin ZHONG, Qing DUAN, Hongzhuan GU, Tatchi Teddy YANG