Abstract: Embodiments of the present disclosure include systems and methods for transposing matrices based on a multi-level crossbar. A system may include a memory configured to store a matrix comprising a plurality of elements arranged in a set of rows and a set of columns. A system may include an input buffer configured to retrieve a subset of a plurality of elements from the memory. Each element in the subset of the plurality of elements is retrieved from a different column in the matrix. A system may include a multi-level crossbar configured to perform a transpose operation on the subset of the plurality of elements. A system may include an output buffer configured to receive the transposed subset of the plurality of elements and store, in the memory, each element in the transposed subset of the plurality of elements in a different column in the matrix.

Abstract: A hardware retire circuit includes: one or more input queues, each queue corresponding to an input stream of tasks and being configured to store input task identifiers corresponding to tasks of the input stream; and processing logic configured to: receive a completed task event; determine whether a completed task queue identifier and a completed task identifier of the completed task event match an input task identifier of an input task at a head of an input queue having an input queue identifier corresponding to the completed task queue identifier; and in response to determining a match, pop the task at the head of the input queue and output a task retirement event corresponding to the input task.

Abstract: Provided are an antigen binding protein capable of binding to PD-1 and a fusion protein thereof, and corresponding preparation method therefor and the use thereof. The fusion protein is capable of targeting PD-1 and CD73.

Abstract: Disclosed is a binding protein having at least two protein functional regions, the binding protein comprising a protein functional region A and a protein functional region B; the protein functional region A and the protein functional region B target different antigens or epitopes, the protein functional region A is a Fab or a scFv structure, the protein functional region B is a VH structure, and there are one or more of each of the protein functional region A and the protein functional region B. A multi-specific binding protein has a smaller molecular weight, fewer polypeptide chains, and a simpler structure. By means of different structure types, relative positions, binding valence and other parameters, the functional activities for different targets can be adjusted, and then different combinations of activities can be designed so as to meet the needs of different dose combinations of clinical combinations.

Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.

Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.

Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.

Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.