Abstract: An industrial internet of things with independent management platform and control methods thereof are provided. The service platform and sensor network platform use a centralized arrangement, and the management platform uses an independent arrangement. When the management platform receives sensing detection data transmitted by the object platform, the sensing detection data is presented to the user platform after being processed by a sub-platform. When the management platform sends a control command to the object platform, a control parameter of a type of production line stage is calculated by a corresponding sub-platform and sent to the object platform by the sub-platform.

Abstract: Industrial internet of things (IoT) with a sensing network platform in a post-sub-platform type where an issuing cache is set and controlling method thereof are provided, which has adopted a form of a five-platform structure to construct an intelligent manufacturing industrial IoT. Each platform has a corresponding hardware device. As a service platform and a management platform adopt a centralized layout, while the sensing network platform adopts a post-sub-platform layout, the sensing network platform may receive large quantities of instructions issued by the management platform, and balance the coordination of various instructions at the same time, which makes the present disclosure very suitable for large-scale production lines with the requirement of high overall coordination and makes the present disclosure have strong applicability.

Abstract: Method for monitoring low-temperature pipeline based on smart gas, including: obtaining gas data and pipeline data of each segment of a gas pipeline and weather data of a position of each segment of the gas pipeline; determining at least one target pipeline; determining icing data of the at least one target pipeline by processing the gas data, the pipeline data, and the weather data of the at least one target pipeline based on an icing prediction model, wherein the icing prediction model is a machine learning model; and generating a thawing instruction based on the icing data, and controlling a natural gas heating device to perform a thawing operation on the at least one target pipeline based on the thawing instruction.

Abstract: The present disclosure provides an Industrial Internet of Things system conducive to system function expansion and system adjustment and control method thereof. The system comprises a user platform, a service platform, a management platform, a sensor network platform, and an object platform. The service platform and the sensor network platform adopt independent layout, and the management platform adopts centralized layout. The management platform is configured to store a control program that drives operation of production line equipment. The management platform is configured to call the control parameters in the database through communicating with the service platform and configure the control parameters in the control program to control the operation of production line equipment; and a data interaction mode between the user platform and the service platform is modifying and deleting the control parameters in the service platform through data transmission between the user platform and the service platform.

Abstract: A device is for surface strengthening of a metal plate based ultrasonic vibration is provided. The device includes an ultrasonic vibration tool holder and a cutting tool. The ultrasonic vibration tool holder is internally provided with an ultrasonic transducer and an ultrasonic booster; the ultrasonic transducer is configured to transmit vibration to the ultrasonic booster, the ultrasonic booster is configured to drive longitudinal torsion vibration of the cutting tool; an end of the ultrasonic booster facing towards the cutting tool is provided with an adjustment assembly configured for adjusting a longitudinal torsion angle and a rotation speed. Since the device includes the adjustment assembly, the longitudinal torsion angle and the rotation speed of the device can be adjusted according to different processing requirements, so as to perform ultrasonic vibration extrusion strengthening on surfaces of titanium alloy plates and improve surface integrity including microhardness and residual stress.

Abstract: A device is for surface strengthening of a metal plate based ultrasonic vibration. The device includes an ultrasonic vibration tool holder and a cutting tool. The ultrasonic vibration tool holder is internally provided with an ultrasonic transducer and an ultrasonic booster; the ultrasonic transducer is configured to transmit vibration to the ultrasonic booster, the ultrasonic booster is configured to drive longitudinal torsion vibration of the cutting tool; an end of the ultrasonic booster facing towards the cutting tool is provided with an adjustment assembly configured for adjusting a longitudinal torsion angle and a rotation speed. Since the device includes the adjustment assembly, the longitudinal torsion angle and the rotation speed of the device can be adjusted according to different processing requirements, so as to perform ultrasonic vibration extrusion strengthening on surfaces of titanium alloy plates and improve surface integrity including microhardness and residual stress.

Abstract: The disclosure relates to synthetic oligonucleotides that bind at least a portion of a dimerization initiation site (DIS) of a retrovirus genomic ribonucleic acid (RNA) molecule. In some aspects, the synthetic oligonucleotides include a 2?-deoxy-2?-fluoroarabinonucleotide (2?-FANA)-modified nucleotide sequence. In some embodiments, the 2?-FANA-modified nucleotide sequence inhibits dimerization of retroviral genomes (e.g., an HIV genome). Other embodiments include methods of inhibiting expression of a retrovirus using the synthetic oligonucleotide, and methods of treating or preventing a retroviral infection.

Abstract: The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and alcoholic and non-alcoholic steatohepatitis (NASH).

Abstract: The present invention relates to novel c-MYC mRNA translation modulators, composition and methods of preparation thereof, and uses thereof in the treatment of cancer.

Abstract: The disclosure relates to synthetic oligonucleotides that bind at least a portion of a dimerization initiation site (DIS) of a retrovirus genomic ribonucleic acid (RNA) molecule. In some aspects, the synthetic oligonucleotides include a 2-deoxy-2-fluoroarabinonucleotide (2-FANA)-modified nucleotide sequence. In some embodiments, the 2-FANA-modified nucleotide sequence inhibits dimerization of retroviral genomes (e.g., an HIV genome). Other embodiments include methods of inhibiting expression of a retrovirus using the synthetic oligonucleotide, and methods of treating or preventing a retroviral infection.

Abstract: The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Abstract: The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypo-function or basal ganglia dysfunction.

Abstract: The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Abstract: The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypo-function or basal ganglia dysfunction.