Abstract: A composition of substituted crotonamide pharmaceutical and a preparation method therefor. The pharmaceutical composition comprises 5-50 parts of (E)-N-(3-cyano-7-ethoxy-4-(3-ethynylphenylamino)quinolin-6-yl)-4-(dimethylamino)but-2-enamide maleate, 40-120 parts of a filler, 2-20 parts of a disintegrant, 0-6 parts of an adhesive, and 0.5-5 parts of a lubricant. The filler is selected from carbohydrates.

Abstract: An application of a substituted crotonamide, in particular being an application of (E)-N-(3-cyano-7-ethoxyl-4-(3-ethynylphenylamino)quinoline-6-yl)-4-(dimethylamino)but-2-enamide and a pharmaceutically acceptable salt and solvate thereof in the preparation of a drug for treating cancer mediated by a rare EGFR mutation.

Abstract: Provided is the use of an Abelmoschi corolla extract in the preparation of a drug for treating fibrosis, wherein the extract contains at least 15% of gossypetin-3-O-?-D-glucose-8-O-?-D-glucuronide, with same being prepared by means of the following method: taking medicinal materials of Abelmoschi corolla, heating same with ethanol and performing reflux extraction, performing filration, concentrating the filtrate, and carrying out macroporous resin column chromatography, where same is firstly washed with water, then eluting same with 3-7% of ethanol, eluting same with 9-15% of ethanol, and collecting 9-15% of an ethanol eluent in order to obtain the Abelmoschi corolla extract.