Abstract: This invention provides systems and methods for detecting the presence of cancer cell nucleic acids in a fluid sample. The fluid samples are applied to, e.g., a microfluidic cartridge input port to contact a surface that selectively adsorbs hypomethylated nucleic acids, which adsorption is detectable as, e.g., a change of impedance or vibration frequency at the surface.

Abstract: The present disclosure provides a display panel, a manufacturing method thereof, and a display device. The display panel includes: a first medium and a first spacer wall between the first substrate and the second substrate, wherein the first sub-panel has filter pixels arranged at intervals, the first spacer wall is black and arranged along spaces between filter pixels, and a dielectric coefficient of the first spacer wall is greater than that of the first medium; and a second sub-panel on a light emergent side of the first sub-panel and including a second medium and a second spacer wall between the third substrate and the fourth substrate, wherein the second sub-panel has display pixels arranged at intervals, the second spacer wall is black and arranged along spaces between display pixels, and a dielectric coefficient of the second spacer wall is greater than that of the second medium.

Abstract: Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.

Abstract: A color filter substrate, a manufacturing method thereof and a display device are provided. The color filter substrate includes: a base substrate; a black matrix on the base substrate, the black matrix including a plurality of openings and a bank surrounding each opening; a color filter layer in each opening; a first planarization layer covering the color filter layer, and the bank protruding relative to the first planarization layer in a direction away from the base substrate; a second planarization layer covering both the first planarization layer and the bank, the second planarization layer including a first surface distal to the base substrate; and a grating layer on the second planarization layer.

Abstract: Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.

Abstract: The present invention provides a charging system and a charging circuit thereof, including a circuit of a charging apparatus and a circuit of a wireless portable electronic device capable of recognizing an electric connection relationship with the charging apparatus.

Abstract: Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3? molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.

Abstract: The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with ?-opioid receptor. The polyamide compound of the invention has excellent ?-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain.

Abstract: The present disclosure provides a light receiving stacked-hole structure and a fabrication method thereof, and a fingerprint recognition device. The method includes forming a base light blocking layer having a first opening on a first surface of a substrate; forming at least one overlying light blocking layer having a second opening on a side of the base light blocking layer away from the substrate, wherein the overlying light blocking layer having the second opening is formed by using the base light blocking layer as a mask plate.

Abstract: A quantum dot optical function panel and its preparation method comprises a functional layer, a condensation layer and a diffusion layer which compose a multilayer structure. Said functional layer is located between condensation layer and diffusion layer. The functional layer comprises a main layer and quantum dots uniformly distributed in main layer. Said condensation layer comprises a condensation substrate layer and condensation bulges distributed over the upper surface of condensation substrate layer. Said diffusion layer comprises a diffusion substrate layer and diffusion bulges distributed over the lower surface of diffusion substrate layer. The condensation layer and diffusion layer of the quantum dot optical function panel of the present invention can resist oxygen and water vapor to a certain extent, protecting the quantum dots well.

Abstract: The present invention relates to novel 2-acylaminothiazole derivatives. The present invention also relates to the preparation method for these novel 2-acylaminothiazole derivatives and intermediates thereof, and a pharmaceutical composition containing these compounds. Moreover, the present invention also relates to these novel 2-acylaminothiazole derivatives and the pharmaceutical composition containing the same for use in treating and/or preventing thrombopoietin receptor mediated diseases.

Abstract: The method for collecting information includes: when a quantity of times of invoking a target method in a running lifecycle of a target program increases, obtaining, based on a method identifier of the target method, the quantity of times of invoking the target method; and recording method information of the target method based on the quantity of times of invoking the target method, a first threshold, and a second threshold, and setting a method status of the target method, the method status is one of a first state and a second state, the first state corresponds to the first threshold, the second state corresponds to the second threshold.

Abstract: Aspects of the disclosure provide a method for linking input files during a linking process. The method includes receiving an input section that is to be mapped to a memory segment by a linker circuit, determining whether an out-of-memory (OOM) event occurs when an available memory space of the memory segment is unable to accommodate the input section, estimating a memory expansion size that would be required for the memory segment to be able to accommodate the input section when an OOM event occurs, and creating by the linker circuit a map file that includes the estimated memory expansion size of the memory segment.

Abstract: A first embodiment of the implantable real-time oximeter of the present invention is attached around a blood vessel near the site of a likely stroke to monitor large and medium size cerebral arteries. Another embodiment of the implantable real-time oximeter can be passed within cerebral blood vessels to monitor the oxygenation status of the surrounding cerebral tissues. When used within cerebral blood vessels, the emitter and detector are coplanar and contained in a small area, for example, 50-120 ?m.

Abstract: There is provided an implantable pressure monitor having a fluid sack in contact with a body part of a patient where the fluid sack is retained to the body part by a pressure monitor housing that may have various attachment means. The fluid sack is filled with a liquid such as silicone oil. The pressure monitor housing has an opening that provides access to a fistula with a fluid valve that terminates through the fluid sack. A fiber optic pressure sensor is in contact with the liquid in the fluid sack by way of the fistula and fluid valve. In some embodiments of the present invention, an electronics module is incorporated with the implantable pressure monitor to provide telemetry, power, and the like.

Abstract: Aspects of the disclosure provide a method for identifying an induction variable in a loop during a compiling process. The method includes searching for a phi-function that includes a first operand and a second operand and defines a candidate basic induction variable (BIV), searching for an add/sub instruction that has a first register and a second register wherein the first register is the second operand of the phi-function, or the value in the first register is subsequently stored to the second operand of the phi-function through one or more move instructions, and determining the candidate BIV is a BIV when the second register of the add/sub instruction is the candidate BIV or stores a value that is passed from the candidate BIV through one or more move instructions.

Abstract: Aspects of the disclosure provide a method for null address handling. The method includes compiling code without adding a null check code before a memory access code, storing a first address of the memory access code in association with a second address of a handling code for null address, determining, in response to an exception that occurs at the first address during an execution of the compiled code, the second address based on the stored information, and executing the handling code at the second address.

Abstract: System and methods are provided for register allocation. An original code block and a target code block associated with a branch of an execution loop are determined. An original allocation of a plurality of physical registers to one or more original variables associated with the original code block is detected. A target allocation of the plurality of physical registers to one or more target variables associated with the target code block is determined. One or more temporary registers are selected from the plurality of physical registers based at least in part on the original allocation and the target allocation. The original allocation is changed to the target allocation using the selected temporary registers. Specifically, one or more instructions are generated to change the original allocation to the target allocation using the selected temporary registers. The instructions are executed using one or more processors.

Abstract: A deep brain magnetic stimulator is disclosed that is placed within a vessel of the body to provide targeted location specific application of a magnetic field within the brain. The deep brain magnetic stimulator has a stimulation coil affixed to an expandable device core where the device core has a lumen to allow the passage of blood. A source of electrical energy is provided as well as related control circuitry to govern the activation of the stimulation coil and also govern such parameters as magnetic field strength, duration, waveform, and the like.

Abstract: Aspects of the disclosure provide a method to support performance analysis. The method includes compiling bytecodes to generate native codes corresponding to the bytecodes in an electronic device, generating a file to include the bytecodes and the corresponding native codes in the file, collecting symbol information to map symbols in the bytecodes with offsets of corresponding native codes, and including the symbol information in the file to enable profiling.