Abstract: A biocontrol strain YW-1, a preparation method and application of a biocontrol agent thereof are provided. The strain is Myroides odoratimimus with the preservation number of CGMCC NO. 20620. The biocontrol agent of the biocontrol strain YW-1 is obtained by the following steps: oscillating culture the biocontrol strain YW-1 in a LB culture medium at 30 Celsius degrees and 180 rpm for 12-16 hours until a total concentration of living bacteria in a bacterial suspension is 1×109-1×1010 CFU/mL; centrifuging the bacterial suspension at 6000 rpm for 10 minutes to collect bacterial cells; and diluting the bacterial cells with sterilized water to obtain a concentration of 100 CFU/milliliter. By irrigating the root of every plant with 20 milliliters of the biocontrol agent when host plants are transplanted, it can effectively prevent soil-borne diseases such as fusarium wilt of melons, bacterial wilt of tomatoes and peppers, and Phytophthora capsici.

Abstract: Provided are a blood coagulation factor IX fusion protein with a prolonged circulation half-life, a conjugate thereof, a pharmaceutical composition containing same and the use of same in treating hemorrhagic diseases (such as hemophilia B).

Abstract: A biocontrol strain YW-1, a preparation method and application of a biocontrol agent thereof are provided. The strain is Myroides odoratimimus with the preservation number of CGMCC NO. 20620. The biocontrol agent of the biocontrol strain YW-1 is obtained by the following steps: oscillating culture the biocontrol strain YW-1 in a LB culture medium at 30 Celsius degrees and 180 rpm for 12-16 hours until a total concentration of living bacteria in a bacterial suspension is 1×109-1×1010 CFU/mL; centrifuging the bacterial suspension at 6000 rpm for 10 minutes to collect thalli; and diluting the thalli with sterilized water to obtain a concentration of 100 CFU/milliliter. By irrigating the root of every plant with 20 milliliters of the biocontrol agent when host plants are transplanted, it can effectively prevent soil-borne diseases such as fusarium wilt of melons, bacterial wilt of tomatoes and peppers, and phytophthora capsici.

Abstract: Provided by the present invention are a novel GLP-1 fusion protein and a conjugate thereof, a pharmaceutical composition containing same, and a use thereof in reducing blood sugar or body weight, especially for treating diabetes, in particular type II diabetes.