Abstract: A novel crystalline form of Tavapadon (hereinafter referred to as “Compound I”) and its preparation method, pharmaceutical compositions containing this crystalline form, and its use in the preparation of dopamine D1/D5 receptor agonist drugs and in the treatment of Parkinson's disease. The crystalline form of Compound I provided by the present disclosure has one or more improved properties compared to prior arts, which solve the problems of the prior art and is of great value to the optimization and development of the drugs.

Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.

Abstract: A lighting apparatus includes a driver housing, a first LED module, a first lens plate, a second LED module, a second lens plate, a first light wing, a second light wing, a first lens cover and a second lens cover. The first LED module emits a first light. The second LED module emits a second light. The first light wing has a first light opening and a first lens entrance. The first light passes through the first lens plate to escape from the first light opening. The first light wing and the second wing are disposed on two sides of the driver housing. The first lens cover is used for concealing the first lens entrance. The second lens cover is used for concealing the second lens entrance.

Abstract: Generative adversarial models have several benefits; however, due to mode collapse, these generators face a quality-diversity trade-off (i.e., the generator models sacrifice generation diversity for increased generation quality). Presented herein are embodiments that improve the performance of adversarial content generation by decelerating mode collapse. In one or more embodiments, a cooperative training paradigm is employed where a second model is cooperatively trained with the generator and helps efficiently shape the data distribution of the generator against mode collapse. Moreover, embodiments of a meta learning mechanism may be used, where the cooperative update to the generator serves as a high-level meta task and which helps ensures the generator parameters after the adversarial update stay resistant against mode collapse. In experiments, tested employments demonstrated efficient slowdown of mode collapse for the adversarial text generators.

Abstract: Method and apparatus for 5GS assisted adaptive AI or ML operation are disclosed. In one embodiment, an SMF comprises a processor; and a transceiver coupled to the processor, wherein the processor is configured to: receive, via the transceiver, app assistant information from a NG-RAN node, wherein the app assistant information includes at least one of predicted UL data rate of UE and predicted DL data rate of UE; and transmit, via the transceiver, the app assistant information to an AF.

Abstract: A light-emitting device includes at least one light-emitting unit. A light-emitting layer of the at least one light-emitting unit includes a first host material, a second host material, and a first light-emitting material. Photons emitted by the first light-emitting material include photons emitted due to energy obtained by fluorescence resonance energy transfer of the first and/or second host material and photons emitted due to excitons formed by recombination of electrons and holes. A ratio of a number of the photons emitted by the first light-emitting material to a number of photons emitted by the light-emitting layer is greater than 80%; a ratio of a number of the photons emitted by the first light-emitting material due to the energy obtained by fluorescence resonance energy transfer of the first and/or second host material to the number of the photons emitted by the first light-emitting material is greater than 60%.

Abstract: A gripper mechanism is provided, which relates to the technical field of grippers. The gripper mechanism includes a motor, a cylinder barrel, a piston and a guide assembly. The piston reciprocates in the cylinder barrel under the action of the motor and the guide assembly. The piston includes a piston body and a piston rod located in the piston body. Both ends of the cylinder barrel are respectively provided with cylinder heads for limiting the maximum distance and the minimum distance between the piston body and a part to be gripped. The piston rod includes a driving shaft, a cross slider coupling and a gripping head which are connected in turn. The power output by the motor is transmitted to the gripping head through the driving shaft and the cross slider coupling in turn.

Abstract: The present application provides an electrolytic solution for magnesium batteries, a method for preparing the same, and a magnesium battery, comprising a non-aqueous solvent and an electrolyte salt, wherein the non-aqueous solvent is selected from one or more of imidazole ionic liquids, pyrrole ionic liquids, piperidine ionic liquids, ether compounds, ester compounds, pyridine compounds, nitrile compounds, sulfone compounds, or ketone compounds; the electrolyte salt has a chemical formula [MgmLinXo(HMDS)2m+m?oRp]·Mq.

Abstract: The present application discloses a sound absorbing device to be placed in an airflow that is in a first direction. The sound absorbing device includes a housing; a plurality of sound absorbing units disposed in the housing to be passed by the airflow, the plurality of sound absorbing units being arranged in a direction perpendicular to the first direction, any two adjacent sound absorbing units being separated by a gap; and a plurality of supports fixed in the housing. The plurality of sound absorbing units are fixed to the housing through the plurality of supports.

Abstract: A hydrokinetic turbine system for harvesting energy from riverine and tidal sources, including a first floating dock, a marine hydrokinetic turbine mounted on the first floating dock, and a second floating dock. The system further includes a winch assembly mounted on the second floating dock and operationally connected to the first floating dock and a linkage assembly operationally connected to the first floating dock and to the second floating dock. The linkage assembly may be actuated to pull the first floating dock into contact with the second floating dock. The linkage assembly may be actuated to distance the first floating dock from the second floating dock, and the winch assembly may be energized to orient the first floating dock into a position wherein the marine hydrokinetic turbine is above the first floating dock and wherein the winch assembly may be energized to orient the first floating dock into a position wherein the marine hydrokinetic turbine is below the first floating dock.

Abstract: Provided is a binding molecule specific for LIF and use thereof. Specifically, provided is an isolated antibody or an antigen-binding fragment thereof that binds to LIF and inhibits the activity of LIF. Also provided are uses of the isolated antibody or the antigen-binding fragment thereof in treatment of diseases.

Abstract: The present application provides a glabridin composition with high skin permeability and a preparation method and use thereof, belonging to the field of cosmetics. The glabridin composition is prepared from an S1 phase, an S2 phase and an S3 phase, in which the S1 phase consists of an oil and glabridin, the S2 phase is prepared from 3-o-ethyl ascorbic acid, an anionic surfactant, a nonionic surfactant, a polyol and water, and the S3 phase is water. The glabridin composition is prepared by conventional emulsifying equipment, and has low preparation cost, and simple operation process. The composition has good skin permeability, and has good state stability, good content stability, good pH stability and high mildness under high temperature and low temperature conditions, thus having unexpected technical effects.

Abstract: A method of managing a virtual machine (VM) image for deployment of the VM across a plurality of software-defined data centers (SDDCs) includes the steps of: separately uploading parts of the VM image to a cloud storage, forming a complete image of the VM from the separately uploaded parts of the VM image, and downloading from the cloud storage the complete VM image to each of the SDDCs in which the VM is to be deployed.

Abstract: A display panel includes a backplane and a plurality of light-emitting devices located on the backplane. A light-emitting device includes a first electrode and a second electrode arranged oppositely, the first electrode being closer to the backplane than the second electrode; a light extraction layer located on a light exit side of the plurality of light-emitting devices, the light extraction layer being configured to allow circularly polarized light of a first rotation direction to pass through and reflect circularly polarized light of a second rotation, the first rotation direction being different from the second rotation direction; and an anti-reflection layer located on the light extraction layer, the anti-reflection layer being configured to allow the circularly polarized light of the first rotation direction to pass through.

Abstract: Disclosed are a high-selectivity KCNQ4 potassium channel agonist of formula I, a preparation method therefor and the use thereof. The compound further improves the KCNQ4 agonistic activity, and is still free of KCNQ2 agonistic activity, thus having excellent KCNQ4/KCNQ2 selectivity. The high-selectivity KCNQ4 agonist overcomes the defect of poor selectivity of existing potassium channel agonists, the activity is relatively increased, and the toxicity is remarkably reduced. The agonist also has a simpler structure and lower product cost, thereby having a better development prospect.

Abstract: A wide-field imaging and hyperspectral collaborative early warning system and method are provided. The system includes: a primary imaging system, a digital micromirror array, a first collimation system, a second collimation system, a first reflector, a second reflector, a wide-field imaging optical filter, a narrow-band optical filter, a wide-field imager and a hyperspectral interferometer. The system and method have the advantages that the wide-field imaging general survey and fine spectrum detection can be realized synchronously, the functions are multiple, and the false alarm rate is low; the target spatial resolution of the fine spectrum identification is adjustable, the micro-control unit flipping solution is simple to operate, and quick adjustment is realized; the adaptability is strong, the flipping time of the corresponding micro-control unit is adaptively adjusted for the measured target with too low or too strong radiation intensity, and the dynamic range of the system is effectively improved.

Abstract: The present invention discloses a dual-drug co-delivery system, a preparation method therefor and use thereof, the dual-drug co-delivery system being prepared from raw materials comprising a block copolymer, Homoharringtonine and Doxorubicin hydrochloride. The dual-drug co-delivery system provided by the present invention has a stronger killing effect on various hematologic tumors and solid tumor cells, can provide a feasible drug delivery system for inhibiting tumor growth and leukemia treatment, and has broad prospects.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: Methods and compositions for treating a siliceous geologic formation are described herein. An aqueous treatment composition for treating such formations includes an acid having molecular weight less than about 200, or an ammonium or sodium salt thereof, an HF source, and from about 0.1 wt % to about 2.0 wt % of a fluoride scale inhibitor, the aqueous treatment composition having a pH from about 1.0 to about 3.0.