Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: Disclosed is a carbon-dioxide-responsive self-thickening intelligent fluid based on supramolecular self-assembly, which comprises a Gemini surfactant, a single-chain amide molecule having a tertiary amine head group and water, wherein the Gemini surfactant and the single-chain amide molecule are self-assembled to form a vesicle structure dispersed in water, with a hydrophilic head group being located outside and a hydrophobic tail group located inside. The method for preparing the carbon-dioxide-responsive self-thickening intelligent fluid of the present invention is simple, the injection viscosity is low, and the fluid is converted into a gel when encountering carbon dioxide, so that the viscosity is greatly increased.

Abstract: The present application provides a passive aggregation-layer network device, a network system, and a working method. The passive aggregation-layer network device includes a first multiplexer/demultiplexer, a second multiplexer/demultiplexer, and an optical fiber. The first multiplexer/demultiplexer receives optical signals of optical modules of access-layer network devices connected to the first multiplexer/demultiplexer, couples the received optical signals to obtain a first coupled optical signal, and sends the first coupled optical signal to the second multiplexer/demultiplexer by using the optical fiber. The second multiplexer/demultiplexer decouples the first coupled optical signal, and transmits obtained optical signals to corresponding optical modules of core-layer network devices.

Abstract: Provided are a photoactive compound having a chemical structure of formula (I), a photoactive protein-immobilizing gel and use. The photoactive protein-immobilizing gel, in which the photoactive compound is contained or immobilized, can crosslink with a protein under the action of UV light, thereby achieving separation and/or immobilization of the protein.

Abstract: A microfluidic chip comprises: a first unit which has a channel for a cell sample to pass through and is configured to separate circulating tumor cells in the cell sample; a second unit, a front end of which communicates with a tail end of the first unit, and the second unit is configured to capture single cells from the separated circulating tumor cells and subject the captured single cells to closed lysis; and a gel layer which is provided at the second unit. The microfluidic chip is configured to implement the binding of a protein molecule of the single cell with an antibody in the gel layer after the single cell is lysed. A cell separation and western blotting method using the microfluidic chip comprises: lysing circulating tumor cells, capturing, and implementing the binding of a lysate with an antibody.