Patents by Inventor Haizhen LIU

Haizhen LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONDITIONALLY ACTIVE PROTEINS FOR NEURODEGENERATIVE DISEASES
    Publication number: 20240400659
    Abstract: A polypeptide or conditionally active protein suitable for prevention or treatment of a neurodegenerative disease that binds to ApoE. The conditionally active protein binds to ApoE with an increased binding activity at an aberrant condition such as an acidic pH in a dementia brain in comparison with the binding activity to ApoE at a normal physiological condition such as the pH of blood. A method for generating the conditionally active protein is also provided.
    Type: Application
    Filed: October 17, 2022
    Publication date: December 5, 2024
    Applicant: BioAtla, Inc.
    Inventors: Jay M. Short, Christina Wheeler, Jing Wang, Matthew Lucas, Haizhen Liu, Hwai Wen Chang, Gerhard Frey
  • CONDITIONALLY ACTIVE ANTI-NECTIN-4 ANTIBODIES
    Publication number: 20230235054
    Abstract: Isolated polypeptides having a heavy chain variable region and/or light chain variable region that specifically binds to Nectin-4 protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to Nectin-4 protein. Pharmaceutical compositions and kits comprising the polypeptide and antibodies and antibody fragments containing the polypeptide are also provided.
    Type: Application
    Filed: June 15, 2021
    Publication date: July 27, 2023
    Applicant: BIOATLA, INC.
    Inventors: Jay M. SHORT, Gerhard FREY, Hwai Wen CHANG, Jing WANG, Chao XING, Haizhen LIU, Ana Paula CUGNETTI