Patents by Inventor Haizhou SUN

Haizhou SUN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC URSOLIC ACID DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20240140986
    Abstract: Disclosed herein are compounds of Formula (I-A), wherein the vari-ables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 2, 2024
    Inventors: Xin JIANG, Ha DO, Haizhou SUN, Melean VISNICK, Robert M. KRAL, JR.
  • SYNTHETIC TRITERPENOIDS WITH NITROGEN-BASED SUBSTITUENTS AT C-17 AND METHODS OF USE THEREOF
    Publication number: 20230111914
    Abstract: In some aspects, the present disclosure provides compounds of the formula: (I) and (II), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.
    Type: Application
    Filed: December 18, 2020
    Publication date: April 13, 2023
    Inventors: Christopher F. BENDER, Ha DO, Xin JIANG, Haizhou SUN, Melean VISNICK, Ingo JANSER, Lloyd J. SIMONS, Heinrich J. SCHOSTAREZ
  • C17 POLAR-SUBSTITUTED HETEROAROMATIC SYNTHETIC TRITERPENOIDS AND METHODS OF USE THEREOF
    Publication number: 20210040142
    Abstract: Disclosed herein are compounds of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders, including those associated with inflammation and cancer.
    Type: Application
    Filed: July 20, 2020
    Publication date: February 11, 2021
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Xin JIANG, Christopher F. BENDER, Ha DO, Haizhou SUN, Melean VISNICK
  • A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
    Patent number: 9556222
    Abstract: Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: January 31, 2017
    Assignee: REATA PHARMACEUTICALS, INC.
    Inventors: Eric Anderson, Christopher F. Bender, Xin Jiang, Xiaofeng Liu, Haizhou Sun, Melean Visnick
  • A-RING EPOXIDIZED TRITERPENOID-BASED ANTI-INFLAMMATION MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20150148384
    Abstract: Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 28, 2015
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Eric Anderson, Christopher F. Bender, Xin Jiang, Xiaofeng Liu, Haizhou Sun, Melean Visnick
  • Smac mimetic dimers and trimers useful as anti-cancer agents
    Patent number: 8642554
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: February 4, 2014
    Assignee: Joyant Pharmaceuticals, Inc.
    Inventors: Gunnar Hanson, Haizhou Sun
  • Dimeric Smac Mimetics
    Publication number: 20130344026
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Application
    Filed: August 22, 2013
    Publication date: December 26, 2013
    Inventors: Haizhou Sun, Xiaoming Xu, Ming Zhou, Susan Harran, Gunnar James Hanson, Lai Wang
  • Dimeric Smac mimetics
    Patent number: 8551955
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: October 8, 2013
    Assignee: Joyant Pharmaceuticals, Inc.
    Inventors: Haizhou Sun, Xiaoming Xu, Ming Zhou, Susan Harran, Gunnar James Hanson, Lai Wang
  • Dimeric Smac Mimetics
    Publication number: 20110195043
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Application
    Filed: October 28, 2010
    Publication date: August 11, 2011
    Inventors: Haizhou Sun, Xiaoming Xu, Ming Zhou, Susan Harran, Gunnar James Hanson, Lai Wang
  • SMAC MIMETIC DIMERS AND TRIMERS USEFUL AS ANTI-CANCER AGENTS
    Publication number: 20090104151
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Application
    Filed: April 11, 2008
    Publication date: April 23, 2009
    Applicant: Joyant Pharmaceuticals, Inc
    Inventors: Gunnar HANSON, Haizhou SUN