Patents by Inventor Hajime Aga

Hajime Aga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8188268
    Abstract: An object of the present invention is to provide a crystalline saccharide having novel physical properties, a preparation and uses thereof. The present invention solves the above objects by providing a porous crystalline saccharide having a number of pores, a process for producing the same, comprising the step of keeping hydrous crystalline saccharide at an ambient temperature or higher in an organic solvent for the dehydration, and the use thereof.
    Type: Grant
    Filed: December 25, 2006
    Date of Patent: May 29, 2012
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Tetsuya Ohashi, Hajime Aga, Tetsuya Nakada, Toshio Miyake
  • Patent number: 8168779
    Abstract: Objects of the present invention are to provide a novel anhydrous crystalline ?-maltose, its preparation and uses. The present invention attains the above objects by providing an anhydrous crystalline ?-maltose with a melting point of 154 to 159° C.; a process for producing the same, comprising a step of keeping hydrous crystalline ?-maltose in an organic solvent at an ambient temperature or higher for the dehydration; and uses of the same.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: May 1, 2012
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Tetsuya Ohashi, Hajime Aga, Tetsuya Nakada, Toshio Miyake
  • Publication number: 20100222569
    Abstract: An object of the present invention is to provide a crystalline saccharide having novel physical properties, a preparation and uses thereof. The present invention solves the above objects by providing a porous crystalline saccharide having a number of pores, a process for producing the same, comprising the step of keeping hydrous crystalline saccharide at an ambient temperature or higher in an organic solvent for the dehydration, and the use thereof.
    Type: Application
    Filed: December 25, 2006
    Publication date: September 2, 2010
    Inventors: Tetsuya Ohashi, Hajime Aga, Tetsuya Nakada, Toshio Miyake
  • Publication number: 20090292116
    Abstract: Objects of the present invention are to provide a novel anhydrous crystalline ?-maltose, its preparation and uses. The present invention attains the above objects by providing an anhydrous crystalline ?-maltose with a melting point of 154 to 159° C.; a process for producing the same, comprising a step of keeping hydrous crystalline ?-maltose in an organic solvent at an ambient temperature or higher for the dehydration; and uses of the same.
    Type: Application
    Filed: July 5, 2007
    Publication date: November 26, 2009
    Inventors: Tetsuya Ohashi, Hajime Aga, Tetsuya Nakada, Toshio Miyake
  • Publication number: 20080027027
    Abstract: An object of the present invention is to provide a lactosucrose high content saccharide which comprises 70% or more of lactosucrose, on a saccharide composition basis, with a lower content of 1-kestose and fructosyl lactosucrose as by-products. Another object of the present invention is to provide processes for producing a lactosucrose high content saccharide and high purity lactosucrose containing 90% or more of lactosucrose, on a saccharide composition basis, which are feasible for industrial production. Further object of the present invention is to provide a solid lactosucrose with low hygroscopicity and a solid composition comprising the same.
    Type: Application
    Filed: April 20, 2005
    Publication date: January 31, 2008
    Inventors: Hiroyuki Okabe, Hajime Aga, Michio Kubota, Toshio Miyake
  • Patent number: 7223570
    Abstract: The object of the present invention is to provide a novel glycosyl derivative of cyclotetrasaccharide represented by cyclo{?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?}, and it is solved by providing a branched cyclotetrasaccharide, wherein one or more hydrogen atoms in the hydroxyl groups of cyclotetrasaccharide are replaced with an optionally substituted glycosyl group, with the proviso that, when only one hydrogen atom in the C-6 hydroxyl group among the above hydrogen atoms is substituted with an optionally-substituted glycosyl group, the substituted glycosyl group is one selected from those excluding D-glucosyl group.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: May 29, 2007
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hajime Aga, Takanobu Higashiyama, Hikaru Watanabe, Tomohiko Sonoda, Michio Kubota
  • Patent number: 7192746
    Abstract: The object of the present invention is to provide an ?-isomaltosyl-transferring enzyme which forms a cyclotetrasaccharide having the structure of cyclo{?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?} from a saccharide having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end; microorganisms which produce the enzyme; process for producing the enzyme; cyclotetrasaccharide or saccharide compositions comprising the same; and uses thereof.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: March 20, 2007
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Michio Kubota, Tomoyuki Nishimoto, Hajime Aga, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 7186701
    Abstract: The present invention has the object to dehydrate hydrous matters without denaturing or deteriorating them by using a dehydrating agent comprising an anhydrous cyclotetrasaccharide, and provides a dehydrating agent comprising the cyclotetrasaccharide; a method for dehydrating hydrous matters through a step of incorporating, contacting or coexisting the cyclotetrasaccharide into, with, or in the hydrous matters; and dehydrated products obtainable thereby.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: March 6, 2007
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Michio Kubota, Tomoyuki Nishimoto, Hajime Aga, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 7186824
    Abstract: A reduction inhibitory agent for active-oxygen eliminating activity comprises trehalose as an effective ingredient. A method for inhibiting the reduction of active-oxygen eliminating activity comprises incorporating either trehalose or the reduction inhibitory agent into plant edible products and/or plant antioxidants. A composition is provided that reduces the active-oxygen eliminating activity of plant edible products and/or plant antioxidants.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: March 6, 2007
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hajime Aga, Takashi Shibuya, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20060041118
    Abstract: The present invention has objects to provide a novel high pullulan content liquid and a method for transporting the same, and solves the objects by providing a high pullulan content liquid which has a viscosity of 2.5 mm2/s or more in terms of a pullulan concentration of 10% (w/w) when determined at 30° C. on the Ubelode viscometer method, a common bacterial count of less than 300 cells/g product, a negativity with respect to coliform group, a pH of 4.5 to 7.5, and a pullulan concentration of 20% (w/w) or more; and by providing a method for transporting the same under a prescribed temperature condition.
    Type: Application
    Filed: November 20, 2003
    Publication date: February 23, 2006
    Inventors: Mitsuyuki Kanbe, Ikuo Sawatani, Hajime Aga
  • Publication number: 20060008791
    Abstract: The present invention has the object to dehydrate hydrous matters without denaturing or deteriorating them by using a dehydrating agent comprising an anhydrous cyclotetrasaccharide, and provides a dehydrating agent comprising the cyclotetrasaccharide; a method for dehydrating hydrous matters through a step of incorporating, contacting or coexisting the cyclotetrasaccharide into, with, or in the hydrous matters; and dehydrated products obtainable thereby.
    Type: Application
    Filed: January 17, 2002
    Publication date: January 12, 2006
    Inventors: Michio Kubota, Tomoyuki Nishimoto, Hajime Aga, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20050009017
    Abstract: The object of the present invention is to provide an ?-isomaltosyl-transferring enzyme which forms a cyclotetrasaccharide having the structure of cyclo{?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?} from a saccharide having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end; microorganisms which produce the enzyme; process for producing the enzyme; cyclotetra-saccharide or saccharide compositions comprising the same; and uses thereof.
    Type: Application
    Filed: May 22, 2001
    Publication date: January 13, 2005
    Inventors: Michio Kubota, Tomoyuki Nishimoto, Hajime Aga, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20040236097
    Abstract: The object of the present invention is to provide a novel glycosyl derivative of cyclotetrasaccharide represented by cyclo{→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→}, and it is solved by providing a branched cyclotetrasaccharide, wherein one or more hydrogen atoms in the hydroxyl groups of cyclotetrasaccharide are replaced with an optionally substituted glycosyl group, with the proviso that, when only one hydrogen atom in the C-6 hydroxyl group among the above hydrogen atoms is substituted with an optionally-substituted glycosyl group, the substituted glycosyl group is one selected from those excluding D-glucosyl group.
    Type: Application
    Filed: September 9, 2003
    Publication date: November 25, 2004
    Inventors: Hajime Aga, Takanobu Higashiyama, Hiraku Watanabe, Tomohiko Sonoda, Michio Kubota
  • Publication number: 20040058592
    Abstract: A reduction inhibitory agent for active-oxygen eliminating activity which comprises trehalose as an effective ingredient, a method for inhibiting the reduction of active-oxygen eliminating activity which comprises incorporating either trehalose or the reduction inhibitory agent into plant edible products and/or plant antioxidants, and a composition where the reduction of active-oxygen eliminating activity of the plant edible products and/or plant antioxidants is satisfactorily inhibited by the method.
    Type: Application
    Filed: September 26, 2003
    Publication date: March 25, 2004
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Hajime Aga, Takashi Shibuya, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 6524625
    Abstract: A physiologically active extract comprising an ethyl acetate-soluble ingredient of an indigo plant, which is obtainable by soaking a raw indigo plant in an organic solvent used for extraction. The ethyl acetate-soluble ingredient includes tryptanthrin, 3,5,4′-trihydroxy-6,7-methylenedioxy-flavone, kaempferol, 3,5,7,4′-tetrahydroxy-6-methoxy-flavone, gallic acid, caffeic acid, indirubin, pheophorbide a, and methylpheophorbide a.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: February 25, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyuto
    Inventors: Hajime Aga, Shigeyuki Arai, Shigeharu Fukuda, Toshio Kunikata, Masashi Kurimoto
  • Publication number: 20020068094
    Abstract: A physiologically active extract comprising an ethyl acetate-soluble ingredient of an indigo plant, which is obtainable by soaking a raw indigo plant in an organic solvent used for extraction. The ethyl acetate-soluble ingredient includes tryptanthrin, 3,5,4′-trihydroxy-6,7-methylenedioxy-flavone, kaempferol, 3,5,7,4′-tetrahydroxy-6-methoxy-flavone, gallic acid, caffeic acid, indirubin, pheophorbide a, and methylpheophorbide a.
    Type: Application
    Filed: June 25, 1999
    Publication date: June 6, 2002
    Inventors: HAJIME AGA, SHIGEYUKI ARAI, TOSHIO KUNIKATA, MASASHI KURIMOTO
  • Publication number: 20020055620
    Abstract: A reduction inhibitory agent for active oxygen eliminating activity comprises trehalose as an active ingredient. This agent can be incorporated into plant edible products and/or plant antioxidants.
    Type: Application
    Filed: October 30, 2001
    Publication date: May 9, 2002
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Hajime Aga, Takashi Shibuya, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 6153228
    Abstract: A propolis extract having a reduced peculiar odor is prepared by deceasing the amount of odorizing ingredients. This propolis extract can be used to prepare biologically active compositions.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: November 28, 2000
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takashi Shibuya, Kazuyuki Oku, Hajime Aga, Shigeharu Fukuda
  • Patent number: 6153227
    Abstract: Disclosed are a propolis extract where the peculiar odor of propolis is reduced by decreasing the odorizing ingredients, a process to produce the propolis extract which comprises soaking propolis in a hydrophilic organic solvent to effect extraction and treating the liquid layer in the resultant extract with an anion-exchange resin, and a biologically active composition comprising the propolis extract.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: November 28, 2000
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takashi Shibuya, Kazuyuki Oku, Hajime Aga, Shigeharu Fukuda
  • Patent number: 5922324
    Abstract: A propolis extract which is prepared by adjusting the pH of propolis to 5.5-7.0 to improve the water-solubility of the effective ingredients of propolis, a composition containing the propolis extract, and a method for improving the water-solubility of propolis extracts.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: July 13, 1999
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hajime Aga, Takashi Shibuya, Shoichi Hamada, Satoshi Iritani, Toshio Miyake