Patents by Inventor Hajime Yoshikoshi

Hajime Yoshikoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of producing cis-whiskey lactone
    Patent number: 5468881
    Abstract: After the lactone portion of trans-whiskey lactone is hydrolyzed with potassium hydroxide, this portion is reacted with isopropyl bromide and mixed with an alkyl group, thereby obtaining isopropyl (3S,4S)-4-hydroxy-3-methyloctanoate. Then, the isopropyl (3S,4S)-4-hydroxy-3-methyloctanoate is reacted with diethyl azodicarboxylate in the presence of triphenylphosphine and azodicarboxylate, thereby obtaining isopropyl (3S,4S)-4-(3',5'-dinitrobenzoyloxy)-3-methyloctanoate. The isopropyl (3S,4S)-4-(3',5'-dinitrobenzoyloxy)-3-methyloctanoate is hydrolyzed in 2% potassium hydroxide, and as a result, cis-whiskey lactone (A) represented by the following general formula is obtained. According to this method, cis-whiskey lactone, one of the perfume components of whiskey and wine, can be produced selectively and easily.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: November 21, 1995
    Assignees: Japan Tobacco Inc., Yuji Gosei Kogyo Co., Ltd.
    Inventors: Takashi Ebata, Katsuya Matsumoto, Koshi Koseki, Hiroshi Kawakami, Hajime Matsushita, Hajime Yoshikoshi, Masakazu Okaniwa