Patents by Inventor Hajimu Hirofuji

Hajimu Hirofuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized and lyophilized formulation of anthracycline compounds
    Patent number: 8785406
    Abstract: The present invention provides a lyophilized amrubicin formulation and a process thereof. In the process, the concentration of the aqueous solution before lyophilization is controlled to about 7.5 mg(potency)/mL or more. Thus, the formulation decreases the production of desaccharified compound and is stable to storage for a long period. The formulation is useful as a cancer chemotherapeutic agent.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: July 22, 2014
    Assignee: Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Hajimu Hirofuji, Hotaka Hashimoto, Kazunari Tanaka
  • Freeze-dried preparation of stabilized anthracycline compound
    Patent number: 8445653
    Abstract: The present invention provides a lyophilized preparation of amrubicin, which contains L-cysteine or a salt thereof and has a water content of 0 to about 4% by weight within the preparation, and is stable even in a long-term storage, and further provides a method for production of said preparation. Said preparation is useful as a chemotherapeutic agent for cancers.
    Type: Grant
    Filed: November 27, 2003
    Date of Patent: May 21, 2013
    Assignee: Dainippon Sumitomo Pharma
    Inventors: Hajimu Hirofuji, Hotaka Hashimoto
  • STABILIZED AND LYOPHILIZED FORMULATION OF ANTHRACYCLINE COMPOUNDS
    Publication number: 20120077768
    Abstract: The present invention provides a lyophilized amrubicin formulation and a process thereof. In the process, the concentration of the aqueous solution before lyophilization is controlled to about 7.5 mg(potency)/mL or more. Thus, the formulation decreases the production of desaccharified compound and is stable to storage for a long period. The formulation is useful as a cancer chemotherapeutic agent.
    Type: Application
    Filed: May 27, 2009
    Publication date: March 29, 2012
    Applicant: Daninippon Sumitomo Pharma Co., Ltd
    Inventors: Hajimu Hirofuji, Hotaka Hashimoto, Kazunaria Tanaka
  • LYOPHILIZED PREPARATION OF STABILIZED ANTHRACYCLINE COMPOUNDS
    Publication number: 20110021452
    Abstract: The present invention provides a lyophilized preparation of amrubicin, which contains L-cysteine or a salt thereof and has a water content of 0 to about 4% by weight within the preparation, and is stable even in a long-term storage, and further provides a method for production of said preparation. Said preparation is useful as a chemotherapeutic agent for cancers.
    Type: Application
    Filed: September 17, 2010
    Publication date: January 27, 2011
    Applicant: Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Hajimu Hirofuji, Hotaka Hashimoto
  • Freeze-dried preparation of stabilized anthracycline compound
    Publication number: 20060003949
    Abstract: The present invention provides a lyophilized preparation of amrubicin, which contains L-cysteine or a salt thereof and has a water content of 0 to about 4% by weight within the preparation, and is stable even in a long-term storage, and further provides a method for production of said preparation. Said preparation is useful as a chemotherapeutic agent for cancers.
    Type: Application
    Filed: November 27, 2003
    Publication date: January 5, 2006
    Applicant: Sumitomo Pharmaceuticals Co. Ltd.
    Inventors: Hajimu Hirofuji, Hotaka Hashimoto