Patents by Inventor Hak Suk CHUNG

Hak Suk CHUNG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of screening inhibitor of caspase activity by lipopolysaccharide
    Patent number: 11926860
    Abstract: Provided are a method of screening an inhibitor of caspase activity by lipopolysaccharide and a method of screening a therapeutic agent for inflammatory diseases or sepsis using the same. Accordingly, it is possible to develop a caspase-4-specific inhibitor.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: March 12, 2024
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hak Suk Chung, Jinsu An, Eun Gyeong Yang, So Yeon Kim
  • METHOD FOR PRODUCING MONOPHOSPHORYL LIPID A
    Publication number: 20220259633
    Abstract: Provided is a method of producing monophosphoryl lipid A (MPLA). According to the method, MPLA may be produced with high purity and high purity by using a bacterium producing MPLA.
    Type: Application
    Filed: August 26, 2020
    Publication date: August 18, 2022
    Applicants: EUBIOLOGICS CO., LTD., KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Chan Kyu LEE, Da Hui HA, Choon Geun LEE, Ye Ram LEE, Hak Suk CHUNG
  • METHOD OF SCREENING INHIBITOR OF CASPASE ACTIVITY BY LIPOPOLYSACCHARIDE
    Publication number: 20220220529
    Abstract: Provided are a method of screening an inhibitor of caspase activity by lipopolysaccharide and a method of screening a therapeutic agent for inflammatory diseases or sepsis using the same. Accordingly, it is possible to develop a caspase-4-specific inhibitor.
    Type: Application
    Filed: September 27, 2021
    Publication date: July 14, 2022
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hak Suk CHUNG, Jinsu AN, Eun Gyeong YANG, So Yeon KIM
  • Novel tracrRNA system for Cas9
    Publication number: 20220090065
    Abstract: The present invention relates to a novel trans-activating CRISPR RNA (tracrRNA) including a fragment of a tracrRNA, and a gRNA, a CRISPR-Cas9 system, and a kit including the tracrRNA.
    Type: Application
    Filed: September 2, 2021
    Publication date: March 24, 2022
    Inventors: Dae-Ro AHN, Jihyun PARK, Hak Suk CHUNG, Cherlhyun JEONG
  • Method of producing monomeric card in bacteria
    Patent number: 10640756
    Abstract: Provided is a method of producing monomeric caspase activation and recruitment domains (CARDs) in bacteria. According to this method, CARD domains may be easily produced in a monomeric form. Monomeric CARDs may be applied to studies on the mechanism of action of caspase, the development of new drugs, detection and elimination of endotoxins, development of cosmetics, etc.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: May 5, 2020
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hak Suk Chung, Jinsu An, Eun Gyeong Yang, So Yeon Kim
  • Bacterium constitutively producing monophosphoryl lipid A and method of producing monophosphoryl lipid A by using bacterium
    Patent number: 10557156
    Abstract: A bacterium that constitutively produces monophosphoryl lipid A (MLA) and a method of producing MLA by using the bacterium may simply produce MLA and a derivative thereof without acid hydrolysis, reduce a probability of natural mutation, and increase yields of MLA and a derivative thereof by constitutive expression of the MLA and derivative thereof.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: February 11, 2020
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hak Suk Chung, Yu Hyun Ji, Jin Su An, Ick Chan Kwon, Eun Gyeong Yang
  • METHOD OF PRODUCING MONOMERIC CARD IN BACTERIA
    Publication number: 20190338265
    Abstract: Provided is a method of producing monomeric caspase activation and recruitment domains (CARDs) in bacteria. According to this method, CARD domains may be easily produced in a monomeric form. Monomeric CARDs may be applied to studies on the mechanism of action of caspase, the development of new drugs, detection and elimination of endotoxins, development of cosmetics, etc.
    Type: Application
    Filed: January 10, 2019
    Publication date: November 7, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hak Suk CHUNG, Jinsu AN, Eun Gyeong YANG, So Yeon KIM
  • Bacterium producing monophosphoryl lipid A and method of producing monophosphoryl lipid A by using bacterium
    Patent number: 10308945
    Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 4, 2019
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hak Suk Chung, Eun Gyeong Yang, Dohyeon Hwang
  • BACTERIUM CONSTITUTIVELY PRODUCING MONOPHOSPHORYL LIPID A AND METHOD OF PRODUCING MONOPHOSPHORYL LIPID A BY USING BACTERIUM
    Publication number: 20190010528
    Abstract: A bacterium that constitutively produces monophosphoryl lipid A (MLA) and a method of producing MLA by using the bacterium may simply produce MLA and a derivative thereof without acid hydrolysis, reduce a probability of natural mutation, and increase yields of MLA and a derivative thereof by constitutive expression of the MLA and derivative thereof.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 10, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hak Suk Chung, Yu Hyun Ji, Jin Su An, Ick Chan Kwon, Eun Gyeong Yang
  • BACTERIUM PRODUCING MONOPHOSPHORYL LIPID A AND METHOD OF PRODUCING MONOPHOSPHORYL LIPID A BY USING BACTERIUM
    Publication number: 20170191071
    Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.
    Type: Application
    Filed: December 14, 2016
    Publication date: July 6, 2017
    Inventors: Hak Suk CHUNG, Eun Gyeong YANG, Dohyeon HWANG