Patents by Inventor Hakan Roos
Hakan Roos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10663461Abstract: A method of screening a plurality of fluid samples for the presence of species capable of specifically binding to a binding partner immobilized on a sensing surface of a sensor is disclosed. The method comprises contacting each sample with the sensing surface and a reference surface, and subjecting the sensing surface responses obtained for all samples to a computational process which comprises fitting al responses to a model equation for the relationship between a response at the sensing surface and the corresponding response at the reference surface. In an iterative process residuals above a pre-determined threshold value are removed, the model equation is adjusted, and all remaining samples are refitted to the adjusted model equation until the model equation at least substantially converges. Residuals above the predetermined threshold value are considered as species specifically binding to the binding partner.Type: GrantFiled: November 29, 2011Date of Patent: May 26, 2020Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Markku Hamalainen, Hakan Roos
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Publication number: 20190184075Abstract: Disclosed is a contact layer for a negative pressure wound treatment system, in which the contact layer includes as inflatable channel with an opening for inflation or deflation of a fluid. The contact layer is flexible to be kept close to the intestines and to be possible to wrinkle or fold it in order to fit into the wound. To keep it in the desired position once this is achieved since the contact layer is thin and lacks rigidity and stability and may thus easily be dislocated, the contact layer allows the inflatable channel to be in an uninflated, or slightly inflated, state from the start to be able to easily wrinkle and fold the contact layer first and thereafter, during or after placing the contact layer in position, inflating the channel to increase the rigidity and stability to help to keep the contact layer in its desired position.Type: ApplicationFiled: August 22, 2017Publication date: June 20, 2019Inventor: Håkan ROOS
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Publication number: 20140147937Abstract: A method of determining active concentration of an analyte in a sample comprises the steps of: (a) contacting a laminar flow of the sample with a plurality of solid phase surfaces or surface area supporting a ligand capable of specifically binding the analyte, each surface or surface area having a different ligand density, (b) determining the initial binding rate (dR/dt) of analyte to the ligand at each ligand-supporting surface or surface area, (c) from the determined initial binding rates determining the initial binding rate corresponding to transport-limited interaction at the surfaces or surface areas, and (d) from the initial binding rate determined in step (c) determining the active analyte concentration.Type: ApplicationFiled: June 27, 2012Publication date: May 29, 2014Inventors: Robert Karlsson, Hakan Roos
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Publication number: 20140141529Abstract: A method of determining active concentration of an analyte in a liquid sample, comprises the steps of: (a) contacting a laminar flow of the sample with a solid phase surface or surface area supporting a ligand capable of specifically binding the analyte at at least two different flow rates and under partially or completely mass transport limited conditions; (b) determining the initial binding rate dR/dt of analyte to the ligand at the ligand-supporting surface or surface area, and (c) fitting the initial binding rate data obtained in step (b) to a kinetic interaction model that includes a term for mass transport to obtain the active analyte concentration, wherein steps (a) and (b) are performed at a plurality of different dilutions of the liquid sample, and wherein in step (c) at least several of the plurality of dilutions of the liquid sample are in included in a global fit of initial binding rate data to the kinetic interaction model.Type: ApplicationFiled: June 27, 2012Publication date: May 22, 2014Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Robert Karlsson, Hakan Roos
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Publication number: 20130252846Abstract: A method of screening a plurality of fluid samples for the presence of species capable of specifically binding to a binding partner immobilized on a sensing surface of a sensor is disclosed. The method comprises contacting each sample with the sensing surface and a reference surface, and subjecting the sensing surface responses obtained for all samples to a computational process which comprises fitting al responses to a model equation for the relationship between a response at the sensing surface and the corresponding response at the reference surface. In an iterative process residuals above a pre-determined threshold value are removed, the model equation is adjusted, and all remaining samples are refitted to the adjusted model equation until the model equation at least substantially converges. Residuals above the predetermined threshold value are considered as species specifically binding to the binding partner.Type: ApplicationFiled: November 29, 2011Publication date: September 26, 2013Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Markku Hamalainen, Hakan Roos
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Patent number: 8263415Abstract: A method of determining the total concentration of an analyte in a fluid sample, wherein at least part of the analyte is present as a complex with an analyte-binding species. The methods includes the steps of: a) subjecting the sample to conditions that reduce the binding affinity between analyte and analyte-binding species sufficiently to dissociate substantially any analyte complex and provide substantially all analyte in free form, b) subjecting the sample to conditions that restore the binding affinity between analyte and analyte-binding species, and c) immediately after the binding affinity has been restored, and before any substantial re-complexing of the analyte has taken place, determining the concentration of free analyte in the sample. A method of determining the concentration of complex-bound analyte in a sample is also disclosed.Type: GrantFiled: September 12, 2007Date of Patent: September 11, 2012Assignee: GE Healthcare Bio-Sciences ABInventors: Henrik Berling, Tanja Jarhede, Anita Larsson, Hakan Roos
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Patent number: 8021626Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: April 26, 2010Date of Patent: September 20, 2011Assignee: GE Healthcare Bio-Sciences ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Publication number: 20100260642Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: April 26, 2010Publication date: October 14, 2010Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Magnus Malmqvist, Håkan Roos, Stefan Sjölander, Mattias Tidare, Håkan Sjödin, Ralph Stålberg
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Patent number: 7811515Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: June 30, 2009Date of Patent: October 12, 2010Assignee: GE Healthcare Bio-Sciences ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Publication number: 20100167422Abstract: A method of determining the total concentration of an analyte in a fluid sample, wherein at least part of the analyte is present as a complex with an analyte-binding species. The methods includes the steps of: a) subjecting the sample to conditions that reduce the binding affinity between analyte and analyte-binding species sufficiently to dissociate substantially any analyte complex and provide substantially all analyte in free form, b) subjecting the sample to conditions that restore the binding affinity between analyte and analyte-binding species, and c) immediately after the binding affinity has been restored, and before any substantial re-complexing of the analyte has taken place, determining the concentration of free analyte in the sample. A method of determining the concentration of complex-bound analyte in a sample is also disclosed.Type: ApplicationFiled: September 12, 2007Publication date: July 1, 2010Inventors: Henrik Berling, Tanja Jarhede, Anita Larsson, Hakan Roos
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Patent number: 7736587Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: June 30, 2009Date of Patent: June 15, 2010Assignee: GE Healthcare Bio-Sciences ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Publication number: 20090263285Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: June 30, 2009Publication date: October 22, 2009Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Publication number: 20090263284Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: June 30, 2009Publication date: October 22, 2009Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: MAGNUS MALMQVIST, Hakan Roos, Stefen Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Patent number: 7582487Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: December 6, 2005Date of Patent: September 1, 2009Assignee: GE Healthcare Bio-Sciences ABInventors: Magnus Malmqvist, Håkan Roos, Stefan Sjölander, Mattias Tidare, Håkan Sjödin, Ralph Stålberg
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Publication number: 20060134800Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: December 6, 2005Publication date: June 22, 2006Applicant: Biacore ABInventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Patent number: 7015043Abstract: A method of operating an analytical flow cell device comprising an elongate flow cell having a first end and a second end, at least two ports at the first end and at least one port at the second end, comprises introducing a laminar flow of a first fluid at the first end of the flow cell, and a laminar counter flow of a second fluid at the second end. Each fluid flow is discharged at the first end or the second end, and the position of the interface between the first and second fluids in the longitudinal direction of the flow cell is adjusted by controlling the relative flow rates of the first and second fluids. Also disclosed are a method of analyzing a fluid sample for an analyte, a method of sensitizing a sensing surface, and a method of contacting a sensing surface with a test fluid.Type: GrantFiled: June 26, 2002Date of Patent: March 21, 2006Assignee: Biacore ABInventors: Håkan Roos, Kjell Magnusson, Mattias Tidare
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Publication number: 20050199076Abstract: A method of positioning a laminar flow of a sample fluid on a surface within a flow cell is disclosed. The method comprises providing a laminar flow of a first guiding fluid adjacent to a laminar flow of a second guiding fluid different from the first guiding fluid such that the two fluids flow together over the surface with a detectable interface to each other; detecting the interface between the two different guiding fluids; optionally adjusting the interface laterally to a desired position by adjusting the relative flow rates of the two guiding fluids; and introducing a laminar flow of the sample fluid between the laminar flows of the first and second guiding fluids such that the flow of the sample fluid is sandwiched between the guiding fluids. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.Type: ApplicationFiled: December 6, 2004Publication date: September 15, 2005Applicant: Biacore ABInventors: Mattias Tidare, Hakan Roos
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Publication number: 20030022388Abstract: A method of operating an analytical flow cell device comprising an elongate flow cell having a first end and a second end, at least two ports at the first end and at least one port at the second end, comprises introducing a laminar flow of a first fluid at the first end of the flow cell, and a laminar counter flow of a second fluid at the second end. Each fluid flow is discharged at the first end or the second end, and the position of the interface between the first and second fluids in the longitudinal direction of the flow cell is adjusted by controlling the relative flow rates of the first and second fluids. Also disclosed are a method of analyzing a fluid sample for an analyte, a method of sensitizing a sensing surface, and a method of contacting a sensing surface with a test fluid.Type: ApplicationFiled: June 26, 2002Publication date: January 30, 2003Applicant: Biacore ABInventors: Hakan Roos, Kjell Magnusson, Mattias Tidare
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Publication number: 20010055817Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: ApplicationFiled: January 12, 2001Publication date: December 27, 2001Inventors: Magnus Malmqvist, Hakan Roos, Stefan Sjolander, Mattias Tidare, Hakan Sjodin, Ralph Stalberg
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Patent number: 6200814Abstract: Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell. The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.Type: GrantFiled: January 20, 1998Date of Patent: March 13, 2001Assignee: Biacore ABInventors: Magnus Malmqvist, Håkan Roos, Stefan Sjölander, Mattias Tidare, Håkan Sjödin, Ralph Stålberg