Abstract: Disclosed are glycosides, orthoester glycosides and glycuronamides of fluoxetine and analogs thereof to treat conditions and diseases such as depression.

Abstract: A method and device is described for a quality control device for immunohistochemical testing of surgical biopsies. Immunohistochemistry testing involves the use of antibodies to detect the presence of proteins that have diagnostic or prognostic importance. In this invention, peptides are covalently attached to glass microscope slides. The peptides represent antibody contact sites to the native protein. Namely, the peptide contains the same amino acid sequence as the epitope in the native protein to where the antibody binds. Alternatively, peptides may not necessarily share the exact sequence as found in the native protein but they still bind to the antibody. To use this invention, tissue sections derived from surgical biopsies may be mounted on glass slides bearing the peptides. As the immunohistochemical stain is performed on the tissue section, a similar reaction sequence occurs at the site of the glass slide where the peptide is located.

Abstract: The invention describes quality control devices for assays that measure analytes in cells and tissue samples, and methods of use thereof. In particular, the quality control device comprises a matrix affixed with synthetic controls in different concentrations, or different synthetic controls. The quality control device can be adhered to a microscope slide via an adhesive or chemically attached to a microscope slide and processed simultaneously with a tissue sample.

Abstract: Disclosed are glycoside and orthoester glycoside derivatives of apomorphine and analogs thereof to treat conditions and diseasessuch as erectile dysfunction.

Abstract: Disclosed are conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof, e.g. for imaging cancer cells and tumors in vivo.

Abstract: Disclosed are conjugates comprising cancer cell specific ligands, a sugar and cancer chemotherapeutic agents/boron neutron capture therapy agents, and uses thereof, e.g. for treating or ameliorating hyperproliferative diseases.

Abstract: Disclosed are conjugates comprising an NSAID and a sugar and uses thereof, e.g. for treating or preventing pain, fever and any condition characterized by an inflammatory process.

Abstract: Disclosed are conjugates comprising a central nervous system-active drug linked through an amide bond to a glucuronic acid or glucosamine moiety, and uses thereof, e.g., for treating or ameliorating central nervous system diseases or disorders.

Abstract: Disclosed are glycosides, orthoester glycosides and glycuronamides of fluoxetine and analogs thereof to treat conditions and diseases such as depression.

Abstract: Disclosed are caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins and analogs thereof to treat conditions and diseases such as bacterial infections.

Abstract: The invention describes a method for attaching biological molecules, such as proteins, nucleic acids, and carbohydrates to a glass surface. In particular, a covalent attachment method is described wherein a glass surface is first activated with a water-stable form of an isocyanate, termed a protected isocyanate. The protecting group of the isocyanate moiety is displaced by amines, hydroxyl, or carboxyl groups of biological molecules, leading to covalent attachment to the glass surface.

Abstract: The invention describes quality control devices for assays that measure analytes in cells and tissue samples, and methods of use thereof. In particular, the quality control device comprises a matrix affixed with synthetic controls in different concentrations, or different synthetic controls. The quality control device can be adhered to a microscope slide via an adhesive or chemically attached to a microscope slide and processed simultaneously with a tissue sample.

Abstract: Glycosides and orthoester glyco side derivatives of bisphosphonate compounds useful for treating and/or preventing hypercalcaemia of malignancy, Paget's disease, osteoporosis, metastatic cancer in bone and soft tissue and periodontal disease have markedly enhanced intestinal absorption and enhanced bioavailability.

Abstract: Serum levels of therapeutically useful glucocorticosteroids are substantially increased by oral administration of the corresponding glycoside or orthoester glycoside.

Abstract: This invention relates to novel ketoxime carbonates and a process for the synthesis of ketoxime carbonates generally. Ketoxime carbonates are useful in a variety of applications. They may be used for example as pesticides, pharmaceuticals, weed control agents and dye stuff intermediates.