Abstract: A system for executing manufacturing process or method for producing product is disclosed. The product may be vinyl siding panels. In accordance with the various aspects and embodiments of the invention, the manufacturing process uses a coating (the print) that is very opaque and provides very high weatherability against the UV rays of sunlight. The product has a unique design, which makes it possible to install the product in both horizontal and vertical orientations. The product can be produced in a variety of widths, including wider than normal market sizes. The product includes the features of special design and patterns to replicate the appearance of natural material with the added advantage of permanent and lasting appearance. Further, the product is made using a manufacturing process that includes the ability to use economical recycled materials.

Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents or siRNAs, able to inhibit Complement Component C3 (C3) gene expression. Also disclosed are pharmaceutical compositions that include C3 RNAi agents and methods of use thereof The C3 RNAi agents disclosed herein may be conjugated to targeting ligands, including ligands that comprise N-acetyl-galactosamine, to facilitate the delivery to hepatocyte cells. Delivery of the C3 RNAi agents in vivo provides for inhibition of C3 gene expression. The RNAi agents can be used in methods of treatment of diseases, disorders, or symptoms mediated in part by C3 gene expression, including IgA nephropathy, C3 glomerulopathy, paroxysmal nocturnal hemoglobinuria, and/or other complement-mediated renal diseases.

Abstract: Disclosed herein, inter alia, are methods of treating renal disease (e.g., chronic kidney disease or end stage renal disease).