Publication number: 20060030599
Abstract: Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula R1-L-NHSO2R2??I in which R1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C) chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)
Type:
Application
Filed:
May 29, 2003
Publication date:
February 9, 2006
Inventors:
Macklin Arnold, Stephen Baker, Thomas Bleisch, Buddy Cantrell, Ana Escribano, Ken Matsumoto, Tracey Mckennon, Paul Ornstein, Richard Simon, Edward Smith, Hamideh Zarrinmayeh, Dennis Zimmerman
