Abstract: A modified polymer as result of a bulk functionalization of polyamide 46 (PA 46) is presented, as well as methods for synthesizing the modified polymer. This functionalization of PA 46 is performed to provide a homogenous semi-permeable polyamide 46 capable of different charges and different porosities with particles of nanoscale size in order to replace or improve other polyamide fibers used in the textile industry, filtering processes, selective sorption, controlled release devices, phase transfer catalysts, chromatography media, biocompatible capsules, artificial skins, organs, bone void repair as well as in cell bioreactors and incubators, dental implements, medical devices, clothing, detectors, perfusion devices, in regenerative medicine, and fuel cells.