Abstract: An isolated monoclonal antibody or an antigen-binding fragment thereof is disclosed. The antibody or the antigen-binding fragment is characterized by: (a) having a specific binding affinity to epithelial cell adhesion molecule (EpCAM) comprising the amino acid sequence of SEQ ID NO: 1; (b) having a specific binding affinity to cancer cells expressing EpCAM said cancer cells being selected from the group consisting of oral cancer cells, nasopharyngeal cancer cells (NPC), colorectal cancer cells, and ovarian cancer cells; and (c) having no binding affinity to human umbilical vein endothelial cell (HUVEC) and normal nasal mucosal epithelia (NNM). Also disclosed is an isolated monoclonal antibody or an antigen-binding fragment thereof that has a specific binding affinity to an epitope within the sequence of KPEGALQNNDGLYDPDCDE (SEQ ID NO: 63) located within the EGF-like domain II of epithelial cell adhesion molecule (EpCAM). Methods of using the same are also disclosed.

Abstract: A semiconductor device is provided and includes a substrate of a first conductivity type, a deep well of a second conductivity type, and a first high-side device. The deep well is formed on the substrate. The first high-side device is disposed within the deep well and includes an insulation layer of the second conductivity type, a well of the first conductivity type, first and second regions of the second conductivity type, and a first poly-silicon material. The insulation layer is formed on the substrate. The well is formed within the deep well. The first and second regions are formed within the well. The first poly-silicon material is disposed between the first region and the second region and on the deep well.

Abstract: The disclosure relates to a touch panel. The touch panel includes a conductive layer including a number of first electrodes, a number of second electrodes and a number of conductive wires. Each first electrode and second electrode is electrically connected to one conductive wire. Each first electrode includes at least one first bus bar extending along a Y direction, and each second electrode includes at least one second bus bar extending along the Y direction. The first bus bars and the second bus bars are alternately arranged along a X direction. The touch panel further includes a first offset electrode adjacent to an edge of the conductive layer, spaced from the outermost first bus bar, and electrically connected to one of the second bus bars that is adjacent to the outermost first bus bar. The first offset electrode includes a third bus bar extending along the Y direction.

Abstract: An image acquiring method for acquiring an image using a measurement apparatus including an image acquiring means which acquires an image of a surface of a target to be measured in the unit of predetermined size pixels and a moving means capable of moving the target to be measured, the image acquiring method includes: acquiring an image of a first region from the surface of the target to be measured through the image acquiring means; acquiring an image of a second region, which is different from the first region, by moving the target to be measured, through the moving means; acquiring a differential image by subtracting, from either the image of the first region or the image of the second region, the other image; and overlapping the differential image multiple times.

Abstract: Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell surface antigen (e.g., cancer cell surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be targeted by the antibodies include carcinomas, such as those in lung, kidney, liver, stomach, breast, and brain, etc.

Abstract: A tank for safely storing a fuel in a high-pressure gaseous state, and a method for manufacturing the tank are provided. The fuel gas storage tank includes a composite material that forms a tank shell and a liner disposed under the composite material. In addition, the liner has a structure in which a metal coil is integrally formed within the liner.

Abstract: A method of manufacture of an integrated circuit packaging system includes: providing a substrate; attaching an integrated circuit to the substrate; molding an encapsulation directly on the integrated circuit and the substrate; forming a trench in the encapsulation having a trench bottom surface and surrounding the integrated circuit; and mounting a heatsink having a heatsink rim over the integrated circuit with the heatsink rim within the trench and the heatsink electrically isolated from the substrate.

Abstract: A memory controller is provided. The memory controller includes a memory interface and an encoding module. The memory interface is configured to couple to a memory chip. The encoding module is coupled to the memory interface and includes a shared memory and a parity generation module. The parity generation module is coupled to the shared memory. The parity generation module reads at least one basic vector from the shared memory, determines a dimension of the at least one basic vector, generates a generation matrix according to the at least one basic vector, converts a raw data into a codeword through the generation matrix, and stores the codeword into the memory chip through the memory interface.

Abstract: An antibody that binds C terminal region of angiopoietin like 4 protein its use and methods of treating cancer with the same.

Abstract: An integrated circuit packaging system, and method of manufacture therefor, includes: a substrate; a mold cap formed on the substrate; fiducial mark inscribed in the mold cap; a thermal interface material applied over the substrate and referenced by the fiducial mark; and a heat spreader, mounted on the thermal interface material, precisely positioned by a position notch aligned relative to the fiducial mark.

Abstract: A peptide targeted conjugate is disclosed. The conjugate comprises: (a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 1, 2 and 3; and (b) a component, to which the targeting peptide is conjugated, the component being selected from the group consisting of a drug delivery vehicle, an anti-cancer drug, a micelle, a nanoparticle, liposomes, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a cell, an imaging agent, and a labeling agent. The conjugate may further comprise an anti-cancer agent encapsulated within the drug delivery vehicle. Compositions and methods of treating cancer are also disclosed.

Abstract: A conjugate is disclosed. The conjugate comprises (a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 1-8; and (b) a component conjugated to the targeting peptide, the component being selected from the group consisting of a drug delivery vehicle, an anti-cancer drug, a micelle, a nanoparticle, a liposome, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a cell, an imaging agent, and a labeling agent. Methods of treating lung cancer and detecting lung cancer cells are also disclosed.

Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.

Abstract: A casing of an electronic device including a casing body and a sensing assembly is provided. The casing body includes a button portion. The sensing assembly includes a first conductive line and two first contacts. The first conductive line is disposed on an inner surface of the casing body, and the first conductive line forms a strain sensing pattern on the button portion. The first contacts are disposed on the inner surface of the casing body, and connected to two ends of the first conductive line, respectively. The strain sensing pattern is adapted to result a resistance variation accompanied with a deformation of the button portion when the button portion is deformed, so as to generate an electrical signal.

Abstract: A spring mattress structure comprises a mattress body with a top bed surface and a bottom bed surface which consists of a plurality of shaft levers separated by a regular spacing between any two adjacent shaft levers and prepared for placement of a plurality of springs; each of the springs allows the bottom's both ends to be placed on surfaces of two adjacent shaft levers and develops a hollow space which correspond to a spacing developed by the two adjacent shaft levers; the bottom of each spring is fixed on one of the shaft levers with a spring-loaded locating piece so that the spring is securely connected to the shaft lever.

Abstract: The present invention provides a method of peptide histochemical diagnosis to detect the peptide binding protein in the cancer tissue. This peptide binding specifically to tumor cells is linked to the dextran coated iron oxide nanoparticle. The peptide linked dextran coated iron oxide nanoparticle can be used to bind to the formalin-fixed and paraffin-embedded tumor surgical specimens, and the method of present invention can be used to evaluate the efficacy of peptide-targeted chemotherapy for treatment of cancer patients.

Abstract: An integrated circuit packaging system, and method of manufacture therefor, includes: a substrate; a mold cap formed on the substrate; fiducial mark inscribed in the mold cap; a thermal interface material applied over the substrate and referenced by the fiducial mark; and a heat spreader, mounted on the thermal interface material, precisely positioned by a position notch aligned relative to the fiducial mark.

Abstract: A spring mattress structure comprises a mattress body with a top bed surface and a bottom bed surface developed by a plurality of shaft levers which are regularly arranged and separated by a spacing: each of the shaft levers on which a plurality of springs are installed allows each spring's two bottom ends to be positioned at two adjacent springs; each of the springs has a hollow space corresponding to the spacing developed by two adjacent shaft levers and makes its bottom fixed on a shaft lever with a spring-loaded locating piece; the spring-loaded locating piece comprises a locating part on which a shaft lever is fixed; the locating part has elastic fasteners extending from both sides and used to clamp spring coils of springs so that the springs are stably connected to shaft levers.

Abstract: A touch panel includes a substrate with a surface and a patterned transparent conductive layer located on the surface of the substrate. The patterned transparent conductive layer includes a plurality of pairs of sensor electrodes arranged adjacent to each other in an X direction. Each of the plurality of pairs of sensor electrodes includes a first electrode and a second electrode opposite to the first electrode. A pattern of the first electrode and the second electrode is designed as a right triangle shape or a right angled trapezoid shape. One side of the right triangle shape or the right angled trapezoid shape parallel to a Y direction extends in a plurality of zigzag shapes, wherein the X direction is perpendicular to the Y direction. The present invention also relates to a liquid crystal display device including the touch panel.

Abstract: A purified monoclonal antibody, or an. antigen-binding portion thereof, which specifically binds to human clathrin heavy chain (CHC) is disclosed. The antibody, or antigen-binding portion, thereof, exhibits at least one, two, three, four, five, six, seven, or all eight of the following properties: (a) specifically binds to pancreatic adenocarcinoma cells; (b) binding to the cell surface and cytosol of cancer cells and tumor blood vessels; (c) internalized by CHC-expressing cells; (d) inhibiting tumor growth, invasion ability, migration, and angiogenesis; (e) inducing apoptosis in cancer cells and human umbilical vein endothelial cells; (f) inhibiting tumor growth and tumor blood vessels in pancreatic cancer in vivo; (g) suppressing epidermal growth factor, transferrin, and VEGF internalizations by cancer cells; and (h) suppressing hypoxia-inducible factor-1? expression and vascular endothelial growth factor secretion.