Patents by Inventor Han Kiat Ho

Han Kiat Ho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzylidene-indolinone compounds and their medical use
    Patent number: 8877946
    Abstract: Compounds of general formula I: wherein R1a, R1b, R2, R3a, R3b and X are as defined herein are tyrosine kinase inhibitors and are useful for the treatment of various diseases and conditions, for example cancer.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: November 4, 2014
    Assignee: National University of Singapore
    Inventors: Mei Lin Go, Han Kiat Ho, Xiao Chen
  • BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE
    Publication number: 20130035364
    Abstract: Compounds of general formula I: wherein R1a, R1b, R2, R3a, R3b and X are as defined herein are tyrosine kinase inhibitors and are useful for the treatment of various diseases and conditions, for example cancer.
    Type: Application
    Filed: August 1, 2012
    Publication date: February 7, 2013
    Inventors: Mei Lin GO, Han Kiat HO, Xiao CHEN
  • NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES
    Publication number: 20110269812
    Abstract: The present invention relates generally to organic chemistry, biochemistry, pharmacology and medicine. More particularly, it relates to 3-benzylidene-indolin-2-one derivatives and their physiologically acceptable salts and prodrugs which modulate the activity of protein kinases (“PKs”), especially protein tyrosine kinase, and, therefore, are expected to exhibit a salutary effect against disorders related to abnormal PK activity. The present invention is further directed to methods of using of these compounds, alone or in combination with other therapeutic agents, for the alleviation, prevention and/or treatment of protein kinase-mediated diseases and disorders, such as cancer.
    Type: Application
    Filed: October 14, 2009
    Publication date: November 3, 2011
    Applicants: Agency for Science, Technology and Research, National University of Singapore
    Inventors: Mei Lin Go, Han Kiat Ho, Wei Zhang